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Ebv

All articles tagged with #ebv

Severe COVID may awaken dormant viruses, fueling long-COVID questions
health7 hours ago

Severe COVID may awaken dormant viruses, fueling long-COVID questions

A study of 1,154 adults hospitalized with COVID-19 found that severe infection can reactivate dormant viruses in the body, including EBV, CMV, HSV and anelloviruses. Nearly half (about 550 participants) showed at least one reactivation, with different viruses turning on at different times and linking to immune/metabolic changes and persistent long-COVID symptoms in some patients. While these findings suggest a potential role for viral reactivation in disease severity and long COVID, the authors stress that RNA detection shows association, not causation, and call for prospective interventional trials to test whether antiviral treatment could improve outcomes.

via Live Science|
#anelloviruses#covid-19#ebv
Host genetics and daily rhythms shape the human DNA virome
science5 months ago

Host genetics and daily rhythms shape the human DNA virome

A massive multi-cohort study analyzed DNA viral load for 31 viruses in blood and saliva, finding that viral load varies with age, sex, time of day, and season, and is higher in men. Genome-wide associations implicate dozens of loci, especially in the MHC/HLA region, and genes like ERAP1/ERAP2 in shaping EBV, HHV-7, HHV-6B and other viral loads, with notable virus-specific effects and EBV subtype interactions. Saliva shows frequent lytic bursts for some herpesviruses, contrasting with blood. Mendelian randomization suggests higher EBV DNA load may causally increase Hodgkin’s lymphoma risk but not multiple sclerosis, highlighting a host-genome influence on the circulating DNA virome and its disease connections; the findings also reveal ancestry- and tissue-specific patterns and circadian/seasonal dynamics.

via Nature|
#dna-virome#ebv#hlamhc
Epstein-Barr Virus Linked to Increased Cancer Risk and Systemic Effects
health1 year ago

Epstein-Barr Virus Linked to Increased Cancer Risk and Systemic Effects

A new WHO study reveals that the Epstein-Barr virus (EBV), which infects most people worldwide, significantly increases the risk of developing various cancers, especially nasopharyngeal cancer, lung cancer, liver cancer, and lymphomas, with the risk rising in proportion to antibody levels. The findings highlight the importance of understanding EBV's role in cancer development and encourage further research into its mechanisms.

via Euronews.com|
#cancer-risk#ebv#health
"Discovery: Abundant T-Cell Response to EBV-Infected B-Cells in MS Patients"
health2 years ago

"Discovery: Abundant T-Cell Response to EBV-Infected B-Cells in MS Patients"

A study found that people with multiple sclerosis (MS) have high levels of T-cells in their spinal fluid that specifically target cells infected with the Epstein-Barr virus (EBV), suggesting a potential link between EBV and MS. The findings may help shed light on the processes that drive MS, as infection with EBV has been identified as one of the strongest risk factors for developing MS. The study's data suggest that these T-cells may be either causing the disease or contributing to it, and further research is ongoing to better understand the biological activity of these EBV-specific T-cells.

via Multiple Sclerosis News Today|
#ebv#health#immune-system
"Latest MS News: EBV, DMT Discontinuation, and Treatment Updates"
multiple-sclerosis-ms2 years ago

"Latest MS News: EBV, DMT Discontinuation, and Treatment Updates"

Research presented at the joint meeting of ECTRIMS and ACTRIMS suggests that a combination of faulty immune regulation, genetics, and specific strains of the Epstein-Barr virus (EBV) may increase the risk of developing MS. Stopping disease-modifying therapy (DMT) can lead to new disease activity, as shown in a study that had to be ended early due to participants experiencing increased disease activity. Encouraging treatment reports include the potential of foralumab to ease brain inflammation in secondary progressive MS, fenebrutinib's ability to reduce new inflammatory lesions in relapsing MS, and ongoing efforts to find ways to curb MS progression.

via Multiple Sclerosis News Today|
#disease-modifying-therapy-dmt#ebv#ms-progression
The Link Between Epstein-Barr Virus and Multiple Sclerosis Explored in New Study
health3 years ago

The Link Between Epstein-Barr Virus and Multiple Sclerosis Explored in New Study

A new study has found that when the immune system fights off the Epstein-Barr virus (EBV), immune cells can mistakenly target a protein called CRYAB that is normally expressed by healthy myelin-making cells in the brain, which could explain the link between EBV and multiple sclerosis (MS). The study found that certain antibodies against EBV can mistakenly target the brain and spinal cord and cause damage. The researchers also found that cross-reactivity between CRYAB and EBV may play a role in MS, and patients positive for antibodies against both proteins were nine times more likely to have MS.

via Multiple Sclerosis News Today|
#antibodies#cross-reactivity#ebv
The Lingering Impact of Viruses.
health3 years ago

The Lingering Impact of Viruses.

Viruses like herpes, HIV, Epstein-Barr, and others can cause long-term health issues, including chronic conditions like cancer and autoimmune diseases. Long COVID is the latest long-term condition caused by a virus, and researchers are studying its similarities to other post-viral fatigue ailments. While some viruses are transient and go away quickly, others like EBV can linger for years or even a lifetime. There are currently over 300 clinical trials for long COVID treatments, and prevention options like Paxlovid and metformin are showing promise. Long COVID specialty clinics are now available in every state except South Dakota and Kansas.

via Fred Hutch News Service|
#autoimmunity#chronic-conditions#ebv
One Shot Could End Multiple Sclerosis and Kissing Disease Forever, Say Scientists.
health3 years ago

One Shot Could End Multiple Sclerosis and Kissing Disease Forever, Say Scientists.

Researchers have found a link between the Epstein-Barr virus (EBV), which causes mono, and multiple sclerosis (MS). While most people will get EBV at some point, only a small percentage will develop MS. However, researchers believe that developing a vaccine against EBV could make MS a thing of the past. Additionally, antiviral drugs could be developed to help high-risk patients with mono get through the illness faster and safer. Moderna has an EBV vaccine in early-stage trials.

via Insider|
#ebv#health#ms