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Gamma Delta T Cells

All articles tagged with #gamma delta t cells

health-and-science1 hour ago•1 min saved

Gamma-Delta T Cells Identified as Key to Defeating Small Cell Lung Cancer

Researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) have identified gamma-delta T cells as a potent immune defense against small cell lung cancer (SCLC), a disease with less than 7% five-year survival. Published in Cancer Cell, the study shows these cells can detect and destroy SCLC tumors that evade conventional immune responses. When combined with existing drugs tarlatamab and zoledronate, the efficacy of these immune cells increases significantly. The findings suggest new treatment strategies, including adoptive cell transfer, and indicate that gamma-delta T cell levels may predict patient response to immunotherapy.

via ScienceAlert|

#cancer-cell-journal #gamma-delta-t-cells #health-and-science

health-and-science2 hours ago•3 min saved

Gamma Delta T Cells Identified as Key to Defeating Small Cell Lung Cancer

Researchers at the Walter and Eliza Hall Institute (WEHI) have identified gamma delta T cells as a previously overlooked immune defense against small cell lung cancer (SCLC). Published in Cancer Cell, the study shows these cells can detect and destroy SCLC tumors that evade conventional immune surveillance. Laboratory tests using patient-derived mini-tumors demonstrated that combining gamma delta T cells with existing drugs, tarlatamab and zoledronate, significantly enhances cancer cell destruction. The findings suggest new strategies for improving immunotherapy outcomes in a disease where fewer than 7% of patients survive five years.

via Science Daily|

#cancer-cell #gamma-delta-t-cells #health-and-science

science6 months ago•6 min saved

Age Shifts Melanoma Behavior, Prompting Call for Age-Inclusive Cancer Research

New findings from Fox Chase Cancer Center show melanoma spread varies with age: lowest in young mice, highest in middle-aged, then dropping in old age, linked to gamma-delta T cells. The study suggests aging significantly alters cancer immunity and that most preclinical work in young animals may hinder translating therapies to older patients.

via SciTechDaily|

#aged-mice #aging #cancer

health3 years ago•3 min saved

Revolutionary Drug Eradicates Bowel Cancer, Offering Hope to Patients

Researchers at the Olivia Newton-John Cancer Research Institute have made a breakthrough in understanding the role of gamma delta T cells in preventing bowel cancer. These immune cells patrol and safeguard the large bowel, acting as frontline defenders against potential cancer threats. The study found that patients with more gamma delta T cells in their tumors had better outcomes and improved survival. The researchers also discovered that the microbiome in the large bowel affects the concentration of a molecule called TCF-1 on gamma delta T cells, which suppresses their ability to fight off bowel cancer. This research opens up new possibilities for developing targeted combination immunotherapies and strategies to lower bowel cancer risk.

via Medical Xpress|

#bowel-cancer #gamma-delta-t-cells #health

healthcare3 years ago•7 min saved

IN8bio's INB-100 Shows Promising Results in Leukemia Patients at EBMT 2023.

IN8bio has presented positive data from its Phase 1 trial of INB-100 in leukemia patients, showing that 100% of evaluable patients treated with INB-100 remained alive, progression-free, and in durable complete remission (CR) as of April 21, 2023. The latest data on immune reconstitution presented at the European Society for Blood and Marrow Transplantation (EBMT) showed significant allogeneic gamma-delta T cell expansion and persistence in patients through the first 180 days post-treatment. The study's updated safety data reported low-grade graft versus host disease (GvHD) in all patients treated, which was steroid-responsive, and had a more rapid onset at higher dose levels.

via Yahoo Finance|

#clinical-trial #complete-remission #gamma-delta-t-cells