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Epigenomics

All articles tagged with #epigenomics

Dominant clones co-opt developmental epigenomics to drive paediatric ependymoma
science16 days ago

Dominant clones co-opt developmental epigenomics to drive paediatric ependymoma

A multi-omics study in mouse and human ependymoma reveals that ZFTA–RELA fusion co-opts brain-development PLAG/L motif–driven chromatin programs in cycling progenitors to sustain oncogenic gene expression, driving dominant tumor clones that establish the cancer's cellular hierarchy across species; lineage tracing shows early clonal diversity converging on a single dominant lineage, highlighting PLAG/L networks as potential therapeutic targets and suggesting differentiation-based strategies.

via Nature|
#clonal-evolution#ependymoma#epigenomics
cf-EpiTracing maps disease origin and therapy responses from the plasma epigenome
science1 month ago

cf-EpiTracing maps disease origin and therapy responses from the plasma epigenome

Researchers report cf-EpiTracing, an automated platform that profiles multiple histone modifications in cell-free chromatin from as little as 50 μL of plasma to infer tissues of origin with high accuracy; by integrating an 18-ICS ChromHMM framework across reference epigenomes, it identifies primary diseased tissues, detects organ involvement, enables noninvasive cancer subtyping (DLBCL, FL, MCL), early colorectal lesions, prognosis and therapy-response prediction, and tracks disease transformations and translocations. Validated in CRC, CHD and B-cell lymphoma cohorts, cf-EpiTracing outperforms current clinical indices for prognosis and supports longitudinal monitoring, highlighting a versatile, noninvasive epigenome-centric approach that could be integrated with other cfDNA modalities for enhanced precision.

via Nature|
#cell-free-dna#cf-epitracing#epigenomics
Aging Decoded: 7-Million-Cell Atlas Maps Coordinated Decline Across 21 Organs
science1 month ago

Aging Decoded: 7-Million-Cell Atlas Maps Coordinated Decline Across 21 Organs

Researchers mapped nearly 7 million cells from 21 mouse organs at three ages to create the most detailed aging atlas yet, finding that aging proceeds in a synchronized, body-wide fashion with about a quarter of cell types changing in abundance and notable sex differences; the study also identified shared DNA-regulatory hotspots and cytokine-linked changes that could become targets for therapies aiming to slow aging across multiple organs.

via ScienceDaily|
#aging#anti-aging-therapy#epigenomics
Mapping the Complexity: Unveiling the Multi-Omic Atlas of the Mouse Brain
science-and-technology2 years ago

Mapping the Complexity: Unveiling the Multi-Omic Atlas of the Mouse Brain

Researchers have created a comprehensive atlas of the adult mouse brain, mapping the DNA methylome and 3D genome at single-cell resolution. The study utilized enhanced single-nucleus methylation sequencing and chromatin conformation capture sequencing to analyze DNA methylomes and the 3D genome in detail. The dataset identified 4,673 cell groups and provided a multi-omic resource for understanding the molecular architecture of the mouse brain. The study deepens insights into the epigenetic and transcriptomic intricacies that underpin brain function and diseases.

via Nature.com|
#brain-function#dna-methylation#epigenomics