Tag

Antisense Oligonucleotide

All articles tagged with #antisense oligonucleotide

health13 days ago•9 min saved

Biogen’s Diranersen Phase 2: Tau Reduction Shows Cognitive Signals Despite Missed Dose-Response Endpoint

Biogen reported that the Phase 2 CELIA trial of diranersen achieved robust reductions in CSF tau and tau pathology and showed slowing of cognitive decline across doses—most notably at 60 mg every 24 weeks—despite not meeting the primary dose-response endpoint (CDR-SB at Week 76). Safety was generally consistent with prior data, with more serious adverse events at the highest dose. Biogen plans to advance diranersen to registrational development and will present further data at AAIC 2026.

via Biogen|

#alzheimers-disease #antisense-oligonucleotide #biomarkers

science13 days ago•31 min saved

Keeping brain-repairing microglia active post-stroke enhances recovery

Ischemic stroke triggers reparative microglia that should aid recovery, but these cells later lose their reparative gene expression due to ZFP384 suppressing YY1-driven recovery-phase genes. The study shows antisense oligonucleotides targeting ZFP384 can sustain microglial reparative programs, prolonging neural repair and improving functional recovery even in chronic stroke, with IGF1 signaling playing a key role and human data showing ZFP384 inversely correlates with IGF1 in peri-infarct tissue.

via Nature|

#antisense-oligonucleotide #igf1 #microglia

health2 months ago•67 min saved

Promising antisense drug could alter Dravet syndrome in children

An early-stage trial suggests the antisense drug zorevunersen is safe for children with Dravet syndrome and may dramatically reduce seizures, with the highest-dose group seeing 59%–91% fewer seizures after about 20 months and potential neurodevelopmental and quality-of-life benefits. The study involved 81 children (ages 2–18) in the UK and US and did not include a placebo; larger, controlled trials are underway, with results expected by 2028 to determine if the treatment can alter the disease course.

via Live Science|

#antisense-oligonucleotide #dravet-syndrome #epilepsy

health4 months ago•2 min saved

Breakthrough in Targeting Pancreatic Cancer's Genetic Circuit

Researchers have identified a molecular circuit involving SRSF1, AURKA, and MYC that drives aggressive pancreatic cancer. They developed an antisense oligonucleotide that disrupts this circuit, causing cancer cells to die, which could lead to new treatments for pancreatic cancer in the future.

via ScienceDaily|

#antisense-oligonucleotide #aurka #health