Imputing Fluid Intelligence Scores Boosts UK Biobank Genetic Discovery
Researchers have developed a method to impute fluid intelligence scores for UK Biobank participants who did not take cognitive tests, expanding the sample size from approximately 270,000 to over 455,000. This approach increases the power to detect genetic associations, identifying 550 independent common SNP associations and 26 genes linked to rare variants. The method also reduces ascertainment bias caused by the higher education levels of those who originally completed the tests.