All articles tagged with #muscle metabolism
A Japanese study found that pterostilbene, a natural polyphenol in blueberries and grapes, reduces fat buildup and boosts fatty acid oxidation in cultured mouse muscle cells by preserving the fat-regulating protein PPAR-delta, offering a framework for foods or supplements that target muscle fat metabolism; however, the findings are in cell models and human relevance remains unproven, necessitating further research.
An experimental oral β2 agonist pill activates metabolism in skeletal muscle to lower blood sugar and increase fat burning without reducing appetite or causing muscle loss, addressing downsides seen with GLP-1 drugs like Ozempic. Early Phase I results show good tolerability in healthy volunteers and people with type 2 diabetes, with Phase II trials planned to test efficacy and potential use alone or with existing therapies.
A new study from Harvard Medical School suggests that the immune system plays a role in the beneficial effects of exercise. The study, conducted in mice, found that muscle inflammation caused by exertion mobilizes T cells, or Tregs, which help improve muscle metabolism and overall exercise endurance. Tregs, known for countering inflammation in autoimmune diseases, are now recognized as key players in the immune response during exercise. The findings provide insights into the cellular mechanisms behind exercise's anti-inflammatory effects and highlight the potential of exercise to boost the body's immune responses and reduce inflammation.