Tag

Adverse Effects

All articles tagged with #adverse effects

health1 month ago•17 min saved

High-Dose GLP-1 Drugs May Dim Joy, Doctors Warn

Doctors report three cases of anhedonia (loss of pleasure) in people taking the obese‑treating GLP-1 drug tirzepatide at very high doses (up to 15 mg/week). In all cases, symptoms eased after reducing the dose (and in one case adding an antidepressant), suggesting the effect is dose-related and manageable. The side effect is linked to GLP-1s’ influence on brain reward regions like the ventral tegmental area, though GLP-1 therapies remain associated with reduced depression symptoms overall. Clinicians emphasize monitoring motivation and pleasure during treatment, especially at higher doses, and note that this should not deter indicated use for obesity or type 2 diabetes while remaining vigilant and adjusting dosing as needed.

via Gizmodo|

#adverse-effects #anhedonia #glp-1s

health3 months ago•36 min saved

Tramadol’s limited relief vs. rising risks prompt a rethink of its use for chronic pain

A BMJ Evidence-Based Medicine review analyzed 19 randomized trials (6,506 participants) and found tramadol provides only modest, likely non-meaningful relief for chronic pain while doubling the risk of harm versus placebo—predominantly heart-related events—with common side effects such as nausea, dizziness, and constipation. Many included studies carried biases that may overstate benefits and understate harms; a questionable signal for cancer risk was noted due to short follow-up. Overall, the potential harms appear to outweigh the limited benefits, underscoring a need to rethink tramadol’s role in chronic-pain care amid broader opioid concerns.

via Earth.com|

#adverse-effects #cardiovascular-risk #chronic-pain

health5 months ago•8 min saved

Large review finds medicinal cannabis rarely aids mental health and raises side-effect risk

A comprehensive analysis of 54 randomized trials (2,477 participants) finds medicinal cannabis provides little to no benefit for depression, anxiety, PTSD and other mental health disorders, while adverse effects are about 75% more likely. Some signals for cannabis use disorder, insomnia, Tourette’s, and autistic traits were noted but of low quality. The researchers caution against routine medicinal cannabis for mental health, noting it can delay proven treatments, and acknowledge cannabis has established benefits for epilepsy, multiple sclerosis, and certain types of pain.

via Fox News|

#adverse-effects #cannabis #health

science5 months ago•6 min saved

Meditation’s hidden risk: over 10% report serious adverse effects

A 2022 US study found that more than 10% of regular meditators report significant adverse effects—such as anxiety, depersonalization, or psychosis—that can disrupt daily functioning for a month or more. The findings echo long-standing warnings in Buddhist texts and contrast with the mindfulness industry’s promotion of benefits, as some research shows no mental-health gains or even harm for vulnerable groups.

via Boing Boing|

#adverse-effects #meditation #mental-health

science6 months ago•6 min saved

Mindfulness Has a Dark Side: Adverse Effects Are More Common Than We Realize

New research shows mindfulness and meditation can trigger adverse effects such as anxiety, depression, psychotic symptoms, and dissociation, even in people without prior mental-health issues, with a major UK study finding no mental-wellbeing benefit for at‑risk youths. The piece calls for ethical warnings, safer practice guidelines, and greater awareness of potential harm in the mindfulness industry.

via ScienceAlert|

#adverse-effects #meditation #mental-health

health6 months ago•57 min saved

UK reports triple-digit rise in Mounjaro side effects in 2025, with 71 deaths

UK health chiefs recorded 40,245 adverse reactions to the diabetes/weight-loss jab Mounjaro in 2025 (6,755 serious; 71 deaths), a roughly 340% rise from 2024. Gastrointestinal disorders were the most common reaction (37,546 reports, 19 fatal). The NHS notes symptoms like nausea and diarrhea, while patients report severe side effects. Eli Lilly says safety is a priority and that risks are monitored. The MHRA updated product info to include a small risk of severe acute pancreatitis for Mounjaro (as well as Wegovy and Ozempic). Regulators stress benefits often outweigh risks, and urge patients to consult doctors about side effects. In the UK, around 1.6 million people are said to have used these lipids-lowering injections in the past year.

via Daily Mail|

#adverse-effects #health #mhra

health8 months ago•3 min saved

Study Finds Common Painkiller Offers Limited Relief and Increased Health Risks

A recent study published in BMJ Evidence-Based Medicine found that tramadol, a commonly prescribed opioid for chronic pain, offers minimal pain relief and poses significant health risks, including serious cardiovascular events, leading experts to question its use for long-term pain management.

via KTVU|

#adverse-effects #chronic-pain #health

health10 months ago•5 min saved

New Study Questions Tramadol's Effectiveness and Safety for Chronic Pain

A recent systematic review suggests that tramadol provides minimal pain relief for chronic pain conditions while doubling the risk of serious side effects, mainly cardiac issues, leading experts to recommend reconsidering its use for such cases.

