Tag

Notch Signaling

All articles tagged with #notch signaling

science10 days ago•17 min saved

Israeli study identifies rare cochlear cells with potential to reverse hearing loss

Tel Aviv University researchers report that inhibiting Notch signaling can trigger a rare subset of cochlear supporting cells (transdifferentiating Deiters’ cells) to become hair cells, offering a potential path to regenerate hearing. Using live imaging and single-cell multi-omics, the team shows this regenerative capacity exists in humans and could be leveraged with inner-ear injections, though it remains early basic research. Translation to patients will require overcoming regulatory, cost, and safety hurdles, but the work marks a significant step toward treatments that restore hearing rather than simply aiding it.

via The Jerusalem Post|

#cochlea #hair-cell-regeneration #hearing-loss

science1 month ago•78 min saved

Single-cell atlas links IBD risk to cell-type specific gene regulation

Researchers built IBDverse, the largest single-cell eQTL atlas for inflammatory bowel disease, mapping cis-eQTL effects across blood and gut tissues in about 400 individuals to link genetic risk to specific cell types. They find cell-type eQTLs are more distal, enhancer-rich, and far more likely to colocalize with IBD GWAS signals than bulk-tissue eQTLs, nominating effector genes such as MAML2 and ZMIZ1 in dendritic cells and MYC and RASGRP1 in colonocytes. Notch pathway regulators in dendritic cells and Wnt-driven epithelial renewal in colonocytes emerge as key mechanisms, tying regulatory variation to barrier dysfunction and inflammation. The study also highlights therapeutic angles—including PRKCB inhibitors and targets like ITGA4/JAK2—and provides a framework for interpreting GWAS loci via cell-type–resolved eQTL mapping in complex diseases.

via Nature|

#eqtl #gwas #ibd

science5 months ago•5 min saved

Notch Timing Unlocks Lab-Grown Helper and Killer T Cells for Off-the-Shelf Immunotherapy

UBC researchers show that precisely tuning the duration and intensity of Notch signaling in stem cells can reliably steer them to become helper or killer T cells, enabling scalable, off-the-shelf immunotherapies for cancer and other diseases. This overcomes a long-standing bottleneck by producing both T cell types from renewable sources, potentially reducing manufacturing costs and time.

via Indian Defence Review|

#immunotherapy #notch-signaling #off-the-shelf