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Lac Phe

All articles tagged with #lac phe

health4 days ago•6 min saved

Experimental Pill Tries to Turn Exercise Into a Daily Tablet

Enveda’s ENV-308 is an experimental daily pill designed to mimic some effects of exercise by delivering Lac-Phe to suppress appetite. In a Phase 1 trial with 88 healthy adults, the drug was safe and well tolerated across dose levels, with an “exceptional” gastrointestinal safety profile. Lac-Phe is a natural compound formed when lactate and phenylalanine combine during exercise and can reduce hunger, but it degrades quickly; ENV-308 aims to prolong these effects and potentially complement GLP-1 weight-loss drugs. Animal studies suggest it may preserve lean muscle during weight loss. Next steps include trials to test actual weight and metabolic outcomes and interactions with other therapies. Even if successful, it will take years and FDA approval before it could reach patients, and it won’t replace the benefits of physical activity.

via New York Post|

#env-308 #exercise-pill #glp-1

science6 days ago•3 min saved

Could an Exercise Pill Pass Its First Human Safety Check? ENV-308

Enveda’s ENV-308, a pill designed to mimic the exercise-linked molecule Lac-Phe, successfully completed a Phase I trial in 88 healthy volunteers, showing safety, tolerability, and an exceptional GI safety profile. Early signs suggest it may influence leptin levels and aid weight maintenance and muscle preservation, with Phase II planned for weight-loss maintenance and exploration in migraines and inflammatory bowel disease. It’s not a substitute for real exercise, but could offer a convenient metabolic aid as development continues.

via Gizmodo|

#env-308 #exercise-pill #lac-phe

biotech7 days ago•2 min saved

Oral lac-phe pill aims to mimic exercise, preserving muscle during weight loss in early trials

Enveda reports Phase 1 results for an oral drug candidate that mimics the exercise-induced lactate-phenylalanine pathway (lac-phe) to curb appetite and preserve lean muscle, with the goal of maintaining weight loss without the GI side effects seen with GLP-1 drugs.

via statnews.com|

#biotech #enveda #exercise-mimetic

science4 months ago•6 min saved

Metformin Sparks Exercise-Mode Metabolism in Prostate Cancer Care

Researchers report metformin increases Lac-Phe, a molecule tied to energy use and appetite, in prostate cancer patients who aren’t exercising, mimicking an exercise signal and potentially supporting metabolic health during treatment; the effect is not linked to tumor control and requires further study.

via SciTechDaily|

#exercise-signal #lac-phe #metabolic-health

science10 months ago•4 min saved

Scientists Find Natural Molecule That Suppresses Hunger

Scientists discovered that Lac-Phe, a molecule produced during exercise, suppresses appetite by acting on specific brain neurons, offering potential new avenues for weight management treatments.

via SciTechDaily|

#appetite-suppression #brain-neurons #exercise

health-and-science10 months ago•2 min saved

Innovative Weight Loss Method Mimics Exercise Effects

A new study suggests that intense exercise produces a metabolite called Lac-Phe in mice, which may suppress appetite by affecting brain neurons, offering potential for future weight management drugs. While promising, further research is needed to determine if this mechanism works similarly in humans.

via ScienceAlert|

#appetite-suppression #exercise #health-and-science

health-and-medicine2 years ago•5 min saved

"Unveiling Metformin's Role in Natural Appetite Control for Weight Loss"

Researchers have discovered that the molecule lac-phe, abundant after intense exercise, is responsible for the weight loss effects of the diabetes drug metformin, linking it to appetite control and metabolism. Metformin increases lac-phe levels, mirroring the effects of vigorous exercise, potentially paving the way for new weight loss drugs. The study, published in Nature Metabolism, reveals that metformin stimulates lac-phe production, leading to reduced hunger and weight loss, offering insights into potential pathways for developing effective weight loss treatments.

via SciTechDaily|

#appetite-control #exercise #health-and-medicine