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Bifidobacterium

All articles tagged with #bifidobacterium

Early gut microbiome stagnation triples type 1 diabetes risk in genetically susceptible children
health22 days ago

Early gut microbiome stagnation triples type 1 diabetes risk in genetically susceptible children

A new study in Nature Metabolism reveals that the trajectory of gut microbiome development in early childhood interacts with host genetics to predict type 1 diabetes (T1D) risk. Analyzing 887 high-risk children, researchers identified a specific 'Early Plateaued' microbiome pattern associated with a threefold increased risk of T1D. This risk is further modified by genetic variants related to immune responses, highlighting a critical window for early microbial exposure and genetic interplay in disease susceptibility.

via Nature|
#bifidobacterium#gut-microbiome#health
117-Year-Old's Gut Microbiome Hints at a Youthful Core
health-and-medicine3 months ago

117-Year-Old's Gut Microbiome Hints at a Youthful Core

Researchers studying María Branyas Morera, who died at 117, found her gut microbiome was dominated by Bifidobacterium (about half the community), a profile more typical of infants, and DNA methylation clocks suggested her biological age was 17–23 years younger than her actual age; the study, led by Dr. Manel Esteller at the Josep Carreras Leukaemia Research Institute, indicates gut health likely plays a role in aging but cautions that no single habit—like yogurt or diet—explains extreme longevity, which also depends on genetics and lifestyle.

via Sacramento Bee|
#aging#bifidobacterium#dna-methylation
Dietary choline fuels commensal acetylcholine to educate mucosal immunity
science4 months ago

Dietary choline fuels commensal acetylcholine to educate mucosal immunity

A multi-strain in vivo/vs in vitro comparison using PRESTO-Salsa reveals that gut commensals, notably infant-dominant Bifidobacterium breve and a Pediococcus strain, can convert dietary choline into acetylcholine (ACh) via bacterial ChAT-like enzymes BbChAT and PpChAT. This ACh production in the gut enhances intestinal IgA responses, reshapes microbial communities, and increases resistance to Salmonella infection; the effect is mediated mainly through nicotinic ACh receptors and requires choline as a substrate. The study identifies two previously uncharacterized hexapeptide-repeat acetyltransferases as ACh-synthesizing enzymes, demonstrates BbChAT’s role via a BbChAT knockout, and shows that ACh-producing B. breve offers a fitness and immune-education advantage in complex microbial communities, highlighting a diet–microbiome–host axis that strengthens mucosal defenses.

via Nature|
#acetylcholine#bifidobacterium#iga