Tag

Personalized Therapies

All articles tagged with #personalized therapies

health-policy1 month ago•3 min saved

FDA Unveils Plausible Mechanism Framework to Accelerate Tailored Therapies for Ultra-Rare Diseases

The FDA issued a draft guidance outlining a Plausible Mechanism Framework to accelerate approvals of genome-editing and RNA-based, individualized therapies that target the root causes of ultra-rare diseases, allowing smaller, robust studies and the use of master protocols. Sponsors must demonstrate the therapy addresses the specific disease mechanism, rely on well-characterized natural history data, and show target engagement or editing; public comments are due within 60 days.

via fda.gov|

#fda #genome-editing #health-policy

health2 years ago•3 min saved

"Uncovering Five Variants of Alzheimer's Disease: A Potential Breakthrough in Treatment"

Scientists have identified five distinct biological variants of Alzheimer's disease, each with specific alterations in clusters of proteins related to inflammation, nerve cell growth, and other biological processes. This breakthrough discovery could lead to more personalized therapies or preventive measures for these subtypes, as well as hope for early diagnosis and intervention to delay the onset of symptoms of Alzheimer's disease. The research team used updated technology to analyze cerebrospinal fluid proteins and identified variations such as hyperplasticity, immune activation, RNA dysregulation, choroid plexus dysfunction, and blood-brain barrier impairment. This finding suggests that medications already tested may have falsely seemed to be ineffective or only slightly effective, and that some drugs may only work in specific Alzheimer's types.

via ScienceAlert|

#alzheimers-disease #biological-variants #early-diagnosis

science-and-research2 years ago•6 min saved

The Gendered Impact of Stress: Unveiling the Enormous Implications

A new study using advanced methods to analyze gene expression in individual brain cells reveals that male and female mice respond differently to stress, highlighting the importance of diversity in scientific research. The findings could lead to personalized therapies for stress-related conditions such as anxiety, depression, and obesity. The study emphasizes the need for including both male and female researchers and animals in experiments to obtain a more complete understanding of stress-related health conditions.

via SciTechDaily|

#diversity-in-research #gender-differences #mice-study

health2 years ago•4 min saved

Epstein-Barr Virus Antibodies Implicated in Multiple Sclerosis Progression.

Antibodies against the Epstein-Barr virus (EBV) can mistakenly target proteins in the brain and spinal cord, leading to multiple sclerosis (MS) symptoms, according to a study by researchers at Karolinska Institutet in Sweden. The study found that this antibody misdirection was present in roughly 23% of MS patients studied. The findings highlight the need for personalized therapies to combat MS, which is a complex disease.

via Neuroscience News|

#antibodies #epstein-barr-virus #health