All articles tagged with #gamma delta t cells
New findings from Fox Chase Cancer Center show melanoma spread varies with age: lowest in young mice, highest in middle-aged, then dropping in old age, linked to gamma-delta T cells. The study suggests aging significantly alters cancer immunity and that most preclinical work in young animals may hinder translating therapies to older patients.
Researchers at the Olivia Newton-John Cancer Research Institute have made a breakthrough in understanding the role of gamma delta T cells in preventing bowel cancer. These immune cells patrol and safeguard the large bowel, acting as frontline defenders against potential cancer threats. The study found that patients with more gamma delta T cells in their tumors had better outcomes and improved survival. The researchers also discovered that the microbiome in the large bowel affects the concentration of a molecule called TCF-1 on gamma delta T cells, which suppresses their ability to fight off bowel cancer. This research opens up new possibilities for developing targeted combination immunotherapies and strategies to lower bowel cancer risk.
IN8bio has presented positive data from its Phase 1 trial of INB-100 in leukemia patients, showing that 100% of evaluable patients treated with INB-100 remained alive, progression-free, and in durable complete remission (CR) as of April 21, 2023. The latest data on immune reconstitution presented at the European Society for Blood and Marrow Transplantation (EBMT) showed significant allogeneic gamma-delta T cell expansion and persistence in patients through the first 180 days post-treatment. The study's updated safety data reported low-grade graft versus host disease (GvHD) in all patients treated, which was steroid-responsive, and had a more rapid onset at higher dose levels.