All articles tagged with #nature metabolism
A 2024 study in Nature Metabolism reveals that seven days of water-only fasting causes coordinated biological changes across multiple organs, with significant molecular shifts emerging only after approximately three days of calorie restriction.
A UF Health AI-assisted study published in Nature Metabolism analyzed records from 2012–2024 (over 50,000 patients with dementia or MCI). It found that about 8% used glucosamine and, among those with MCI, users were 25% more likely to progress to dementia, while among patients with dementia, use was linked to a 25% higher risk of death. The authors caution this is associative, not causal, and call for controlled trials. Glucosamine can cross the blood–brain barrier and may influence protein sugar-tagging in Alzheimer’s brains. If you have dementia or MCI and take glucosamine, discuss alternatives with a clinician; healthy adults face no immediate alarm.
New research links glucosamine, a common osteoarthritis supplement, to faster dementia progression. In mice, glucosamine increased brain glycan production and worsened memory; in humans, ADRD patients who used glucosamine had about a 25% higher mortality risk over about 5 years, while those with milder cognitive impairment showed no mortality increase. Researchers caution that findings are not proof of causation and call for more studies before changing supplement guidance.