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Mrna Vaccines

All articles tagged with #mrna vaccines

science5 days ago•45 min saved

Cancer vaccines edge toward breakthrough, but misinformation could slow adoption

An mRNA cancer vaccine has achieved a late-stage success—Moderna and Merck's personalized vaccine intismeran autogene reduced melanoma recurrence when paired with Keytruda—pointing to a new frontier in cancer treatment and prevention, but persistent misinformation about mRNA technology, including the 'turbo cancer' narrative, threatens to erode public trust and slow adoption; experts say proactive, transparent communication, clinician training, and public health messaging are essential to translate scientific progress into real-world benefits.

via Yahoo News Singapore|

#cancer-vaccine #misinformation #mrna-vaccines

health5 days ago•204 min saved

Breakthrough Cancer Vaccine Gains Ground, but Misinformation Could Stall It

A personalized mRNA cancer vaccine from Moderna and Merck reduced melanoma recurrence when combined with Keytruda in a late-stage trial, signaling a potential new era in cancer prevention and treatment, but wide-spread misinformation about mRNA technology—including the ‘turbo cancer’ narrative—could undermine public trust and slow adoption of these advances.

via CNN|

#cancer-vaccines #health #immunotherapy

health23 days ago•20 min saved

FDA approves Moderna's mRNA flu shot for adults 50+, signaling a new vaccine era

The FDA has approved Moderna’s first mRNA-based flu vaccine for adults 50 and over, after an advisory panel’s unanimous vote, with the shot expected to be sold at retailers in coming weeks; the decision comes amid controversy and skepticism from RFK Jr. and expands flu-immunization options.

via The Washington Post|

#fda #flu #health

health1 month ago•87 min saved

States Push Vaccine Rollbacks, but Most Proposals Fell Short

Lawmakers in 34 states introduced more than 200 bills to roll back vaccination rules this year, part of a broader 400+ vaccine-related proposals; only nine became law. Bills spanned five categories—weakening requirements, protecting the unvaccinated, promoting vaccine-dangers claims, altering vaccination systems, and targeting mRNA/Covid vaccines—and public health experts warned such measures could erode vaccine confidence and uptake even if they didn’t pass, as momentum stalled after national attention and White House pressure. Advocates promise to push similar proposals again next session.

via The New York Times|

#health #mrna-vaccines #public-health

health1 month ago•2 min saved

Lancet Review Confirms mRNA Vaccines: Safe, Effective, and Broadly Beneficial

A Lancet review of billions of doses finds mRNA vaccines are safe, highly effective at preventing disease spread, and promising for future uses like cancer treatment; they do not alter human DNA, are safe for children and pregnant people, and boosters extend protection, though rare side effects can occur—emphasizing transparent safety communication to counter misinformation.

via Futurism|

#boosters #health #lancet-study

health2 months ago•4 min saved

FDA panel backs first mRNA flu shot for older adults

An FDA advisory panel unanimously recommended approving Moderna’s mFlusiva, the first influenza vaccine made with mRNA technology, for adults ages 50–64 and 65+ pending final FDA clearance by early August. The shot could enable faster manufacturing and better matching to circulating strains. In trials, it reduced flu cases by about 27% in people 50+ versus a standard vaccine and produced a strong immune response in 65+ compared with a high-dose vaccine, with mostly mild, temporary reactions. If approved, Moderna will run a large follow-up study (about 400,000 people 65+) over two seasons to gather more safety and efficacy data, including in frail or immunocompromised individuals.

via ScienceAlert|

#fda-advisory-committee #health #influenza

health2 months ago•4 min saved

FDA panel endorses Moderna’s next-gen mRNA flu shot for older adults

An FDA advisory panel unanimously recommended Moderna’s mRNA flu vaccine (mFlusiva) for adults 50 and older, approving it for two age groups (50–64 and 65+), with a requirement for an additional post‑market trial in the older cohort. In trials, the shot was about 27% more effective than standard flu vaccines. If FDA and then CDC sign off, it could become the first mRNA influenza vaccine, and its flexible, quickly updated design could help match circulating strains, though final timelines and access this fall remain uncertain amid regulatory and political considerations.

