Tag

Sasp

All articles tagged with #sasp

science2 hours ago•6 min saved

Mitochondrial Epigenetics Quiet Chronic Inflammation in Aging Cells

Mayo Clinic researchers link aging “zombie” cells’ persistent inflammation to a two‑part mechanism: damaged mitochondria leak immune-activating DNA/RNA to trigger inflammatory signals, and increased mitochondrial metabolism raises acetyl‑CoA, enabling epigenetic changes that make inflammatory genes more accessible. Blocking the mitochondrial citrate transporter SLC25A1 cuts acetyl‑CoA supply and dampens SASP-driven inflammation even with ongoing immune signaling, offering a way to reduce aging‑related inflammation without destroying the cells.

via SciTechDaily|

#acetyl-coa #epigenetics #mitochondria

science1 month ago•48 min saved

Multi-omic Regulation of Cellular Senescence

Nature Reviews Genetics surveys how genomic, epigenomic and transcriptomic programs coordinate the induction, maintenance and heterogeneity of cellular senescence, highlighting the DNA damage response and non-genotoxic stress, epigenetic remodeling and SASP-driven intercellular signaling, while calling for next-generation biomarkers and single‑cell multi-omics approaches to accurately identify and target senescent cells.

via Nature|

#aging #cellular-senescence #dna-damage-response

science1 month ago•83 min saved

Mitochondrial citrate metabolism governs aging-related inflammation via epigenetic SASP control

A recent study finds that senescent cells rely on the mitochondrial citrate–acetyl‑CoA axis to maintain histone acetylation at SASP gene loci, supporting inflammatory output. Inhibiting citrate export (SLC25A1) or the mitochondrial pyruvate carrier reduces acetyl‑CoA supply, lowers SASP gene expression, and dampens inflammation without reversing senescence, which in aged mice translates to improved healthspan. The mtDNA–cGAS–STING inflammatory pathway and mitochondrial metabolic control function as independent but complementary inputs to SASP, revealing a mitochondrial–epigenetic checkpoint that could be targeted to mitigate aging-related inflammation.

via Nature|

#acetyl-coa #aging #histone-acetylation