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Alcohol Use Disorder

All articles tagged with #alcohol use disorder

GLP-1s for Addiction: Early Signals, Still Many Questions
health9 days ago

GLP-1s for Addiction: Early Signals, Still Many Questions

Glucagon-like peptide-1 receptor agonists, originally used for diabetes and obesity, are being explored as addiction treatments. Early data from animal studies, observational research, and some randomized trials suggest GLP-1s may dampen reward-driven cravings and reduce alcohol consumption, with semaglutide showing reductions in craving and heavy drinking in alcohol use disorder; results for opioid, cocaine, and nicotine use disorders are less robust and mostly preclinical. The drugs likely act on shared brain reward pathways and may broadly decrease reward seeking, not just addiction-specific cravings. Many critical questions remain about which patients benefit, optimal dosing and duration, durability after stopping, interactions with comorbidities, and equitable access. Large, longer-term trials are ongoing, and GLP-1s are not yet ready to replace established addiction treatments.

via Medscape|
#addiction#alcohol-use-disorder#glp-1
GLP-1 Medications Show Promise in Alcohol Use Disorder, Awaiting Approval
health1 month ago

GLP-1 Medications Show Promise in Alcohol Use Disorder, Awaiting Approval

A Danish Lancet trial found the GLP-1 drug semaglutide reduced alcohol consumption and heavy drinking days over 26 weeks, adding to a growing body of research that GLP-1s may curb cravings for various substances. However, these drugs are not approved for alcohol use disorder and are prescribed today for diabetes or obesity; ongoing studies in the U.S. and elsewhere are exploring effects on other addictions and whether benefits persist after stopping treatment. If future trials confirm efficacy and safety, GLP-1s could become a treatment option pending regulatory approval.

via Gizmodo|
#addiction#alcohol-use-disorder#clinical-trials
Anterior Insula Bias Pushes Rats Toward Alcohol Over Social Rewards
science4 months ago

Anterior Insula Bias Pushes Rats Toward Alcohol Over Social Rewards

In rats, heightened anterior insula activity just before choosing correlates with a bias toward alcohol over social rewards, revealing a neural mechanism that could explain the prioritization seen in alcohol use disorder and identifying the anterior insula as a potential target for interventions to restore balanced decision-making.

via Neuroscience News|
#addiction#alcohol-use-disorder#anterior-insula
Tirzepatide reduces alcohol reward in rodent study, hinting at AUD therapy
science4 months ago

Tirzepatide reduces alcohol reward in rodent study, hinting at AUD therapy

Rodents treated with tirzepatide (Mounjaro) drank more than half as much alcohol as controls, showed fewer relapse-like drinking episodes, and exhibited reduced alcohol-induced dopamine spikes in the brain’s reward center, the lateral septum. The drug also altered histone-related proteins, suggesting possible long-term neural changes. While promising, human trials are needed to confirm efficacy for alcohol use disorder, though tirzepatide’s established safety profile could speed future research.

via Neuroscience News|
#alcohol-use-disorder#dopamine#glp-1gip-dual-agonist
Old AUD Medications Remain Underused as GLP-1 Buzz Grows
health4 months ago

Old AUD Medications Remain Underused as GLP-1 Buzz Grows

Three FDA-approved meds (naltrexone, acamprosate, disulfiram) can treat alcohol use disorder but are widely underused due to stigma, limited clinician training, and marketing gaps, with only a fraction of diagnosed patients receiving them; meanwhile GLP-1 weight‑loss drugs (like Ozempic) are being studied for reducing drinking, but evidence is not yet conclusive, underscoring the need to treat alcohol use disorder like other chronic diseases by improving access and awareness.

via Business Insider|
#acamprosate#alcohol-use-disorder#disulfiram
GLP-1 Diabetes Drugs Offer Hope in Addiction Recovery Pilot
health4 months ago

GLP-1 Diabetes Drugs Offer Hope in Addiction Recovery Pilot

A Rhode Island nonprofit’s Open Doors pilot is giving free weekly GLP-1 injections (semaglutide–based) to women in addiction recovery, with participants reporting reduced cravings, steadier thinking, and improved life stability. While some studies hint GLP-1s dampen the rewarding effects of drugs and alcohol, the medications are not FDA-approved for addiction and funding for the pilot runs for 18 months, raising questions about long-term access. Experts urge cautious optimism, noting risks if treatment is stopped and that this is not a universal cure.

via The Boston Globe|
#addiction#alcohol-use-disorder#glp-1
GLP-1 Diabetes Drugs Show Promise in Reducing Alcohol Consumption
health1 year ago

GLP-1 Diabetes Drugs Show Promise in Reducing Alcohol Consumption

GLP-1 receptor agonist drugs like Ozempic, initially used for weight loss, are showing potential in reducing cravings for alcohol and other substances. Studies indicate that these drugs may lower the risk of alcohol use disorder and reduce nicotine and opioid overuse by influencing dopamine pathways in the brain. While not yet approved for treating substance use disorders, these drugs could revolutionize addiction treatment if further research supports their efficacy. Experts are hopeful that GLP-1 drugs could become a major tool in addiction therapy, similar to how SSRIs transformed depression treatment.

via National Geographic|
#addiction-treatment#alcohol-use-disorder#glp-1-drugs
"Semaglutide Shows Promise in Reducing Alcohol Use Disorder"
health2 years ago

"Semaglutide Shows Promise in Reducing Alcohol Use Disorder"

A study by Case Western Reserve University found that diabetes drugs Wegovy and Ozempic, which contain semaglutide, significantly reduce the risk and recurrence of alcohol-use disorder by 50%-56%. This discovery suggests a potential new treatment for AUD, though further clinical trials are needed to confirm these findings.

via Neuroscience News|
#alcohol-use-disorder#case-western-reserve-university#clinical-trials