Tag

Vitrification

All articles tagged with #vitrification

science20 days ago•3 min saved

Reviving Frozen Brain Slices Signals a Leap Toward Cryopreserved Organs

German researchers vitrified 350-micron mouse brain slices, cooled them to -320°F, and after thawing found intact neuronal membranes and preserved hippocampal long-term potentiation, with neurons still responsive to stimulation, suggesting brain function can resume after complete molecular shutdown and opening a path to organ preservation and potential cryopreservation of whole mammals, though translating this to humans and larger organs will require improved vitrification, cooling, and rewarming techniques.

via Futurism|

#cryopreservation #hippocampus #long-term-potentiation

science24 days ago•6 min saved

Vitrified Mouse Brains Show Signs of Life After Thaw

German researchers demonstrated vitrification-based cryopreservation of mouse brains, preserving tissue structure and neuronal activity enough for near-normal electrical responses and hippocampal long-term potentiation after thawing; whole brains were kept in a glass-like state at -140°C for up to eight days, yet linking preserved activity to memories and translating the approach to larger organs or human brains remains uncertain and technically challenging.

via Scientific American|

#brain #cryopreservation #hippocampus

science25 days ago•4 min saved

Cryopreserved brain tissue briefly reawakens, hinting at future organ preservation

German researchers vitrified thin mouse brain slices containing the hippocampus, then thawed them rapidly to reveal intact neural connections, active mitochondria, and responsive neurons, with evidence of long-term potentiation. They also tested preserving an entire mouse brain by circulating cryoprotectants, but viability was limited to hours and memory retention was not assessed. While the results hint at medical benefits such as slowing injury-related damage and enabling organ storage, the approach is early-stage and far from reviving whole brains or memories.

via New York Post|

#brain #cryopreservation #neuroscience

science28 days ago•5 min saved

Mouse hippocampus regains electrical activity after week-long vitrified freezing

Scientists chilled mouse hippocampal slices to a vitrified, glasslike state and stored them at −150°C for seven days before carefully warming them. When thawed, the tissue showed spontaneous synaptic activity and preserved neural structures, indicating functional recovery after extended freezing and suggesting vitrified suspended states can preserve neural circuitry in brain tissue (though this does not demonstrate memory preservation or viability of whole brains).

via The Daily Galaxy|

#cryopreservation #hippocampus #neuroscience

science1 month ago•6 min saved

Vitrified mouse brain slices briefly regain activity after thaw

German researchers demonstrate that ice-free vitrification can preserve and recover functional activity in mouse brain slices (including hippocampus) after thawing, with intact membranes, preserved mitochondrial activity, near-normal neuronal responses and lasting long-term potentiation for hours. While this marks the first demonstration of revived activity in frozen brain tissue, full brain function restoration and large-scale organ preservation remain out of reach due to ice-crystal damage, osmotic stress and cryoprotectant toxicity; the work hints at potential future applications in disease protection, organ banking and even whole-body cryopreservation, but is limited to slices and short observation windows.

via Nature|

#brain-slices #cryopreservation #hippocampus

science3 years ago•7 min saved

Mount Vesuvius' Eruption Turned Victims' Brains to Glass, Study Finds.

A new study has revealed the devastating impact of the eruption of Mount Vesuvius in AD 79 on inhabitants of Herculaneum. Researchers have found evidence that 'pyroclastic currents' hit the small Roman town, vaporising inhabitants within minutes. While most bodies at Herculaneum were swiftly reduced to piles of ash, scientists have previously found human tissue that was transformed to glass by the event. One man's brain had been burned at a very high temperature, before quickly cooling, turning it into a form of glass – a process known as vitrification.

via Daily Mail|

#archaeology #herculaneum #mount-vesuvius