Gut–brain interoception drives age-related cognitive decline
TL;DR
Researchers show that aging gut microbiota produce higher levels of medium-chain fatty acids, triggering peripheral inflammation via GPR84 and weakening vagal gut–brain signaling. This interoceptive dysfunction impairs hippocampal memory in aged mice, with promising interventions—phage targeting of Parabacteroides, GPR84 inhibitors, or boosting vagal activity—able to restore memory.
- Intestinal interoceptive dysfunction drives age-associated cognitive decline Nature
- The gut microbiome may influence brain aging, mouse study suggests Scientific American
- Enhancing gut-brain communication reverses cognitive decline and improves memory formation in aging mice Medical Xpress
- The gut can drive age-associated memory loss EurekAlert!
- Gut Microbes Contribute to Age-Related Cognitive Decline Inside Precision Medicine
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