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Psa Testing

All articles tagged with #psa testing

PSA Alone Can Miss Prostate Cancer Growth; Regular Imaging Urged
medicine4 hours ago

PSA Alone Can Miss Prostate Cancer Growth; Regular Imaging Urged

In two major trials of enzalutamide for advanced prostate cancer, up to about 25% of patients showed radiographic progression on imaging despite stable or undetectable PSA levels, correlating with worse survival. The findings suggest PSA monitoring alone may miss disease growth, underscoring the value of periodic imaging—especially in the first two years—and may prompt updates to clinical guidelines. Possible mechanisms include tumors evolving to grow independent of androgen receptor signaling through lineage plasticity or neuroendocrine transformation.

 PSA screening may cut prostate cancer deaths, but benefits are modest and conditional
health1 month ago

PSA screening may cut prostate cancer deaths, but benefits are modest and conditional

A new Cochrane review finds PSA blood testing likely reduces death from prostate cancer with moderate certainty, reporting about two fewer disease-specific deaths per 1,000 men screened across six long-term European and North American trials. The benefit is modest and depends on careful implementation, ongoing medical follow-up, and selective biopsies to minimize overdiagnosis and overtreatment; the study does not issue guidelines but supports PSA screening in appropriately selected patients.

Early Signals: Subtle Prostate Cancer Symptoms Men 40+ Should Not Ignore
health4 months ago

Early Signals: Subtle Prostate Cancer Symptoms Men 40+ Should Not Ignore

Medical professionals warn that men over 40 should watch for early prostate cancer signs, including more frequent urination (especially at night), difficulty starting or stopping urine flow, a sense that the bladder won’t fully empty, blood in urine or semen, new erectile issues or painful ejaculation, persistent lower-back/hip/pelvic pain, and unexplained fatigue or weight loss. If symptoms persist for weeks, consult a GP promptly for assessment and potential PSA testing, with Prostate Cancer UK providing resources and support.

health5 months ago

Cambridge blood test could spark UK prostate cancer screening

Researchers at the University of Cambridge are developing a DNA methylation–based blood test that could not only detect prostate cancer but also indicate its aggressiveness and need for treatment, potentially underpinning a UK national screening programme. PSA tests currently used for screening are unreliable and UK advisers have urged targeted screening rather than broad population testing; a more accurate blood test could broaden screening, reduce unnecessary biopsies, and guide treatment decisions. The team plans UK clinical trials within 18–24 months and states the new test would complement, not replace, existing PSA testing. Prostate cancer is the UK’s most common cancer with about 12,000 deaths annually.

Detecting and Treating Metastatic Prostate Cancer in Men Over 70
health8 months ago

Detecting and Treating Metastatic Prostate Cancer in Men Over 70

The article discusses the complexities of screening and treating metastatic prostate cancer in men over 70, highlighting that while routine PSA testing is generally not recommended due to slow disease progression and potential treatment side effects, individual decisions should be made based on health status. It covers modern diagnostic tools like MRI and PSMA scans, advances in treatment such as hormone therapy, chemotherapy, and targeted radiation, and emphasizes that recent progress has improved survival rates and management of the disease in older men.

"Understanding Prostate Cancer: Expert Advice on Diagnosis"
health2 years ago

"Understanding Prostate Cancer: Expert Advice on Diagnosis"

Dr. Jamin Brahmbhatt emphasizes the importance of early detection for prostate cancer, with PSA testing being a vital tool for diagnosis. Regular screenings, especially for high-risk individuals, are crucial, and advancements in molecular urine and blood tests, imaging technology, and MRI technology have improved detection accuracy. Recent research and guidelines recommend earlier baseline PSA testing for Black men to address disparities in prostate cancer outcomes. Staying informed about screening guidelines and understanding individual risk factors is essential for proactive health care.

"The Prostate: Understanding its Impact on Men's Health"
health2 years ago

"The Prostate: Understanding its Impact on Men's Health"

The prostate, a small organ beneath the bladder, can cause problems for men as they age, with issues like an enlarged prostate (BPH) leading to urinary difficulties, and the potential for prostate cancer. Screening for prostate cancer using PSA testing has limitations and can lead to overdiagnosis and overtreatment, prompting disagreement among medical professionals about its overall benefits. Individual factors like family history, age, and race should be considered when discussing the risks and benefits of screening with a healthcare provider. Treatment options for prostate cancer range from active surveillance to removing or destroying the entire gland, with different approaches for different cases.