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Otulin

All articles tagged with #otulin

science2 months ago•4 min saved

OTULIN: A Master Switch for Tau Points to a New Alzheimer’s Target

Researchers show the enzyme OTULIN acts as a master regulator of tau production in neurons: blocking OTULIN reduced tau levels and removing its gene even halted tau synthesis, while RNA analysis revealed widespread changes in gene activity, notably in inflammatory pathways; the findings open a potential new route to slow brain aging and Alzheimer's, but safety concerns remain since OTULIN and tau have essential functions and much more research is needed.

via ScienceAlert|

#alzheimers-disease #inflammation #neurodegeneration

science2 months ago•6 min saved

OTULIN Emerges as Master Regulator to Rewire Brain Aging

A study identifies OTULIN as a high-level regulator in neurons that controls gene expression and RNA metabolism, shaping tau biology in brain aging and Alzheimer's disease. Partial inhibition of OTULIN reduced pathogenic tau, while CRISPR deletion nearly abolished tau by silencing MAPT mRNA, but also caused widespread transcriptome changes. The work suggests therapies could recalibrate neuronal regulatory networks to counter aging and neurodegeneration, though complete loss of OTULIN would be harmful and requires precise tuning.

via The Debrief|

#alzheimers-disease #brain-aging #gene-expression

science2 months ago•7 min saved

OTULIN Regulates Tau in Neurons, Opening Alzheimer’s Therapy Avenues

Researchers at the University of New Mexico found that OTULIN, an enzyme known for immune regulation, also controls tau production in neurons. By inhibiting OTULIN with a small molecule or knocking out the OTULIN gene, they stopped new tau formation and cleared existing tau in human neuron models, suggesting a novel target for treating Alzheimer’s disease and related tauopathies. The findings also linked OTULIN to RNA metabolism and inflammatory pathways, and researchers note the need to study effects across different brain cell types before pursuing therapies.

via SciTechDaily|

#alzheimers-disease #brain-aging #neurodegenerative-diseases