Tag

Pdac

All articles tagged with #pdac

KRAS-targeting Pill Shows Promise Against Pancreatic Cancer
health2 months ago

KRAS-targeting Pill Shows Promise Against Pancreatic Cancer

A new oral drug, daraxonrasib, targets the KRAS gene in pancreatic ductal adenocarcinoma, showing in early Phase 1/2 data a median overall survival around 13 months and tumor shrinkage in some patients, nearly doubling survival compared with standard chemotherapy; however, about 30% experience severe side effects, and questions about access and cost remain as full Phase 3 results near disclosure at ASCO.

Triple KRAS Pathway Blockade Drives Complete Regression of Pancreatic Tumors in Preclinical Tests
science6 months ago

Triple KRAS Pathway Blockade Drives Complete Regression of Pancreatic Tumors in Preclinical Tests

Spanish researchers report a three-drug combo (RMC-6236/daraxonrasib, Afatinib, SD36) that simultaneously targets RAF1 (KRAS downstream), EGFR (upstream) and STAT3 signaling, producing complete regression of pancreatic tumors in orthotopic mouse models and patient-derived tissues with no resistance for more than 200 days, suggesting potential clinical trials for pancreatic ductal adenocarcinoma.