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Tuberculosis

All articles tagged with #tuberculosis

Johns Hopkins Develops Nasal DNA Vaccine to Augment TB Treatment
science2 days ago

Johns Hopkins Develops Nasal DNA Vaccine to Augment TB Treatment

Johns Hopkins Medicine researchers have created a therapeutic, intranasal DNA vaccine against tuberculosis by fusing RelMtb with Mip3α. When used with standard TB drug therapy, it strengthened lung and systemic immunity, sped bacterial clearance, reduced lung inflammation, and prevented relapse in mice, with durable immune responses observed in nonhuman primates, suggesting a path toward human trials and the potential to shorten TB treatment, including for drug-resistant strains.

via Good News Network|
#dna-vaccine#intranasal#johns-hopkins
Massive TB exposure traced to Sheba Medical Center prompts health response
health12 days ago

Massive TB exposure traced to Sheba Medical Center prompts health response

A pulmonary TB patient stayed in Sheba Medical Center's underground surgical unit (March 17–22, 2026), exposing about 750 patients (including around 300 newborns) and roughly 1,900 staff, plus unknown visitors. Health authorities and Sheba launched an epidemiological investigation; exposed individuals will receive Mantoux skin tests, with preventive antibiotics for positives. Infants under age 3 and immunocompromised people will begin four months of antibiotics immediately. Visitors with more than eight hours of exposure are advised to contact the Health Ministry hotline. TB is airborne, with higher risk after prolonged exposure, and the situation will be monitored and updated.

via Israel National News|
#exposure-investigation#health#mantoux-test
U.S. TB Cases Climb as Latent Infections Reactivate Post-Pandemic
health12 days ago

U.S. TB Cases Climb as Latent Infections Reactivate Post-Pandemic

Tuberculosis, known as the white plague, is rising in the United States after COVID-19 disrupted screening and treatment, with 2024 TB cases topping 10,600—the highest since 2013. Health officials say many infections are latent and undiagnosed, reactivating as screenings resume and international travel/migration rebounds. About 25% of people are infected with TB, but 5%–10% progress to active disease. TB is curable with antibiotics, but incomplete treatment risks drug resistance; higher-risk groups include people born in or traveling to TB-burden countries, those living in crowded conditions, and immunocompromised individuals. Emphasis is on testing and treating latent TB to prevent progression to active disease.

via Yahoo|
#cdc#health#latent-tb
Tuberculosis Stages a Modern Comeback in the U.S., Raising Drug-Resistance Fears
health17 days ago

Tuberculosis Stages a Modern Comeback in the U.S., Raising Drug-Resistance Fears

TB is resurging in the United States, with provisional 2025 data showing 10,260 cases nationwide (967 in New York). The disease often exists as latent infections (up to 13 million nationwide) that can activate, fueling spread and antibiotic resistance (589 cases resistant to at least one frontline drug in 2023). Active and latent TB require long antibiotic regimens (6–9 months), and early detection plus vaccination considerations are key to prevention. Globally TB remains one of the deadliest infectious diseases, underscoring the ongoing public-health challenge in America and beyond.

via New York Post|
#antibiotic-resistance#cdc#health
New TB Antibiotics Target Bacteria’s Protein Recycling, Offering Hope Against Drug-Resistant TB
science17 days ago

New TB Antibiotics Target Bacteria’s Protein Recycling, Offering Hope Against Drug-Resistant TB

Researchers analyzed three experimental anti-TB compounds—ecumicin, ilamycins, and cyclomarins—and found they all disrupt the M. tuberculosis protein-recycling machine ClpC1-ClpP1P2, each in a different way, causing widespread disturbances across thousands of bacterial proteins and triggering stress responses (ecumicin notably raises Hsp20). This mechanistic mapping provides a clearer path to designing more precise anti-TB drugs as drug-resistant TB remains a major global threat; the work was published in Nature Communications.

via ScienceAlert|
#antibiotic-resistance#clpc1-clpp1p2#cyclomarins
WHO backs near-point-of-care TB tests and tongue swabs to speed diagnosis
health18 days ago

WHO backs near-point-of-care TB tests and tongue swabs to speed diagnosis

WHO endorses portable, near-point-of-care TB tests that are battery-powered and deliver results in under an hour, plus tongue-swab sampling and sputum pooling to expand testing, cut costs, and start treatment sooner; the guidance, released for World TB Day 2026, calls for urgent scale-up and sustained investment as funding gaps threaten progress, with potential benefits for testing other diseases as well.

via World Health Organization (WHO)|
#diagnostics#health#point-of-care
Tuberculosis makes a quiet comeback in the United States
health18 days ago

Tuberculosis makes a quiet comeback in the United States

Vox’s Future Perfect reports that tuberculosis is rising in the United States as latent infections awaken into active disease, with outbreaks surfacing in places like Archbishop Riordan High School in San Francisco, Long Island, and Seattle. The piece argues that TB remains a global health threat and that domestic progress depends on a strong public-health infrastructure, timely diagnosis, access to preventive therapy, and sustained funding for research and treatment. Delays, drug shortages, and the high cost of care threaten prevention and risk more outbreaks and drug resistance, underscoring the need for new diagnostics, vaccines, and policy action to curb TB at home and worldwide.

via Vox|
#health#infectious-disease#latent-tuberculosis
No Additional Tuberculosis Cases Linked to Patchogue-Medford HS as Suffolk Health Investigates
health2 months ago

No Additional Tuberculosis Cases Linked to Patchogue-Medford HS as Suffolk Health Investigates

Suffolk County health officials say one active tuberculosis case has been identified in the Patchogue-Medford High School community; the investigation is ongoing, with free testing offered to potentially exposed individuals and tests conducted at the high school on Jan. 28 and 30, with a follow-up in March after the two‑month incubation period. No additional cases have been identified and privacy protections are in place.

via Patch|
#contact-tracing#health#mantoux-test
TB outbreak at Bay Area Catholic high school prompts hybrid return plan
health2 months ago

TB outbreak at Bay Area Catholic high school prompts hybrid return plan

San Francisco public health officials report a tuberculosis outbreak at Archbishop Riordan High School, with three active TB cases and 50 latent infections, leading to classroom cancellations and a hybrid return plan; officials say the risk to the wider population is low, even as California faces rising TB activity and emphasizes screening and treatment to reduce spread.

via Los Angeles Times|
#archbishop-riordan-high-school#health#latent-tuberculosis-infection
Tuberculosis resurges in the UK, with the North East hardest hit
health2 months ago

Tuberculosis resurges in the UK, with the North East hardest hit

UK Health Security Agency data show tuberculosis cases rose in recent years, with 5,424 cases in 2025 (up 25% from 2022), though 2024 had the highest total at 5,480; the disease mainly attacks the lungs and is linked to poverty, with the North East seeing the strongest rise; 65 drug-resistant TB cases were reported; experts urge rapid diagnosis and treatment to curb spread, noting TB’s historic toll on figures like Emily Brontë and George Orwell.

via Daily Express|
#health#north-east-england#poverty
Riordan High School halts in-person classes amid SF tuberculosis outbreak
health2 months ago

Riordan High School halts in-person classes amid SF tuberculosis outbreak

Riordan High School in San Francisco canceled on-campus classes after the SF Department of Public Health confirmed three active TB cases since November. The school moved to online/hybrid learning while testing and contact tracing proceed; tested students can begin hybrid online/in-person classes on Feb. 9, with a full hybrid schedule through Feb. 20 and non-tested staff or students barred from campus afterward.

via missionlocal.org|
#health#public-health#riordan-high-school