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Duloxetine

All articles tagged with #duloxetine

science11 days ago•8 min saved

Most sugar substitutes disrupt gut bacteria and trigger surprising drug interactions

A Cambridge study tested 39 sweeteners against 25 gut bacteria and found that roughly 75% affected at least one strain; mixing sweeteners with common compounds (caffeine, vanillin, and the antidepressant duloxetine) produced over 100 new interactions, some disruptive, suggesting sugar substitutes can alter the gut microbiome and interact with medications; the WHO notes non-sugar sweeteners show no proven long-term weight‑loss benefits.

via ZME Science|

#artificial-sweeteners #drug-interactions #duloxetine

science1 month ago•5 min saved

Sweeteners can disrupt gut bacteria, especially when paired with medications

Cambridge researchers screened 39 sweeteners on 25 gut bacteria and found most affected at least one species, with more than 100 interactions when combined with other substances (such as caffeine, vanillin, and duloxetine). The most striking result was that isosteviol together with the antidepressant duloxetine strongly suppressed two key gut bacteria and lowered microbial diversity in a synthetic community. All experiments were conducted in the lab, so human health relevance remains to be established.

via ScienceDaily|

#duloxetine #gut-microbiome #isosteviol

life-sciences1 month ago•11 min saved

Common sweeteners can disrupt gut bacteria, especially with medications, Cambridge study finds

Cambridge researchers showed in vitro that common sweeteners slow growth of several gut bacteria; most notably, the isosteviol–duloxetine combination strongly suppressed Roseburia intestinalis and Parabacteroides merdae, reducing microbial diversity and altering interactions with host cells. The team tested 25 bacterial species against 39 sweeteners and examined interactions with substances like caffeine, vanillin, and eight drugs, uncovering over 100 interaction effects. Although the findings suggest that sweeteners can affect gut microbes—especially when mixed with other compounds—these were lab experiments and real-world health implications require further study.

via News-Medical|

#duloxetine #gut-bacteria #gut-microbiome

health2 months ago•3 min saved

Generic antidepressant recall due to nitrosamine cancer risk

Breckenridge Pharmaceuticals recalled certain lots of duloxetine (generic Cymbalta) after FDA testing found nitrosamine levels above the agency’s limit, affecting 30 mg (exp. Apr 2027, Lot 241180C) and two 60 mg lots (Feb 2026 Lot 230286C; Feb 2027 Lot 24072lC). Patients should contact their doctor or pharmacist and not stop taking the medication without medical guidance.

via NBC New York|

#cancer-risk #duloxetine #fda

health2 months ago•23 min saved

Cymbalta recalled over nitrosamine cancer-risk contamination

Nearly 370,000 bottles of duloxetine (Cymbalta) are being recalled after the FDA flagged levels of the nitrosamine contaminant N-nitroso-duloxetine that exceed safety limits, potentially increasing long-term cancer risk. The Class II recall covers 30 mg and 60 mg bottles with specific lot codes; no adverse effects have been reported yet. Patients should consult their healthcare provider before stopping the medication abruptly, as withdrawal can occur.

via New York Post|

#cymbalta #duloxetine #fda

health1 year ago•2 min saved

FDA Recalls Antidepressant Over Cancer Concerns

The FDA has issued a recall for the antidepressant duloxetine due to potential cancer risks. Patients using this medication are advised to consult their healthcare providers for alternative treatments and to discuss any concerns regarding their current prescriptions.

via First For Women|

#antidepressant #cancerrisk #duloxetine

health3 years ago•2 min saved

The Effectiveness of Antidepressants for Chronic Pain: What the Studies Say

Antidepressants commonly used to treat chronic pain lack evidence as to whether or not they work, researchers have said, declaring the situation a global public health concern. A new Cochrane review has revealed there is little evidence whether or not amitriptyline and many other common antidepressants work when it comes to tackling chronic pain. The team found that many of the trials involved very small numbers of patients, making the results unreliable. Only duloxetine and milnacipran had enough evidence for the researchers to have even moderate confidence in their findings, with the drugs found to have a small to moderate effect on substantial pain relief.

via The Guardian|

#amitriptyline #antidepressants #chronic-pain