Tag

Gut

All articles tagged with #gut

science5 days ago•7 min saved

Metformin’s Hidden Target: The Gut Takes Center Stage

New Northwestern University research in mice shows metformin mainly acts in the intestine, lowering blood sugar by reducing mitochondrial activity in gut cells and prompting them to burn more glucose, challenging the idea that the liver is the primary target. Published in Nature Metabolism, the study links berberine to a similar gut pathway and uses engineered mice to show that blocking mitochondrial complex I in the gut is central to metformin’s effect, with implications for gut-targeted diabetes therapies.

via SciTechDaily|

#diabetes #gut #intestine

health27 days ago•4 min saved

Gut Reset May Sustain Weight Loss After GLP-1 Treatments

A blinded, sham-controlled trial presented at DDW 2026 suggests duodenal mucosal resurfacing, an outpatient endoscopic gut-reset procedure, may help maintain weight loss after stopping GLP-1 drugs like ozempic/semaglutide. In 45 participants who had previously lost at least 15% body weight on tirzepatide, those who received the actual resurfacing regained about 7 pounds on average over six months, preserving over 80% of their initial weight loss, while controls (sham) regained far more. The procedure appeared safe with quick recovery; larger REMAIN-1 data are pending, with topline six-month results expected in late 2026, potentially offering a post-drug maintenance option if confirmed.

via SciTechDaily|

#duodenal-mucosal-resurfacing #glp-1 #gut

health1 month ago•1 min saved

Gut microbes: diversity helps immunity, but competition shapes balance

A diverse microbiome is linked to better health, but the relationship with immunity is not straightforward. New research suggests that while diversity matters, how bacterial groups compete or cooperate—affecting their growth—can influence immune balance. Claims of simple, dramatic microbiome changes are premature, so skepticism about bold health hacks is warranted.

via The Guardian|

#competition #diversity #gut

science1 month ago•6 min saved

Kimchi-Derived Probiotic May Help Gut Eliminate Nanoplastics

A kimchi-derived lactic acid bacterium, Leuconostoc mesenteroides CBA3656, binds nanoplastics in the gut and retains high adsorption under intestinal-like conditions, with mouse studies showing increased fecal excretion of nanoplastics, suggesting a probiotic approach to reducing plastic buildup in the gastrointestinal tract.

via SciTechDaily|

#gut #kimchi #lacticacidbacteria

health5 months ago•8 min saved

Expert-Backed Habits for Effective Liver and Gut Detoxification

True detoxification of the liver and gut is achieved through lifestyle habits like a balanced diet low in sugars and saturated fats, regular physical activity, microbiome support with fiber and fermented foods, managing metabolic conditions, and considering genomic insights, rather than trendy juice cleanses or extreme detox diets.

via Times of India|

#detox #gut #health

science6 months ago•2 min saved

Brain and Gut Rhythms Reveal Unexpected Connection

Scientists have discovered that rhythms in the brain and gut share similar physics, with coupled oscillation patterns helping to regulate blood flow and digestion, potentially offering insights into mental health and neurodegenerative diseases.

via ScienceAlert|

#biological-rhythms #brain #gut

science6 months ago•2 min saved

Research Reveals Unexpected Connection Between Gut and Brain Rhythms

Scientists at UC San Diego discovered that rhythmic muscle movements in the gut may explain how brain blood vessels coordinate their expansion and contraction, revealing a surprising link between gut and brain rhythms through synchronized oscillations.

via Medical Xpress|

#blood-vessels #brain #gut

health2 years ago•3 min saved

"Pineapple-Sized Immune System Discovered in Groundbreaking Study"

The human immune system consists of approximately 1.8 trillion cells, collectively weighing about 1.2 kilograms or 2.6 pounds, which is roughly the same weight as a pineapple. Researchers from the Weizmann Institute of Science in Israel conducted a comprehensive study to estimate the distribution and mass of immune cells in the human body. They found that the lymphatic system and bone marrow house the majority of immune cells, while the gastrointestinal tract contains only a small percentage. The study provides insights into the composition and organization of the immune system, shedding light on the largest reservoirs of immune cells and their implications for health and disease.

via ScienceAlert|

#gut #health #immune-cell-mass

health2 years ago•4 min saved

"Serotonin Depletion in Long Covid Patients: Unraveling the Mystery of 'Brain Fog'"

Scientists at the University of Pennsylvania have proposed a new explanation for some cases of long Covid, suggesting that depleted serotonin levels may be triggered by remnants of the virus lingering in the gut. The researchers found that serotonin reduction could explain memory problems and some neurological and cognitive symptoms of long Covid. This discovery could lead to new ways to diagnose and treat the condition, including medications that boost serotonin. The study also suggests that the serotonin pathway could unite many of the major theories of what causes long Covid, such as lingering viral remnants, inflammation, increased blood clotting, and dysfunction of the autonomic nervous system. Clinical trials of treatments, including fluoxetine (Prozac) and tryptophan, are underway to restore serotonin levels and improve symptoms.

via The New York Times|

#gut #health #long-covid

health2 years ago•6 min saved

"Gut Connection: Unveiling the Origins of Parkinson's Disease"

Researchers are exploring the "gut-first" hypothesis, which suggests that Parkinson's disease may originate in the gastrointestinal tract. Misfolded proteins, found excessively in the brains of Parkinson's patients, accumulate in the nerves of the gut wall and ascend to the brain, causing pathological changes. Evidence linking Parkinson's to the gut includes the prevalence of constipation as a symptom, the increased risk of Parkinson's in patients with inflammatory bowel disease, and the presence of misfolded proteins in the stomach wall of Parkinson's patients. Understanding the origins of Parkinson's could lead to early detection and treatment options.

via Yahoo News|

#early-detection #gut #health

health2 years ago•6 min saved

"Gut Connection: Unveiling the Origins of Parkinson's Disease"

via Yahoo! Voices|

#early-detection #gut #health

health2 years ago•6 min saved

Gut-to-Brain Progression: Parkinson's Disease Unveiled

Researchers are investigating the "gut-first" hypothesis, which suggests that Parkinson's disease may originate in the gastrointestinal tract. Abnormal proteins, known as misfolded proteins, accumulate in the nerves of the gut wall and then ascend to the brain, causing the pathological changes associated with Parkinson's. Gut problems, such as constipation and inflammatory bowel disease, have been identified as risk factors for the disease. Autopsy studies have confirmed the presence of misfolded proteins in the gut of Parkinson's patients, and experiments in mice have shown that these proteins can travel from the gut to the brain. Understanding the origins of Parkinson's could lead to early detection and treatment options.

via The Washington Post|

#gut #health #misfolded-proteins

health3 years ago•19 min saved

The Gut-Brain Connection: Microbiome and Pain.

Enterochromaffin cells in the gut have been found to play a key role in driving visceral pain and anxiety. These cells are sensitive to mechanical forces and release serotonin in response to them, which can activate pain-sensing neurons. Inhibiting these cells or their serotonin release could potentially be a target for treating conditions such as irritable bowel syndrome.

via Nature.com|

#anxiety #enterochromaffin-cells #gut