All articles tagged with #prucalopride
A small randomized trial found that prucalopride, a serotonin 5-HT4 receptor agonist used for chronic constipation, improved memory, attention, and executive function in adults with a history of depression after seven to ten days of treatment, with no significant side effects, suggesting potential repurposing to treat cognitive deficits in depression.
A study from the University of Birmingham and University of Oxford found that prucalopride, a laxative used for constipation, improved performance on tests of focus, attention, planning, short- and long-term memory, and emotional cognition in 50 participants with depressive episodes. Participants (aged 18–40) received 2 mg of the drug or placebo for 7–10 days, with cognitive assessments before and after; the drug acts on the 5HT4 serotonin receptor in the gut-brain axis, suggesting potential new treatment avenues for cognitive symptoms of depression.
A new study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging has found that prucalopride, a drug that activates serotonin type 4 receptors, enhances functional connectivity between major cognitive networks in the brain. This provides a possible explanation for why drugs targeting these receptors have been shown to improve cognitive function. The findings suggest that drugs like prucalopride could be potential treatments for psychiatric conditions involving cognitive problems, such as depression. However, further research is needed to determine the effectiveness of prucalopride in individuals with depression and cognitive deficits.
A recent study has found that prucalopride, a common laxative that activates serotonin receptors, improves cognitive function and memory in healthy volunteers by modifying resting brain activity. The drug enhances connectivity between cognitive networks and decreases mind-wandering activity, providing a potential treatment path for cognitive impairment and depression symptoms. The study suggests that drugs like prucalopride may offer potential therapeutic benefits for cognitive symptoms, which often coexist with mood disorders and other psychiatric conditions.
A study has found that prucalopride, a laxative known to activate serotonin receptors, can enhance cognitive function and memory by increasing functional connectivity between major cognitive networks in the brain. The drug also reduced connectivity in the brain's default mode network, which is activated during mind wandering. The results suggest that prucalopride and drugs impacting the 5-HT4 serotonin receptor could be potential treatments for depression and cognitive impairment.