Tag

Personalized Vaccine

All articles tagged with #personalized vaccine

health29 days ago•4 min saved

World-first personalized lung cancer vaccine arrives in Merseyside trial

A 68-year-old Merseyside woman, Chris Jones, has become the first in the world to receive a personalized vaccine for advanced non-small cell lung cancer in an early-stage trial at Clatterbridge Cancer Centre. The vaccine uses DNA derived from her tumour to create a patient-specific immunotherapy, delivered alongside her standard treatment in a seven-dose, 24-week regimen. Researchers hope it boosts the immune response and overcomes resistance to current immunotherapy, with results assessed after six weeks; only 10 participants are taking part in this world-first study led by Professors Ottensmeier and Savelyeva.

via BBC|

#clinical-trial #health #immunotherapy

medical-research3 months ago•15 min saved

Tailored DNA vaccine sparks immune response against glioblastoma in early trial

A phase 1 trial at Siteman Cancer Center shows a personalized neoantigen DNA vaccine (GNOS-PV01) for glioblastoma is safe and elicits robust immune responses; among nine patients, about two-thirds had no progression at six months and two-thirds were alive at one year, including a long-term recurrence-free survivor, indicating potential benefit and the need for larger trials.

via WashU Medicine|

#dna-vaccine #glioblastoma #immunotherapy

science4 months ago•7 min saved

Personalized mRNA Vaccine Sparks Long-Term Survival in Pancreatic Cancer

At the AACR meeting, researchers report a phase 1 trial of a patient-specific mRNA vaccine for pancreatic cancer, made from each patient's tumor material after surgery and used with immunotherapy and chemotherapy. Eight patients showed immune responses, and seven of these responders were alive up to six years post-surgery, with about 90% of responders remaining alive at follow-up. While promising, the findings come from a small early trial, and a global phase 2 study is now underway to assess broader efficacy.

via ScienceAlert|

#immunotherapy #mrna-vaccine #pancreatic-cancer

health4 months ago•14 min saved

Personalized mRNA Cancer Vaccines Show Promise Amid Turbulence

A small Memorial Sloan Kettering study finds a patient-specific mRNA vaccine for pancreatic cancer can provoke strong immune responses and deliver long-term survivors, despite a turbulent year of funding and public skepticism around mRNA. Eight of 16 patients had a meaningful immune response and seven are alive six years after the trial; larger multisite trials and industry backing are advancing the approach, which also includes non-personalized, off-the-shelf vaccines aiming to trigger broader anti-tumor immunity.

via WRAL|

#cancer-vaccines #health #immunotherapy

health4 months ago•15 min saved

mRNA Cancer Vaccines Show Promising, Durable Early Results

After a turbulent year for funding and public trust, early-stage trials of mRNA cancer vaccines—including a personalized vaccine for pancreatic cancer—are showing strong immune responses and potential long-term benefit, with larger multisite trials and renewed NIH/NCI support underway, though funding and skepticism remain challenges.

via CNN|

#cancer-immunotherapy #clinical-trials #health