Tag

Hearing Restoration

All articles tagged with #hearing restoration

health1 month ago•67 min saved

Gene therapy brings near-normal hearing to most with inherited deafness in largest trial

In the largest trial to date, a gene therapy delivering functional copies of the OTOF gene to the inner ear improved hearing in about 90% of participants (38 of 42) with congenital deafness caused by OTOF mutations, across eight sites in China. Improvements began within weeks and persisted for up to two years in many cases; some participants achieved normal conversational hearing, while a few showed no benefit. The therapy had no serious side effects, though some mild vertigo or inner-ear inflammation occurred, and younger patients tended to improve more. If further trials confirm long-term safety and broader applicability, the approach could offer a one‑and‑done alternative or complement to cochlear implants, with next steps including longer follow-up and dosing studies.

via Live Science|

#clinical-trial #congenital-deafness #gene-therapy

science1 month ago•25 min saved

Durable hearing gains from multicenter AAV1-hOTOF gene therapy for OTOF-related deafness

In a multicenter, single-arm trial across eight centers, 42 participants with autosomal recessive OTOF-related congenital deafness received AAV1-hOTOF at three doses. No dose-limiting toxicities were observed, and 90% of treated ears achieved hearing recovery with progressive, durable improvements in ABR/ASSR thresholds and speech perception up to 2.5 years. Younger participants showed greater gains, and baseline DPOAE strength and certain OTOF variants predicted better outcomes, supporting broad efficacy and safety of the therapy over up to 2.5 years.

via Nature|

#aav1 #congenital-deafness #gene-therapy

health10 months ago•4 min saved

Breakthrough Gene Therapy Restores Hearing in Teens and Adults

A new gene therapy using a modified virus has successfully restored hearing in teens and adults with OTOF-related congenital deafness, showing promising results especially in children aged 5-8, with significant safety and efficacy observed over a 12-month period.

via Live Science|

#clinical-trial #deafness #gene-therapy

health10 months ago•2 min saved

Single-Injection Gene Therapy Restores Hearing in Deaf Adults

A new gene therapy using a synthetic virus has successfully restored hearing in children, teenagers, and adults with a genetic form of deafness caused by OTOF mutations, showing significant improvements within six months and with no serious side effects, offering hope for broader treatments in the future.

via IFLScience|

#clinical-trial #deafness #gene-therapy

health10 months ago•4 min saved

Gene Therapy Reverses Hearing Loss in Adults and Children

A groundbreaking clinical trial demonstrates that gene therapy using a modified virus can successfully restore hearing in children and young adults with OTOF-related deafness, showing promising safety and efficacy, especially in children aged five to eight, marking a significant advancement in treating genetic hearing loss.

via ScienceAlert|

#clinical-trial #gene-therapy #genetic-deafness

health2 years ago•3 min saved

"Groundbreaking Gene Therapy Restores Hearing in Deaf Children"

A gene therapy trial has successfully restored hearing in both ears for five children born deaf due to genetic mutations. Conducted by doctors at Fudan University in Shanghai and co-led by Massachusetts Eye and Ear, the therapy uses an inactive virus to deliver working copies of the Otof gene to the inner ear. The children, aged between one and 11, showed significant improvements in hearing and speech recognition within weeks. The trial's success raises hopes for broader applications of gene therapy in treating various forms of deafness.

via The Guardian|

#deafness #gene-therapy #health

health2 years ago•3 min saved

"Gene Therapy Restores Hearing in Children with Hereditary Deafness: A Breakthrough Treatment"

A new study has demonstrated the effectiveness of gene therapy in restoring hearing function for children with hereditary deafness caused by mutations of the OTOF gene. In a trial of six children, the gene therapy was found to be an effective treatment, resulting in dramatic improvements in speech perception and the ability to conduct normal conversation. This research represents the first human clinical trial to administer gene therapy for this condition, with promising results that could potentially benefit other forms of genetic hearing loss.

via Medical Xpress|

#children #gene-therapy #health

science-and-technology2 years ago•4 min saved

"Surprising Findings Unleash Breakthroughs in Hearing Restoration"

Researchers have discovered a new method to deliver gene therapy through cerebrospinal fluid to restore hearing in deaf mice by repairing inner ear hair cells. By utilizing the brain's natural fluid flow and a little-understood passage called the cochlear aqueduct, the scientists successfully restored hearing in adult deaf mice. This breakthrough may pave the way for using gene therapy to restore hearing in humans with genetic-mediated hearing loss.

via SciTechDaily|

#cerebrospinal-fluid #deafness #gene-therapy

health2 years ago•3 min saved

Revolutionary Gene Therapy Opens New Path for Restoring Hearing

Researchers have discovered a new method to deliver gene therapy into the inner ear by utilizing the natural flow of cerebrospinal fluid through a little understood passage called the cochlear aqueduct. By injecting an adeno-associated virus into the cerebrospinal fluid, the researchers were able to deliver a gene therapy that repaired inner ear hair cells and restored hearing in adult deaf mice. This breakthrough could pave the way for future gene therapies to restore hearing in humans with genetic-mediated hearing loss.

via Medical Xpress|

#cerebrospinal-fluid #deaf-mice #gene-therapy