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Opioids

All articles tagged with #opioids

Tramadol’s limited relief vs. rising risks prompt a rethink of its use for chronic pain
health26 days ago

Tramadol’s limited relief vs. rising risks prompt a rethink of its use for chronic pain

A BMJ Evidence-Based Medicine review analyzed 19 randomized trials (6,506 participants) and found tramadol provides only modest, likely non-meaningful relief for chronic pain while doubling the risk of harm versus placebo—predominantly heart-related events—with common side effects such as nausea, dizziness, and constipation. Many included studies carried biases that may overstate benefits and understate harms; a questionable signal for cancer risk was noted due to short follow-up. Overall, the potential harms appear to outweigh the limited benefits, underscoring a need to rethink tramadol’s role in chronic-pain care amid broader opioid concerns.

via Earth.com|
#adverse-effects#cardiovascular-risk#chronic-pain
Pediatric Journal Reveals 138 Fictional Case Reports, Sparking Global Corrections
health2 months ago

Pediatric Journal Reveals 138 Fictional Case Reports, Sparking Global Corrections

A pediatric journal admitted that 138 published case reports were fictional, created under a confidentiality program to protect patients; at least 61 of these cases have been cited as fact in other journals, prompting corrections, scrutiny of potential retractions, and concern over how misinformation spread, including the controversial 'baby boy blue' opioid-in-breast milk case. Editors say future reports will clearly label cases as fictional, but copies and citations in databases like PubMed Central and Semantic Scholar have already propagated the error.

via Gizmodo|
#corrections#health#medical-ethics
Global Review Questions Opioids as Go-To for Acute Pain
health2 months ago

Global Review Questions Opioids as Go-To for Acute Pain

A sweeping analysis of 59 systematic reviews across more than 50 acute-pain conditions finds opioids provide only modest, short‑term relief for some cases and little or no benefit for others, while raising risks of side effects and misuse; the study calls for safer alternatives and careful, limited prescribing rather than using opioids as the default treatment for acute pain.

via SciTechDaily|
#acute-pain#drug-safety#health
Federal probe shadows Jim Irsay's death and its treatment questions
national4 months ago

Federal probe shadows Jim Irsay's death and its treatment questions

The death of Indianapolis Colts owner Jim Irsay is under federal investigation by the FBI and DEA, examining the circumstances of his May death at the Beverly Hills Hotel and the involvement of a California addiction specialist who treated him with opioids and ketamine; the death certificate cites cardiac arrest due to pneumonia with no autopsy, and the probe is in its early stages while the Colts say they have not been contacted by authorities.

via abc7.com|
#beverly-hills-hotel#federal-investigation#jim-irsay
health4 months ago

Trump Admin Slices $1.9B in Mental Health and Addiction Grants, Reshaping SAMHSA

The Trump administration terminated about 2,800 discretionary SAMHSA grants worth roughly $1.9 billion as of Jan. 13, aimed at realigning the agency’s portfolio toward innovative programs; the cuts threaten access to mental health and addiction services, complicate 2026 funding negotiations, and come amid SAMHSA staffing declines, with potential funding gaps if Congress does not act before Jan. 30.

via Politico|
#budget#grants#health
Gene Therapy Targets Pain Circuits to Relieve Chronic Pain Without Addiction
science4 months ago

Gene Therapy Targets Pain Circuits to Relieve Chronic Pain Without Addiction

A preclinical CNS-targeted gene therapy dampens pain signals in specific brain circuits to relieve chronic pain while avoiding the brain reward pathways tied to addiction, using AI-guided imaging and animal models, with an off switch for long-lasting relief and moving toward clinical trials to help the roughly 50 million Americans affected by chronic pain.

via SciTechDaily|
#addiction#gene-therapy#neuroscience
Scientists Find Safer Method for Pain Relief Without Opioid Risks
health4 months ago

Scientists Find Safer Method for Pain Relief Without Opioid Risks

Scientists at USF Health have discovered new ways opioid receptors can function, potentially leading to pain medications that provide effective relief without the dangerous side effects like respiratory depression, by favoring a reverse signaling pathway. This research could pave the way for safer, non-addictive pain treatments and improve understanding of receptor mechanisms.

via SciTechDaily|
#health#opioids#pain-relief