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Porphyromonas Gingivalis

All articles tagged with #porphyromonas gingivalis

health10 days ago•9 min saved

Gum Bacteria Linked to Heart Valve Calcification

Preliminary human tissue and mouse studies suggest Porphyromonas gingivalis, a gum-disease bacterium, may contribute to calcific aortic valve stenosis (CAVS) by triggering IL-1β–driven inflammation. The bacterium was more often found in calcified heart valves, and in mice, exposure to the bacteria increased valve calcium buildup and signs of stenosis, which were reduced by antibiotics or by blocking the IL-1β inflammatory pathway. While these findings show an association and a potential mechanism, they do not prove causation in people; researchers are pursuing clinical studies and emphasize that maintaining oral health could benefit overall cardiovascular health.

via SciTechDaily|

#aortic-valve-calcification #calcific-aortic-valve-stenosis #health

health-and-medicine14 days ago•7 min saved

Gum-Disease Bacteria May Drive Calcified Heart Valve Damage, New Research Finds

Researchers traced Porphyromonas gingivalis, a gum-disease bacterium, to calcific aortic valve stenosis by showing it can accumulate in the aortic valve and drive inflammation and calcium buildup in mice; antibiotics reduced the effect, and deleting IL-1β lessened calcification, hinting at a biological link between periodontal disease and heart valve damage. The findings are preliminary (not yet peer-reviewed) and human studies are underway, but experts say good oral health could benefit heart health.

via ScienceDaily|

#calcific-aortic-valve-stenosis #gum-disease #health-and-medicine

health2 months ago•263 min saved

Bean-Gum Chewing Gum Targets Cancer-Linked Oral Microbes, Trials Ahead

Researchers have developed a chewing gum made from lablab bean proteins that could help fight head and neck cancer by reducing oral microbes linked to the disease. In ex vivo tests, the gum lowered HPV levels by about 93% in saliva, and when bioengineered to include an antimicrobial peptide, it nearly eliminated Porphyromonas gingivalis and Fusobacterium nucleatum without disturbing beneficial mouth bacteria. The approach targets infection locally at the site of cancer risk and could complement existing therapies. Trials are being planned in London and at the University of Pennsylvania in the U.S. to evaluate its effectiveness in HNSCC patients.

via AOL.com|

#chewing-gum #fusobacterium-nucleatum #head-and-neck-cancer

biotechnology-dentistry4 months ago•8 min saved

Microbiome-Safe Toothpaste Targets Gum Disease Without Killing Beneficial Bacteria

Researchers have developed a microbiome-friendly toothpaste that uses a targeted compound to inhibit the gum-disease pathogen Porphyromonas gingivalis without disrupting the broader oral microbiome, allowing beneficial bacteria to rebalance the mouth and potentially reduce periodontitis. The approach, developed with PerioTrap and Fraunhofer institutes, also spawns post-cleaning products like a care gel, with ongoing development of additional oral-care solutions.

via SciTechDaily|

#biotechnology-dentistry #gum-disease #microbiome

health2 years ago•2 min saved

The Oral-Gut Connection: Exploring the Link Between Infection and Alzheimer's

A growing body of scientific research suggests that Alzheimer's disease may be caused by an infection, with one study linking the pathogen Porphyromonas gingivalis, responsible for gum disease, to the brains of deceased Alzheimer's patients. In experiments with mice, oral infection with the bacteria led to brain colonization and increased production of amyloid beta, a protein associated with Alzheimer's. The researchers also identified toxic enzymes called gingipains secreted by the bacteria in the brains of Alzheimer's patients, even in those who were never diagnosed with the disease. A compound called COR388 showed promise in reducing bacterial load and amyloid-beta production in mice. Further research is needed to fully understand the link between gum disease and Alzheimer's.

via ScienceAlert|

#alzheimers-disease #amyloid-beta #bacterial-infection