Tag

Osteoarthritis

All articles tagged with #osteoarthritis

health6 days ago•5 min saved

Lacosamide Could Turn Osteoarthritis Treatment from Pain Relief to Cartilage Repair

Yale researchers repurposed lacosamide, an FDA-approved epilepsy drug, with a collagen II hydrogel delivered directly into the knee to simultaneously relieve pain and reverse cartilage damage in osteoarthritis. They show Nav1.7 drives both pain and cartilage breakdown in chondrocytes, and, at a precise low dose, lacosamide boosts cartilage-building proteins while triggering protective signals (HSP70 and midkine). The hydrogel enables weeks-long, localized drug release, outperforming daily oral dosing in preclinical tests, suggesting a faster path to human trials since the drug is already approved.

via SciTechDaily|

#cartilage-repair #health #hydrogel

health10 days ago•2 min saved

Silk-based scaffold regenerates knee cartilage in rat osteoarthritis model

Researchers developed a silk-protein–gelatine 3D scaffold chemically modified to block bone morphogenetic protein (BMP) signaling while enabling WNT/β-catenin pathways. Implanted into rat knee cartilage defects, the scaffold supported new cartilage formation expressing cartilage-specific collagen, with minimal inflammation and a tissue structure closely resembling natural cartilage, offering a potential approach for osteoarthritis treatment.

via Nature|

#bmp-inhibitor #cartilage-regeneration #health

science11 days ago•8 min saved

Blocking 15-PGDH May Rebuild Aging Cartilage and Ease Osteoarthritis

Stanford researchers identify the enzyme 15-PGDH as a key aging brake on cartilage repair. In mice, inhibiting 15-PGDH thickened worn cartilage and prevented arthritis after joint injury; human cartilage samples showed similar improvements, suggesting a potential new therapy for aging- and injury-related osteoarthritis. The work is part of broader ARPA-H/NITRO efforts with clinical trials planned, and does not rely on stem cells, instead reactivating existing cartilage cells.

via ScienceAlert|

#15-pgdh #aging #cartilage-regeneration

health17 days ago•2 min saved

Denosumab May Shield Joints in Osteoporosis Patients

Using Japanese claims data (2015–2024), new denosumab users had a 16% lower 3-year risk of developing osteoarthritis vs new oral bisphosphonate users (relative risk 0.84; 95% CI 0.73–0.89), especially for knee and hip OA. The benefit was not significant for those who switched from bisphosphonates to denosumab. Given the observational design and potential confounding, findings should be interpreted with caution and require clinically validated OA outcomes.

via Medscape|

#bisphosphonates #denosumab #health

health22 days ago•5 min saved

Breakthrough SHP protein could shield joints, slow osteoarthritis in early studies

South Korean researchers identify SHP (NR0B2) as a natural cartilage protector; in animal models, restoring SHP reduced joint damage and pain, and SHP gene delivery into damaged joints yielded lasting benefits, suggesting a potential approach to slow or prevent osteoarthritis—though human trials are needed and results are preclinical.

via Futura, le média qui explore le monde|

#cartilage #gene-therapy #health

health-news27 days ago•14 min saved

Carly Simon’s Early Parkinson’s Clues Began as Arthritis

Carly Simon revealed she has Parkinson’s disease, whose early signs began with arthritis in her knees and a hip that required joint replacements; after a Mayo Clinic evaluation she was diagnosed, highlighting research showing a link between arthritis (especially osteoarthritis) and Parkinson’s, and noting apathy as a common non-motor symptom; she’s started treatment and continues to work on music, including a new album.

via SheKnows|

#arthritis #carly-simon #health-news

health28 days ago•1 min saved

Pill-Based Knee Cartilage Repair Moves Closer to Reality

Stanford researchers report in mice that blocking a specific enzyme can restore cartilage thickness in aging knees, hinting that future pills or injections could repair osteoarthritis and reduce the need for knee or hip replacements. The approach reprograms cells to a younger state by inhibiting an enzyme; the same drug has completed phase 1 safety testing in humans and is heading to phase 2b trials for sarcopenia, signaling broader medical potential.

