Tag

Cancer Progression

All articles tagged with #cancer progression

health2 months ago•6 min saved

GLP-1 Weight-Loss Drugs Linked to Lower Breast Cancer Risk, Prompting New Trials

New observational studies presented at ASCO suggest GLP-1 medications used for diabetes and weight loss (e.g., semaglutide, liraglutide) are associated with a lower incidence of breast cancer and, among those diagnosed, reduced progression and mortality. While promising, the studies cannot prove causation, and researchers are planning randomized trials to test whether GLP-1 drugs can help prevent breast cancer or improve outcomes in high-risk individuals.

via ScienceAlert|

#asco #breast-cancer #cancer-prevention

health2 months ago•6 min saved

GLP-1 Weight-Loss Drugs Show Potential to Slow Cancer Spread in Real-World Study

A Cleveland Clinic retrospective study involving more than 12,000 patients suggests GLP-1 weight‑loss drugs (e.g., semaglutide, tirzepatide, dulaglutide, liraglutide, lixisenatide, pramlintide) may slow progression to advanced disease for several obesity‑related cancers (lung, breast, colorectal, liver), compared with DPP‑4 inhibitors. In four solid tumors, GLP‑1 users showed notably lower progression to stage 4 (up to 50% in non‑small cell lung cancer, 43% breast, 31% colorectal, 38% liver); prostate, pancreatic, and kidney cancers showed non‑significant trends. Tumors with higher GLP‑1 receptor expression also correlated with better survival. The study is not peer‑reviewed and cannot prove causation; randomized trials are needed to confirm mechanisms and effects.

via Fox News|

#asco-conference #cancer-progression #glp-1-drugs

health3 months ago•10 min saved

GLP-1 Diabetes Drugs Hint at Slowing Cancer Spread, Early Observational Findings

New findings from the Cleveland Clinic, presented at the ASCO meeting, suggest GLP-1 medications may be linked to reduced metastatic progression in several obesity-related cancers (notably non-small cell lung, breast, colorectal, and liver cancers) when compared with DPP-4 inhibitors. The study is observational and not peer‑reviewed, and it does not prove GLP-1s kill cancer cells or should be used for cancer prevention. Researchers caution that more rigorous, randomized trials are needed before changing cancer treatment guidelines.

via HuffPost|

#asco #cancer-progression #glp-1

technology3 months ago•55 min saved

Colon-on-a-chip uncovers stromal drivers, hormonal influences, and cancer risk in IBD

A colon-on-a-chip platform using patient-derived epithelium and fibroblasts reproduces healthy and IBD-like tissue, showing IBD fibroblasts drive barrier dysfunction, mucus changes, and inflammation. Peristalsis-like mechanical cues amplify fibrosis and inflammatory signaling in IBD chips, while female hormones exacerbate fibrosis and inflammation specifically in IBD tissues. Tissue-recombinant experiments confirm the stroma as the key driver of barrier breach and cytokine production. When exposed to the carcinogen ENU, IBD chips exhibit greater inflammation, loss of E-cadherin, nuclear β-catenin, and early cancer markers, along with copy-number changes, indicating heightened cancer-initiation risk. The model enables patient-specific studies and tests of stromal-focused therapies and sex-hormone effects on disease progression and cancer risk.

via Nature|

#cancer-progression #fibrosis #inflammatory-bowel-disease

health3 months ago•4 min saved

GLP-1 diabetes drugs linked to slower cancer progression in early study

An observational analysis of over 10,000 cancer patients who started GLP-1 drugs after diagnosis found slower progression in four of seven cancers, with the strongest effects in lung and breast cancer, compared with a matched group on DPP-4 inhibitors. The study is not peer‑reviewed and cannot prove causation; randomized trials are needed to confirm any anti‑cancer effects. Researchers discuss possible mechanisms, including tumor GLP-1 receptor interactions, interference with glycolysis, and immune modulation, and conclude GLP-1 drugs appear safe for patients with cancer using them for diabetes or obesity, though they are not a cancer therapy.

via NBC News|

#asco #cancer-progression #diabetes-drugs

health5 months ago•9 min saved

Gum-disease bacterium linked to faster breast cancer growth, study finds

A new study suggests a bacterium linked to gum disease can speed breast cancer tumor growth after entering the bloodstream, highlighting a potential connection between oral health and cancer progression.

via The Independent|

#breast-cancer #cancer-progression #gum-disease

science6 months ago•7 min saved

Tumor-Modulated Neutrophils Fuel Cancer Growth via CCL3

University of Geneva researchers find that neutrophils recruited to tumors are reprogrammed to produce the chemokine CCL3, which promotes tumor growth. This shift helps explain why some cancers become more aggressive and points to CCL3 activity in neutrophils as a potential prognostic biomarker and therapeutic target. The team used genetic tools to selectively suppress CCL3 in neutrophils and reanalyzed multiple studies to confirm the link.

via SciTechDaily|

#biomarker #cancer-progression #ccl3