via NBC News|

#fda-approval #health #influenza-vaccine

health4 months ago•14 min saved

Personalized mRNA Cancer Vaccines Show Promise Amid Turbulence

A small Memorial Sloan Kettering study finds a patient-specific mRNA vaccine for pancreatic cancer can provoke strong immune responses and deliver long-term survivors, despite a turbulent year of funding and public skepticism around mRNA. Eight of 16 patients had a meaningful immune response and seven are alive six years after the trial; larger multisite trials and industry backing are advancing the approach, which also includes non-personalized, off-the-shelf vaccines aiming to trigger broader anti-tumor immunity.

via WRAL|

#cancer-vaccines #health #immunotherapy

science4 months ago•30 min saved

mRNA vaccines prime CD8+ T cells through two dendritic routes and cross-dressed MHC-I

Nature reports that mRNA–LNP vaccines prime CD8+ T cells not through the classic cDC1 cross-presentation, but via redundant input from both cDC1 and cDC2 dendritic cells; a substantial portion of priming comes from cross-dressing—peptide–MHC-I complexes transferred from non-hematopoietic cells in a type I interferon–dependent process—broadening T-cell activation to antigens not encoded by the vaccine and supporting anti-tumor immunity and memory.

via Nature|

#cd8-t-cells #cross-dressing #cross-presentation

health5 months ago•12 min saved

Misinformation could slow the next wave of cancer vaccines

Researchers are advancing personalized mRNA cancer vaccines that may transform cancer care, but the spread of misinformation—notably the turbo cancer myth tying COVID-19 vaccines to aggressive cancers—could erode public trust and hinder adoption; proactive, transparent science communication and clinician conversations are essential to realizing these vaccines’ potential.

via The Conversation|

#cancer-vaccines #health #health-communication

health5 months ago•6 min saved

ACIP backs away from withdrawing COVID-19 mRNA vaccine guidance

A federal vaccine advisory panel has dropped plans to withdraw the COVID-19 mRNA vaccine recommendation, even after some members floated removing the shots amid safety concerns. Current guidance remains in place, with upcoming discussions on vaccine injuries and long COVID, as uptake of the updated shot stays low and political concerns loom over vaccine policy.

via The Washington Post|

#acip #covid-19 #fda

health6 months ago•1 min saved

FDA Signals Review for Moderna's Next-Gen Flu Vaccine

The FDA has reversed its earlier stance and agreed to review Moderna’s updated mRNA flu vaccine, with plans for full approval in adults 50–64 and accelerated approval for those 65 and older, plus a post-marketing study in older adults. A decision is expected by August 5, and Moderna shares rose on the news.

via NBC News|

#approval-timeline #fda #health

business7 months ago•3 min saved

Sanofi shelves mRNA seasonal flu effort, pivots to proven vaccines

Sanofi has deprioritized its phase 1 mRNA seasonal flu program, scrapping the effort as part of a broader strategic shift, while continuing to pursue an mRNA vaccine for an H5 pandemic and focusing on established influenza vaccines (Fluzone High-Dose, Flublok). The influenza/COVID vaccine franchise generated €2.3 billion last year, a 6% decline from 2024 amid lower US immunization rates, and the company underscored a multi‑platform vaccine strategy, including the Dynavax acquisition, as its growth path.

via Fierce Biotech|

#business #influenza-vaccines #mrna-vaccines

health8 months ago•7 min saved

Stanford Researchers Explain mRNA COVID Vaccine-Induced Heart Inflammation

Stanford researchers have identified that rare cases of heart inflammation post-mRNA COVID-19 vaccination are driven by immune responses involving cytokines CXCL10 and IFN-gamma, and found that the soy-derived compound genistein may help reduce this inflammation, offering insights into safer vaccine strategies.

via ScienceDaily|

#cytokines #genistein #health

health8 months ago•8 min saved

Stanford Researchers Uncover Cause of Myocarditis Post-COVID mRNA Vaccines

Stanford researchers have uncovered a biological mechanism explaining why rare cases of myocarditis occur after mRNA COVID-19 vaccination, identifying two cytokines, CXCL10 and IFN-gamma, as key drivers of heart inflammation, and suggesting that cytokine inhibitors or dietary supplements like genistein could potentially reduce this risk.

via SciTechDaily|

#covid-19 #cytokines #health