Tag

Molecular Self Assembly

All articles tagged with #molecular self assembly

science-and-technology2 months ago•27 min saved

New MOSAIC method enables high-throughput DNA synthesis via self-assembly

Researchers from Tsinghua University and collaborators have developed a new high-throughput gene synthesis method called Molecular Self-Assembly Induced Cloning (MOSAIC). The technique overcomes traditional bottlenecks in DNA synthesis by using the self-assembly of overlapping oligonucleotides in vitro, followed by cellular repair mechanisms in vivo. This approach allows for the parallel synthesis of over 1,000 distinct gene fragments in a single reaction, achieving near-zero misalignment. The method was validated by constructing massive variant libraries of the plastic-degrading enzyme PETase, yielding variants with higher potency than the current gold standard.

via Nature|

#biotechnology #dna-synthesis #molecular-self-assembly

science-and-technology2 years ago•66 min saved

"DNA-Based Pattern Recognition in Non-Equilibrium Self-Assembly Kinetics"

Researchers have demonstrated the use of molecular self-assembly for high-dimensional pattern recognition using DNA nanotechnology. By colocalizing molecules in different ways, they were able to control nucleation kinetics and achieve selective assembly of multiple target structures. This work shows that the phase diagram of self-assembling systems can naturally solve complex pattern recognition problems, similar to neural networks. The findings have implications for understanding biological systems and engineering autonomous molecular systems, and could potentially be applied to tasks such as image recognition using existing molecules.

via Nature.com|

#dna-nanotechnology #molecular-self-assembly #neural-computation

science3 years ago•10 min saved

Geometry Predicts Molecular Mosaics.

Scientists have developed a new way to predict how molecules might self-assemble into 2D sheets using the simple geometry of tessellation. By treating molecules as geometric tessellations, researchers used graph theory to describe molecular patterns, which allowed them to predict how molecules might self-assemble. The new mathematical framework assumes an infinite pattern, not a finite patch, but adapting the work to describe how finite patches grow into larger patterns could be a step toward genuine prediction.

via Quanta Magazine|

#geometry #materials-science #molecular-self-assembly