via thepost.co.nz|

#cartilage #clinical-trials #health

health1 month ago•5 min saved

Knee Cartilage Shaving: New Study Questions Benefit, Warns of Harm

A 10-year randomized study in the New England Journal of Medicine found that arthroscopic shaving of degenerative meniscal tears provides little to no benefit compared with sham surgery or physical therapy and may worsen pain and accelerate osteoarthritis, sometimes leading to more surgery such as knee replacement; the findings echo decades of evidence against routine knee arthroscopy and have helped reduce the procedure in many countries, though treatment varies and acute injuries may still warrant different care.

via KFF Health News|

#arthroscopy #health #knee

health1 month ago•5 min saved

One-Shot OA Reversal in Animals Sparks Hope for Human Trials

UC Boulder researchers report that a single, slow-release injection into damaged joints reversed osteoarthritis in animal models within four to eight weeks, with encouraging early tests on human cells; phase II safety/toxicity studies are planned ahead of potential human trials, though peer review is pending.

via ScienceAlert|

#animal-study #cartilage #health

health1 month ago•3 min saved

Regenerative Joint Therapies Reversing Osteoarthritis in Weeks, Aiming for Human Trials

Colorado researchers report two regenerative therapies that reversed osteoarthritis signs in animals within 4–8 weeks: an injectable drug-delivery system using a repurposed FDA-approved drug and a biomaterial that recruits body-progenitor cells to repair cartilage. Backed by ARPA-H’s NITRO program with up to $33.5 million, the team has moved from phase one to phase two, with potential human trials in about 18 months and plans for commercial development through Renovare Therapeutics.

via ScienceDaily|

#arpa-h #clinical-trials #health

science1 month ago•7 min saved

Low-Intensity Ultrasound Reprograms Immune Cells to Halt Joint Inflammation

Researchers at the University of Alabama in Huntsville report that continuous low‑intensity ultrasound can shift macrophages from a pro‑inflammatory M1 state to a reparative M2‑like state, lowering inflammation and promoting tissue repair after joint injury. This non‑invasive approach could help prevent post‑traumatic osteoarthritis, with findings based on a fibronectin fragment injury model and transcriptomic analysis; however, the work is laboratory‑stage and requires animal validation before clinical use.

via SciTechDaily|

#arthritis #inflammation #macrophages

health2 months ago•3 min saved

New Knee Therapy May Spare People from Replacement Surgery

Genicular artery embolization (GAE) is an outpatient, one- to two-hour procedure that reduces inflammation by blocking blood flow to abnormal knee vessels to ease chronic knee pain from osteoarthritis. It offers a potential middle-ground between conservative treatments and total knee replacement, with about 70% of patients experiencing substantial relief and pain scores halved or better; some report no pain. Recovery is typically quick, and ongoing CU Anschutz trials are exploring long-term outcomes and broader applications beyond the knee.

via ScienceDaily|

#genicular-artery-embolization #health #interventional-radiology

health2 months ago•36 min saved

One injection may regrow knee cartilage, reshaping osteoarthritis care

A patient with severely worn knee cartilage reportedly regrew cartilage after a single injection, offering a non-surgical alternative to knee replacement and signaling a potential shift in how osteoarthritis is treated.

via Yahoo|

#cartilage #health #injection

health2 months ago•42 min saved

New Non-Surgical Knee Therapy Delivers 12-Month Pain Relief

Genicular artery embolization (GAE), a minimally invasive procedure that injects resorbable gelatin microspheres to block abnormal knee vessels, aims to reduce inflammation and pain in osteoarthritis. In a real-world study of 194 participants (average age ~69), most experienced significant pain relief and improved function for at least 12 months, with 80% surpassing the minimum clinically important difference; about 23% needed a second GAE, and adverse events were mild and limited to 6.7% of participants. The treatment offers a potential middle option between injections and joint replacement.

via Good News Network|

#arthritis #health #knee

health2 months ago•7 min saved

Aging-protein blocker regenerates knee cartilage, signaling arthritis reversal

Blocking the aging-related enzyme 15-PGDH reprograms existing cartilage cells to regrow hyaline cartilage in aged mice and human knee tissue, prevents osteoarthritis after ACL-type injuries, and could be delivered by injection or an oral drug; the approach might reduce the need for joint replacements if proven in people, and related clinical trials for the inhibitor are already underway for other aging-related conditions; researchers note the regeneration comes from changing existing chondrocytes rather than stem cells, and there are patent/licensing ties involved.

via ScienceDaily|

#15-pgdh #cartilage-regeneration #gerozyme