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Fusobacterium Nucleatum

All articles tagged with #fusobacterium nucleatum

health28 days ago•263 min saved

Bean-Gum Chewing Gum Targets Cancer-Linked Oral Microbes, Trials Ahead

Researchers have developed a chewing gum made from lablab bean proteins that could help fight head and neck cancer by reducing oral microbes linked to the disease. In ex vivo tests, the gum lowered HPV levels by about 93% in saliva, and when bioengineered to include an antimicrobial peptide, it nearly eliminated Porphyromonas gingivalis and Fusobacterium nucleatum without disturbing beneficial mouth bacteria. The approach targets infection locally at the site of cancer risk and could complement existing therapies. Trials are being planned in London and at the University of Pennsylvania in the U.S. to evaluate its effectiveness in HNSCC patients.

via AOL.com|

#chewing-gum #fusobacterium-nucleatum #head-and-neck-cancer

health3 months ago•7 min saved

Oral Bacteria May Accelerate Breast Cancer by Reaching Breast Tissue

A Johns Hopkins study shows Fusobacterium nucleatum, a mouth bacterium linked to gum disease, can travel to breast tissue via the bloodstream, causing inflammation, DNA damage, and cell changes that accelerate tumor growth and spread in mouse models, with BRCA1-mutant breast cells especially vulnerable; findings suggest oral microbes may influence breast cancer risk and progression.

via SciTechDaily|

#brca1 #breast-cancer #dna-damage

health4 months ago•6 min saved

Oral Bacteria Linked to Increased Disability in Multiple Sclerosis Patients

Research suggests that high levels of the oral bacterium Fusobacterium nucleatum may be linked to increased disability in multiple sclerosis patients, indicating a possible MS-specific oral–brain inflammatory pathway and highlighting the importance of oral health in disease progression.

via Neuroscience News|

#fusobacterium-nucleatum #health #multiple-sclerosis

health2 years ago•6 min saved

Link Found Between Oral Bacteria and Aggressive Colorectal Cancer

Fusobacterium nucleatum, an oral bacterium, has been linked to the development and progression of colorectal cancer by binding to cancer cells and activating growth factors that promote cancer proliferation and metastasis. Maintaining good oral hygiene is crucial in managing this bacterium, reducing the risk of gum disease and its potential systemic health impact. Scientists are exploring ways to develop screening tools and therapies to neutralize the threat posed by Fusobacterium nucleatum, emphasizing the importance of oral health in preventing inflammation and keeping harmful oral bacteria at bay.

via Verywell Health|

#cancer-research #colorectal-cancer #fusobacterium-nucleatum

health2 years ago•1 min saved

"Link Between Oral Bacteria and Accelerated Colon Cancer Growth Uncovered"

Research shows that a specific subtype of the oral bacterium Fusobacterium nucleatum, known as Fna C2, is linked to the growth of colon tumors and is more prevalent in colon cancer patients. This finding could lead to new insights into fighting colon cancer and the development of targeted therapies. The discovery of this bacterial subtype's association with colorectal cancer is crucial for the development of effective preventive and treatment methods.

via Yahoo! Voices|

#cancer-research #colon-cancer #fusobacterium-nucleatum

health2 years ago•2 min saved

"Link Between Oral Bacteria and Accelerated Colorectal Cancer Growth Identified"

A study has found that a specific subtype of the oral bacterium Fusobacterium nucleatum, known as Fna C2, can travel from the mouth to colon tumors and accelerate their growth. This discovery could lead to new insights into combating colon cancer, which claims over 52,000 lives in the U.S. annually. The presence of Fna C2 was linked to poorer prognosis in colorectal cancer patients, and researchers suggest that targeting this bacterial subgroup could improve treatment and prevention methods, potentially through microbe-based cellular therapies.

via UPI News|

#cancer-research #colon-cancer #fusobacterium-nucleatum

health-cancer-research2 years ago•4 min saved

"Discovery of Aggressive Bacteria in Half of Colon Cancer Cases"

A study published in Nature found that a type of bacteria, Fusobacterium nucleatum, typically found in the mouth, was discovered in 50% of colorectal tumors and appears to shield tumor cells from cancer-fighting drugs. This discovery could lead to new treatments and screening methods for colorectal cancer, which is on the rise, particularly among younger people. The bacteria's stealthy subspecies was found to worsen prognosis and may even cause cancer to form. The findings could lead to targeted therapies, including antibiotics and potentially genetically modifying the bacteria to carry cancer-fighting drugs directly into tumors.

via AOL|

#bacteria #cancer-treatment #colorectal-cancer

medical-research2 years ago•77 min saved

New Fusobacterium Nucleatum Clade Found in 50% of Aggressive Colon Cancers

A study reveals that a specific clade within the Fusobacterium nucleatum (Fn) subspecies dominates the colorectal cancer (CRC) niche, with in vitro and in vivo studies demonstrating its high virulence in the context of CRC. Comparative genomics and functional studies show that this clade, known as Fna clade 2 (Fna C2), is significantly associated with the CRC niche and possesses distinct genetic and epigenetic characteristics compared to Fna clade 1 (Fna C1). Fna C2 is enriched in CRC tumors and exhibits differential invasion potential and morphological differences compared to Fna C1, shedding light on its potential role in CRC pathogenicity.

via Nature.com|

#clade #colorectal-cancer #fusobacterium-nucleatum