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Mrna Vaccines

All articles tagged with #mrna vaccines

health1 month ago•14 min saved

Personalized mRNA Cancer Vaccines Show Promise Amid Turbulence

A small Memorial Sloan Kettering study finds a patient-specific mRNA vaccine for pancreatic cancer can provoke strong immune responses and deliver long-term survivors, despite a turbulent year of funding and public skepticism around mRNA. Eight of 16 patients had a meaningful immune response and seven are alive six years after the trial; larger multisite trials and industry backing are advancing the approach, which also includes non-personalized, off-the-shelf vaccines aiming to trigger broader anti-tumor immunity.

via WRAL|

#cancer-vaccines #health #immunotherapy

science1 month ago•30 min saved

mRNA vaccines prime CD8+ T cells through two dendritic routes and cross-dressed MHC-I

Nature reports that mRNA–LNP vaccines prime CD8+ T cells not through the classic cDC1 cross-presentation, but via redundant input from both cDC1 and cDC2 dendritic cells; a substantial portion of priming comes from cross-dressing—peptide–MHC-I complexes transferred from non-hematopoietic cells in a type I interferon–dependent process—broadening T-cell activation to antigens not encoded by the vaccine and supporting anti-tumor immunity and memory.

via Nature|

#cd8-t-cells #cross-dressing #cross-presentation

health2 months ago•12 min saved

Misinformation could slow the next wave of cancer vaccines

Researchers are advancing personalized mRNA cancer vaccines that may transform cancer care, but the spread of misinformation—notably the turbo cancer myth tying COVID-19 vaccines to aggressive cancers—could erode public trust and hinder adoption; proactive, transparent science communication and clinician conversations are essential to realizing these vaccines’ potential.

via The Conversation|

#cancer-vaccines #health #health-communication

health2 months ago•6 min saved

ACIP backs away from withdrawing COVID-19 mRNA vaccine guidance

A federal vaccine advisory panel has dropped plans to withdraw the COVID-19 mRNA vaccine recommendation, even after some members floated removing the shots amid safety concerns. Current guidance remains in place, with upcoming discussions on vaccine injuries and long COVID, as uptake of the updated shot stays low and political concerns loom over vaccine policy.

via The Washington Post|

#acip #covid-19 #fda

health3 months ago•1 min saved

FDA Signals Review for Moderna's Next-Gen Flu Vaccine

The FDA has reversed its earlier stance and agreed to review Moderna’s updated mRNA flu vaccine, with plans for full approval in adults 50–64 and accelerated approval for those 65 and older, plus a post-marketing study in older adults. A decision is expected by August 5, and Moderna shares rose on the news.

via NBC News|

#approval-timeline #fda #health

business4 months ago•3 min saved

Sanofi shelves mRNA seasonal flu effort, pivots to proven vaccines

Sanofi has deprioritized its phase 1 mRNA seasonal flu program, scrapping the effort as part of a broader strategic shift, while continuing to pursue an mRNA vaccine for an H5 pandemic and focusing on established influenza vaccines (Fluzone High-Dose, Flublok). The influenza/COVID vaccine franchise generated €2.3 billion last year, a 6% decline from 2024 amid lower US immunization rates, and the company underscored a multi‑platform vaccine strategy, including the Dynavax acquisition, as its growth path.

via Fierce Biotech|

#business #influenza-vaccines #mrna-vaccines

health5 months ago•7 min saved

Stanford Researchers Explain mRNA COVID Vaccine-Induced Heart Inflammation

Stanford researchers have identified that rare cases of heart inflammation post-mRNA COVID-19 vaccination are driven by immune responses involving cytokines CXCL10 and IFN-gamma, and found that the soy-derived compound genistein may help reduce this inflammation, offering insights into safer vaccine strategies.

via ScienceDaily|

#cytokines #genistein #health

health5 months ago•8 min saved

Stanford Researchers Uncover Cause of Myocarditis Post-COVID mRNA Vaccines

Stanford researchers have uncovered a biological mechanism explaining why rare cases of myocarditis occur after mRNA COVID-19 vaccination, identifying two cytokines, CXCL10 and IFN-gamma, as key drivers of heart inflammation, and suggesting that cytokine inhibitors or dietary supplements like genistein could potentially reduce this risk.

via SciTechDaily|

#covid-19 #cytokines #health

health5 months ago•1 min saved

Stanford Study Links mRNA COVID Vaccines to Myocarditis

A Stanford Medicine study indicates that mRNA COVID-19 vaccines can cause myocarditis, especially in young men and adolescents, with a very low incidence rate, but most cases recover fully and the benefits of vaccination outweigh the risks.

via National News Desk|

#covid-19 #health #mrna-vaccines

health6 months ago•5 min saved

COVID-19 Vaccines Show Promise in Extending Cancer Patient Survival

A recent study suggests that Covid mRNA vaccines may boost the immune response in cancer patients, significantly increasing their median survival time and potentially revolutionizing cancer treatment by repurposing existing vaccines to enhance immune system activation, though further research is needed to confirm causation.

via The Guardian|

#cancer-treatment #covid-vaccines #health

health6 months ago•5 min saved

Hidden COVID Vaccine Side Effect Revealed

A study suggests that mRNA COVID vaccines like Pfizer and Moderna may enhance survival rates in cancer patients undergoing immunotherapy, potentially 'priming' the immune system to fight cancer more effectively, though more research is needed; the vaccines remain primarily important for preventing COVID-19 complications.

via AOL.com|

#cancer #covid-vaccine #health

health6 months ago•5 min saved

Hidden COVID Vaccine Side Effect Revealed

A study suggests that mRNA COVID-19 vaccines like Pfizer and Moderna may enhance survival rates in cancer patients undergoing immunotherapy, potentially 'priming' the immune system to fight cancer more effectively, though more research is needed; the vaccine's primary benefit remains COVID-19 prevention.

via Yahoo|

#cancer-survival #covid-vaccine #health

health7 months ago•5 min saved

COVID-19 mRNA vaccines enhance cancer treatment and survival

New research suggests that COVID-19 mRNA vaccines may boost survival rates in patients with advanced lung and skin cancers when administered within 100 days of starting immunotherapy, potentially paving the way for a universal cancer vaccine. The findings, based on patient data and mouse experiments, are preliminary but promising, prompting plans for further clinical trials.

via ScienceDaily|

#cancer-survival #covid-19 #health

health7 months ago•6 min saved

mRNA COVID-19 vaccines show promise in cancer treatment and immunotherapy

Recent studies suggest that COVID-19 mRNA vaccines may also help the immune system recognize and attack cancer tumors, potentially improving survival rates and transforming cancer treatment, though further clinical trials are needed to confirm these findings.

via Al Jazeera|

#cancer #covid-19 #health

health7 months ago•0 min saved

mRNA COVID vaccines enhance cancer treatment outcomes and survival

A study by the University of Texas MD Anderson and the University of Florida found that mRNA COVID-19 vaccines not only protect against the virus but also nearly double the median survival time of cancer patients by boosting the immune system.

via The Washington Post|

#cancer #covid-19-vaccines #health