
Common Sugar Alcohol in Diet May Boost Stroke Risk, Lab Finds
CU Boulder researchers found that erythritol, a sugar alcohol widely used in protein bars and zero-sugar drinks, altered brain blood vessel cells in vitro: less nitric oxide, more endothelin-1, and about 75% higher reactive oxygen species. When thrombin was introduced, erythritol also blunted tissue plasminogen activator (t-PA), reducing the body's ability to dissolve clots. The study echoes a 2023 epidemiological link between higher blood erythritol and stroke/heart attack risk, but authors caution that causality isn’t proven and endogenous production of erythritol may confound results, so continuing evaluation of non-nutrient sweeteners is prudent.













