All articles tagged with #granulocyte monocyte progenitors
Researchers engineered macrophage progenitor cells to self-renew and differentiate into macrophages for CAR-M therapy. Using GMPs, they produced a persistent immune cell supply that spread through the body in mice and slowed both blood cancers and solid tumors, offering a scalable alternative to CAR-T for broader cancer immunotherapy.
USC researchers developed a stem-cell–inspired method to expand granulocyte-monocyte progenitors (GMPs), enabling long-term self-renewal and genetic engineering to produce macrophages that can target cancer. Engineered GMPs carrying a CAR and an additional immune-activating signal demonstrated tumor-fighting activity and sustained production of immune cells in mice, suggesting a scalable, off-the-shelf cellular immunotherapy with potential applications beyond cancer.