Tag

Transgenerational

All articles tagged with #transgenerational

Chernobyl’s Genetic Footprint: Mutations Found in Workers’ Children
science1 month ago

Chernobyl’s Genetic Footprint: Mutations Found in Workers’ Children

Researchers sequencing the genomes of Chernobyl cleanup workers and others exposed to ionizing radiation found clusters of new mutations in their children, with the strongest signal tied to paternal exposure. The findings suggest a potential transgenerational signature, but the estimated increase in genetic-disease risk is small and results come with uncertainties and validation challenges. More extensive studies, like the ongoing TRIO project, are planned to clarify the effect.

Dad's Preconception Drinking Alters Offspring Mitochondria, Study Finds
science2 months ago

Dad's Preconception Drinking Alters Offspring Mitochondria, Study Finds

Texas A&M researchers, backed by a $2.9 million NIH grant, are investigating how a father's alcohol consumption before conception can imprint non-genetic signals in sperm that disrupt offspring mitochondrial function, potentially leading to birth defects, chronic disease, and accelerated aging, while exploring interactions with maternal exposure and implications for other environmental stressors.

Radiation-exposed fathers linked to subtle DNA changes in their children
science6 months ago

Radiation-exposed fathers linked to subtle DNA changes in their children

A Scientific Reports study analyzing whole-genome data from 130 offspring of Chernobyl cleanup workers, 110 offspring of radar operators, and controls finds a higher count of clustered de novo mutations (cDNMs) in children of irradiated parents (average 2.65 per child in the Chernobyl group, 1.48 in the radar group, 0.88 in controls), with higher parental radiation dose associated with more cDNMs. Most cDNMs occur in non-coding DNA, suggesting minimal disease risk, and the overall risk of disease in offspring remains small. The study notes limitations, including historical exposure estimates and potential participation bias, and emphasizes a transgenerational effect of prolonged low-dose ionizing radiation.