Tag

Preclinical

All articles tagged with #preclinical

health-and-medicine6 hours ago•5 min saved

Novel human antibody stalls spread of aggressive prostate cancer in preclinical study

Researchers at Umeå University and collaborators developed a fully human antibody that stopped growth and metastatic spread of an aggressive prostate cancer in preclinical tests, via a newly identified mechanism that may carry a lower risk of side effects. While promising, the therapy requires further safety studies and regulatory approval before clinical use, and researchers plan to explore its potential against other solid tumors.

via ScienceDaily|

#cancer-therapy #health-and-medicine #metastasis

science3 months ago•4 min saved

Epigenetic Alzheimer's Drug FLAV-27 Reverses Memory Decline in Mice

Researchers report FLAV-27, a G9a/EHMT2 inhibitor, epigenetically reprograms neuronal gene expression to combat Alzheimer's pathology; in cell cultures, nematodes, and mice it reduced disease features and restored memory and synaptic function, suggesting a broader upstream approach beyond amyloid and tau. The compound has not yet been tested in humans and would require extensive safety and regulatory steps before trials.

via ScienceAlert|

#alzheimers #ehmt2g9a #epigenetics

health-and-medicine4 months ago•24 min saved

Epigenetic drug reverses Alzheimer’s memory loss in mice, UB study shows

University of Barcelona researchers report that FLAV-27, a first-in-class SAM-competitive G9a inhibitor, reverses cognitive deficits in multiple Alzheimer’s disease mouse models by reprogramming neuronal gene activity, a mechanism distinct from beta-amyloid–targeting drugs; the compound is currently in preclinical stages and could represent a disease-modifying approach pending human safety data.

via Ground News|

#alzheimers-disease #epigenetics #flav-27

health5 months ago•7 min saved

NCI Explores Ivermectin as Cancer Treatment, Prompting Cautious Scrutiny

The National Cancer Institute is conducting a preclinical study of ivermectin as a potential cancer therapy, with results expected in months, a move that has drawn opposition from some scientists who say there is no solid evidence and warn about misinforming patients, even as officials and influencers promote the idea.

via statnews.com|

#cancer #health #ivermectin

business-finance2 years ago•0 min saved

"Metagenomi Sets IPO Range, Eyes $87M for Gene Editing Biotech"

Metagenomi, a gene editing company, has set a price range for its proposed initial public offering, expecting to raise about $87 million if it prices at $16 per share. The California startup plans to go public later this week by selling 6.25 million shares, with the potential for increased proceeds if the company upsizes before landing on Nasdaq.

via Endpoints News|

#biotech #business-finance #california