Metformin: The Diabetes Pill That Could Slow Healthy Aging

Scientists review metformin, a first-line diabetes drug, and its potential to slow aging by activating AMPK, inhibiting the mTOR pathway, boosting autophagy, reducing oxidative stress, and possibly driving epigenetic and gut microbiome changes; while animal studies and some human data hint at slower biological aging, there is no conclusive evidence in non-diabetic people yet, and large randomized trials like the Targeting Aging with Metformin (TAME) are needed to confirm any longevity benefits.