Tag

Neurodegenerative Diseases

All articles tagged with #neurodegenerative diseases

science1 month ago•5 min saved

Ketogenic Diet Could Shield the Brain From Neurodegenerative Diseases, Review Finds

A new review finds the ketogenic (keto) diet could offer neuroprotection against diseases like Alzheimer's, Parkinson's, and Huntington's by altering energy metabolism and increasing ketone use, which may reduce inflammation, boost autophagy, and improve gut-brain health; though most supporting studies are in animals, long-term safety, practicality, and clinical efficacy in people remain uncertain, and more trials are needed.

via ScienceAlert|

#brain-health #ketogenic-diet #ketosis

science2 months ago•5 min saved

Scientists Aim to Clean Up RNA Pollution to Halt Neurodegeneration

A UC San Diego–led collaboration with the Salk Institute and Sanford Burnham Prebys has received a four-year, $13 million CIRM grant to study RNA pollution as a root cause of age-related neurodegeneration. The team will use a transdifferentiation approach to convert patient skin cells into age-retaining induced neurons (iNs), map RNA pollution across more than 200 cell lines and patient biofluids, and explore how mitochondrial energy production contributes to RNA pollution. They will employ robotics to screen thousands of potential therapies (including FDA-approved drugs and targeted RNA therapies), testing the most promising candidates in 3D brain models (iSpheroids) and eventually animal models to improve neuronal resilience against diseases like Alzheimer's, Parkinson's, and ALS.

via UC San Diego Today|

#aging-neurons #induced-neurons-ins #neurodegenerative-diseases

science6 months ago•7 min saved

OTULIN Regulates Tau in Neurons, Opening Alzheimer’s Therapy Avenues

Researchers at the University of New Mexico found that OTULIN, an enzyme known for immune regulation, also controls tau production in neurons. By inhibiting OTULIN with a small molecule or knocking out the OTULIN gene, they stopped new tau formation and cleared existing tau in human neuron models, suggesting a novel target for treating Alzheimer’s disease and related tauopathies. The findings also linked OTULIN to RNA metabolism and inflammatory pathways, and researchers note the need to study effects across different brain cell types before pursuing therapies.

via SciTechDaily|

#alzheimers-disease #brain-aging #neurodegenerative-diseases

health6 months ago•2 min saved

Microplastics and Lifestyle Factors Linked to Increased Risk of Brain Diseases

Neuroscientists warn that microplastics may contribute to neurodegenerative diseases like Alzheimer's by disrupting cellular pathways in the brain, emphasizing the need for reduced plastic use and better environmental policies to protect human health.

via The Cool Down|

#alzheimers #brain-health #environmental-pollution

health6 months ago•4 min saved

Scientists Successfully Reverse Alzheimer’s in Mice, Restoring Memory

A recent study demonstrates that restoring NAD+ levels in the brain can reverse Alzheimer's symptoms in mice, challenging the belief that the disease is irreversible and opening new possibilities for treatment and recovery in humans.

via Indian Defence Review|

#alzheimers #brain-health #cognitive-recovery

health7 months ago•3 min saved

A Natural Protein Boosts Brain Defense Against Alzheimer's

A study suggests that spermine, a natural molecule, may help clear toxic protein buildup in the brain associated with Alzheimer's and Parkinson's by promoting the formation of liquid-like protein droplets that are easier for the body's waste system to remove, showing promise in early tests with worms and cells, though more research is needed for human application.

via ScienceAlert|

#alzheimers #health #neurodegenerative-diseases

health8 months ago•3 min saved

Scientists Visualize Hidden Proteins and Triggers in Parkinson’s Disease

Researchers have developed a new imaging technique that allows for the first time the direct visualization and measurement of protein clusters called alpha-synuclein oligomers in human brain tissue, which are believed to initiate Parkinson's disease. This breakthrough could lead to earlier diagnosis and targeted treatments by revealing how the disease develops and spreads in the brain.

via Science Daily|

#alpha-synuclein-oligomers #brain-imaging #early-diagnosis

health8 months ago•2 min saved

Supercharged Vitamin K Shows Promise in Reversing Alzheimer’s Brain Damage

A Japanese study has developed a novel form of vitamin K that significantly enhances neuron formation and could potentially slow or reverse neurodegenerative diseases like Alzheimer's, offering a promising and safe new treatment avenue.

via Good News Network|

#alzheimers #drug-development #health

health9 months ago•4 min saved

Enhanced Vitamin K Boosts Brain Self-Healing

Researchers developed a potent vitamin K analogue that promotes neuronal differentiation and crosses the blood-brain barrier, offering a promising new approach for treating neurodegenerative disorders like Alzheimer's by potentially replenishing lost neurons and protecting brain function.

via ScienceDaily|

#brain-health #health #neurodegenerative-diseases

health9 months ago•2 min saved

New Molecule Shows Promise in Halting Parkinson’s Progress

Scientists have developed a molecule that prevents the harmful clumping of alpha-synuclein protein, a key factor in Parkinson's disease, showing promise in animal models and potentially paving the way for new treatments to slow or stop disease progression.

via ScienceDaily|

#health #molecule #neurodegenerative-diseases

science9 months ago•3 min saved

Scientists Stop Harmful Brain Protein Linked to Parkinson’s

Scientists in the UK have developed a peptide that stabilizes alpha-synuclein, a protein linked to Parkinson's and dementia, preventing harmful clumping in the brain. In animal models, this approach reduced protein buildup and improved movement, offering a promising avenue for future treatments of neurodegenerative diseases.

via SciTechDaily|

#alpha-synuclein #neurodegenerative-diseases #parkinsons

health9 months ago•3 min saved

Replacing Brain Immune Cells Shows Promise for Treating Neurodegenerative Diseases

Replacing old microglia with new ones in the brain could offer new treatments for neurological diseases like Alzheimer's and rare genetic disorders, but current methods involve risky procedures like chemotherapy or radiotherapy, limiting their use to severe conditions.

via Nature|

#brain-immune-cells #health #microglia

health10 months ago•3 min saved

Air Pollution Linked to Increased Risk of Dementia and Brain Health Issues

A large study links long-term exposure to PM2.5 air pollution with an increased risk of developing Lewy body dementia, especially in genetically predisposed individuals, with experiments in mice supporting the connection between pollution, protein buildup in the brain, and dementia development.

via Nature|

#air-pollution #dementia #health

health10 months ago•3 min saved

Air Pollution Linked to Increased Dementia Risk

Research suggests that fine-particulate air pollution (PM2.5) can trigger the formation of toxic protein clumps in the brain, leading to Lewy body dementia, and highlights the importance of improving air quality as a modifiable factor to prevent neurodegenerative diseases.

via The Guardian|

#air-pollution #dementia #health

health10 months ago•7 min saved

Gut health issues may signal early risk of Alzheimer's and Parkinson's

A large-scale study suggests that chronic gut problems, hormonal, metabolic, and nutritional issues like vitamin D deficiency may predict the risk of developing Alzheimer's and Parkinson's disease years before symptoms appear, highlighting the importance of early health markers and systemic health in disease prevention.

via Medical News Today|

#alzheimers #gut-brain-axis #health