All articles tagged with #tubulin
Scientists at Baylor College of Medicine report that tubulin can prevent Tau and alpha-synuclein from forming toxic aggregates in brain cells by redirecting these proteins toward healthy microtubule functions, offering a potential therapeutic strategy that boosts tubulin levels rather than halting droplet formation to preserve normal neuronal activity.
A Baylor College of Medicine study suggests increasing cellular tubulin can steer Tau and alpha-synuclein away from harmful aggregates toward healthy microtubule activity, offering a potential therapeutic strategy for Alzheimer’s and Parkinson’s by boosting tubulin rather than blocking condensate formation.
Researchers from EPFL and the University of Geneva have developed "designer tubulins" with specific post-translational modifications (PTMs) to gain insights into the functions of tubulin in cells. By engineering tubulins with precise combinations of PTMs, the team discovered an interaction between two key PTMs, polyglutamylation and detyrosination, which play crucial roles in diseases. This new method of producing tubulins with defined PTMs can advance our understanding of their molecular function and provide insights into how dysregulation of these PTMs leads to diseases.