via Medscape|

#adverse-effects #chronic-pain #health

health1 year ago•5 min saved

Research Team Accuses Pfizer of Concealing Vaccine Fatalities

A research team alleges that Pfizer concealed two deaths during its COVID-19 vaccine clinical trials, potentially indicating dangerous side effects. The deaths, one in Kansas and another in Georgia, were not reported in a timely manner, raising concerns about the trial's integrity and the vaccine's safety. The researchers argue that these omissions could have influenced the vaccine's emergency use authorization and highlight potential cardiovascular risks associated with the vaccine. The findings suggest Pfizer may have been aware of these risks before the vaccine's approval.

via The Sentinel|

#adverse-effects #clinical-trials #covid-19-vaccine

health2 years ago•2 min saved

Study Finds Slight Increase in Heart and Brain Disorders Linked to COVID-19 Vaccines

The largest COVID-19 vaccine study involving nearly 100 million people across eight countries has found a link between the Pfizer, Moderna, and AstraZeneca vaccines and slight increases in neurological, blood, and heart-related conditions. While the study emphasizes that the association between the vaccines and adverse side effects does not prove causation, it prompts individuals to consider their medical condition and need for protection. Dr. Jonathan Kantor, an expert in clinical epidemiology, stresses that while vaccines have risks, their benefits still outweigh the potential risks, and the decision to get vaccinated should be based on individual circumstances.

via WJXT News4JAX |

#adverse-effects #covid-19-vaccine #global-covid-vaccine-safety-project

health-covid-192 years ago•2 min saved

Global Study Finds Small Increase in Heart and Brain Disorders Linked to COVID Vaccines

A multi-country study of nearly 100 million vaccinated individuals found links between COVID-19 vaccines and increased risks for adverse effects such as myocarditis and Guillain-Barré syndrome. The study, conducted by the Global COVID Vaccine Safety project, looked at recipients of Pfizer, Moderna, and AstraZeneca vaccines across eight countries and identified higher-than-expected instances of certain adverse events. The researchers emphasized the importance of considering the risk associated with COVID-19 infection when evaluating the risk-to-benefit ratio of vaccination.

via WJW FOX 8 News Cleveland|

#adverse-effects #covid-19-vaccines #global-covid-vaccine-safety-project

health-vaccines2 years ago•2 min saved

"COVID Vaccine Study: Potential Adverse Effects and Risk Comparison"

A study of nearly 100 million vaccinated individuals across eight countries found links between COVID-19 vaccines and increased risks for adverse effects such as myocarditis and Guillain-Barré syndrome. The study, conducted by the Global COVID Vaccine Safety project, specifically looked at adverse events following administration of Pfizer, Moderna, and AstraZeneca vaccines. While the study identified safety signals, it emphasized the rarity, severity, and clinical relevance of these adverse events and highlighted the importance of considering the overall risk-benefit evaluations of vaccination in the context of the risks associated with SARS-CoV-2 infection.

via Yahoo News|

#adverse-effects #covid-19-vaccines #global-covid-vaccine-safety-project

health-medicine2 years ago•3 min saved

"Link Between COVID Vaccines and Heart Ailments Revealed in New Study"

A peer-reviewed study published in Therapeutic Advances in Drug Safety found shocking rates of COVID-19 shot-induced myocarditis, especially in males between the ages of 0 and 30, with 3078 reports of COVID-19 vaccine-induced myocarditis, 76% resulting in emergency care and hospitalization, and 3% resulting in death. The study calls for further investigation into the underlying mechanisms of COVID-19 vaccine-induced myocarditis to ensure the safety of COVID-19 vaccination programs across populations.

via CatholicVote org|

#adverse-effects #covid-19-vaccine #health-medicine

health2 years ago•1 min saved

The Health Risks of Excessive Smartphone Use in Teens

A study conducted by researchers from Hanyang University Medical Center in South Korea reveals that teenagers who use smartphones for more than four hours a day are more likely to experience adverse mental health and substance use. The study analyzed data from over 50,000 Korean adolescents and found that excessive smartphone use was associated with higher rates of stress, suicidal thoughts, obesity, and substance use. Interestingly, those who used their phones for only one to two hours faced fewer issues than those who did not use their phones at all. The study highlights the need for guidelines regarding smartphone usage among teenagers.

via Yahoo News|

#adverse-effects #health #mental-health

healthcare2 years ago•7 min saved

Calls to Reverse Antidepressant Prescribing in the UK Gain Momentum

A group of medical professionals, researchers, patient representatives, and politicians are urging the UK government to reverse the rate of antidepressant prescribing, which has nearly doubled in England over the past decade. They highlight the adverse effects and withdrawal symptoms associated with long-term use of antidepressants, as well as the lack of improvement in mental health outcomes at the population level. The group calls for public health recommendations to be implemented, including stopping the prescribing of antidepressants for mild conditions, adhering to safe prescribing and withdrawal management guidelines, and funding withdrawal services integrated with non-pharmacological interventions. They also suggest reducing antidepressant prescribing as an indicator in healthcare quality frameworks and establishing a national prescribed drug withdrawal helpline and website.

via The BMJ|

#adverse-effects #antidepressant-prescribing #healthcare