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Cell Free Dna

All articles tagged with #cell free dna

AI-Driven Blood Test Detects Liver Cancer Across Diverse Populations
health26 days ago

AI-Driven Blood Test Detects Liver Cancer Across Diverse Populations

Johns Hopkins researchers validated an AI-powered DELFI liquid biopsy that detects liver cancer across two geographically and biologically distinct populations (Guatemala and Romania). When combined with AFP and basic risk factors, the test identified both early- and late-stage cancers with greater sensitivity than current blood tests, by analyzing genome-wide DNA fragment patterns that reflect signals from tumor, liver cells, blood vessels, and immune responses. The study also noted region-specific molecular signatures (e.g., aflatoxin-associated patterns in Guatemala) while the overall classifier remained effective across cancer causes. Future work will include prospective validation and integrating fragmentome analysis with other biomarkers for even earlier detection.

via News-Medical|
#artificial-intelligence#cell-free-dna#fragmentome
MethylScan: A Low-Cost Blood Test for Early, Multi-Disease Detection
biotechnology4 months ago

MethylScan: A Low-Cost Blood Test for Early, Multi-Disease Detection

UCLA researchers report MethylScan, a simple, affordable test that analyzes DNA methylation in circulating cell-free DNA to detect multiple cancers and liver diseases, and to indicate tissue of origin and organ health. In 1,061 samples, it achieved about 98% specificity, ~63% cancer detection across stages (~55% for early-stage) and ~80% detection of liver cancers in high‑risk groups, with a sequencing depth of ~300× costing under $20 per test as costs fall. By reducing background DNA, it functions as a system-wide health monitor, though larger prospective studies are needed to confirm real-world effectiveness.

via SciTechDaily|
#biotechnology#cancer-detection#cell-free-dna
cf-EpiTracing maps disease origin and therapy responses from the plasma epigenome
science5 months ago

cf-EpiTracing maps disease origin and therapy responses from the plasma epigenome

Researchers report cf-EpiTracing, an automated platform that profiles multiple histone modifications in cell-free chromatin from as little as 50 μL of plasma to infer tissues of origin with high accuracy; by integrating an 18-ICS ChromHMM framework across reference epigenomes, it identifies primary diseased tissues, detects organ involvement, enables noninvasive cancer subtyping (DLBCL, FL, MCL), early colorectal lesions, prognosis and therapy-response prediction, and tracks disease transformations and translocations. Validated in CRC, CHD and B-cell lymphoma cohorts, cf-EpiTracing outperforms current clinical indices for prognosis and supports longitudinal monitoring, highlighting a versatile, noninvasive epigenome-centric approach that could be integrated with other cfDNA modalities for enhanced precision.

via Nature|
#cell-free-dna#cf-epitracing#epigenomics