Tag

Karolinska Institutet

All articles tagged with #karolinska institutet

health1 month ago

Gut Bacteria Convert Vegetable Nutrients into Heart-Protecting Molecules

Researchers at Karolinska Institutet have identified a new mechanism by which vegetables benefit health: gut bacteria convert dietary nitrate and plant-based iron into dinitrosyl iron complexes (DNICs). Published in Cell, the study shows these molecules travel to organs like the liver and kidneys, where they improve cardiovascular and metabolic markers in animal models. While the findings explain part of why vegetable-rich diets reduce disease risk, human trials are needed to confirm the pathway's relevance in people.

Psilocybin shows rapid mood improvement in recurrent depression in new trial
science4 months ago

Psilocybin shows rapid mood improvement in recurrent depression in new trial

A small randomized trial at Karolinska Institutet tested a single 25 mg dose of psilocybin versus placebo, with structured psychological support, in 35 participants with recurrent depression not classified as treatment-resistant, and followed them for a year. By day eight, mood improvements appeared in the psilocybin group; by six weeks, more than half no longer met criteria for depression versus one in the placebo group, though self-rated benefits persisted for about three months. About one-third in each arm began antidepressants during follow-up, reflecting real-world care. Two participants in the psilocybin group experienced severe anxiety requiring medical attention. Limitations include small sample size and unblinding concerns, but the study broadens the potential target population for psychedelic-assisted therapy and underscores the need for larger trials and scalable regulatory frameworks for implementation.

New 47-Year Study Pinpoints When Fitness Begins to Fade (In Your 30s)
science9 months ago

New 47-Year Study Pinpoints When Fitness Begins to Fade (In Your 30s)

A long-running Swedish SPAF study of 427 participants shows peak physical capacity in the mid-30s, with a rise in decline after age 40 and about 30–40% loss by age 63 across aerobic fitness, endurance, and power. Lifelong activity—especially starting in youth or re-engaging later—significantly boosts outcomes and slows deterioration, but the onset of decline appears biologically programmed well before later life, highlighting the value of staying active early in life.

Heart Meds May Protect Against Dementia, While Painkillers Pose Risks
health1 year ago

Heart Meds May Protect Against Dementia, While Painkillers Pose Risks

A study by Karolinska Institutet suggests that long-term use of common cardiovascular drugs, such as antihypertensives and cholesterol-lowering medications, may reduce the risk of dementia in older adults by up to 25%. However, antiplatelet drugs like aspirin could increase dementia risk due to potential brain microbleeds. The findings highlight the need for further research into drug combinations and preventive strategies for dementia.