Tag

Metastasis

All articles tagged with #metastasis

entertainment14 days ago•14 min saved

Lucy Davis Reveals Stage IV Breast Cancer Has Metastasized, Says She’s At Peace

Lucy Davis, the UK The Office star, revealed on Instagram that a stage-four breast cancer diagnosis from a year and a half ago has metastasized to her spine, right hip, and ribs, making the disease incurable and ending chemotherapy. She says she's at peace and intends to live life to the fullest while continuing acting and animal-rights activism, despite pain and wheelchair use, and she urges others to seek medical checks for unusual symptoms.

via Rolling Stone|

#breast-cancer #cancer-diagnosis #entertainment

science16 days ago•6 min saved

Sugary Signal: Fructose From Senescent Cancer Cells May Drive Ovarian Tumor Spread

A Nature Aging study shows fructose secreted by chemotherapy‑induced senescent ovarian cancer cells acts as a signaling molecule that reduces cell adhesion and promotes detachment and metastasis in cell cultures and mice; altering fructose metabolism blocked movement, and high-fructose intake worsened spread in animals, suggesting dietary fructose restriction and senolytic therapies could improve treatment outcomes—though findings are preclinical and not yet applicable to humans.

via ScienceAlert|

#cancer #fructose #metastasis

science19 days ago•8 min saved

Viagra May Slow Cancer Spread by Trapping Cholesterol, Study Finds

Sildenafil (Viagra) appears to disrupt cholesterol trafficking in cancer cells, limiting their ability to spread in mouse models of breast, lung, and colon cancer, while a retrospective analysis of health records from over 40,000 male cancer patients linked combined sildenafil and statin use to about a 31% lower five-year mortality versus neither drug. The results are observational and require clinical trials to confirm causality.

via StudyFinds|

#cancer #cholesterol #metastasis

health20 days ago•6 min saved

Sildenafil may curb cancer spread, study suggests

A Weizmann Institute study suggests sildenafil (Viagra’s active ingredient) may slow cancer metastasis by disrupting how cancer cells use cholesterol, potentially reducing the spread to distant tumors. The work combines human data, cell and mouse experiments, and suggests that pairing PDE5 inhibitors with statins could help limit tumor spread, but the human evidence is observational and does not prove causation; more research is needed before clinical application.

via Fox News|

#cancer #cholesterol #health

health20 days ago•8 min saved

Fructose as a Hidden Signal May Drive Ovarian Cancer Spread

Researchers at The Wistar Institute found that fructose released by treatment-surviving ovarian cancer cells acts as a signal that weakens cell–cell adhesion and promotes detachment and spread. The effect can occur even without chemotherapy, and higher dietary fructose may influence tumor behavior, with cholesterol-lowering statins also weakening cancer cell adhesion. The study, published in Nature Aging, raises the possibility that this mechanism could occur in other torso-spreading cancers, though clinical studies are needed.

via SciTechDaily|

#chemotherapy #fructose #health

science20 days ago•102 min saved

ZFP36L2 serves as a stress-switch linking regeneration and metastasis in colorectal cancer

A study identifies the RNA-binding protein ZFP36L2 as a stress-responsive switch that binds AU-rich 3′ UTRs in stress-related mRNAs, drives condensate formation and targeted degradation to terminate the stress response, and enables dedifferentiation into LGR5+ intestinal stem cells necessary for regeneration and canonical metastasis. In ZFP36L2-deficient colorectal cancer, canonical metastasis seeding is impaired but non-canonical, heterogeneous cell states emerge, linking ZFP36L2 to cancer plasticity and patient outcomes.

via Nature|

#cellular-plasticity #colorectal-cancer #metastasis

health21 days ago•4 min saved

Viagra may slow cancer spread by blocking cholesterol transport, study suggests

New research suggests sildenafil (Viagra) may slow cancer metastasis by disrupting cholesterol transport inside cancer cells, effectively starving tumors of a key resource. The findings—spanning mouse models, patient-derived cancer cells, and large health records—also point to better survival when sildenafil is used with statins, highlighting the influence of a patient’s metabolic state on cancer progression.

via New York Post|

#cancer #cholesterol #health

health-and-medicine21 days ago•8 min saved

Sweet Signal: Fructose Secreted by Chemo-Treated Cells May Drive Ovarian Cancer Spread

Researchers at The Wistar Institute report that fructose released by chemotherapy-surviving ovarian cancer cells acts as a signal to neighboring tumor cells, promoting detachment and metastatic spread. In preclinical tests, high dietary fructose could enhance cancer spread by lowering cholesterol production in nearby cells, weakening cell adhesion; the finding also suggests interactions with cholesterol-lowering drugs (statins). While intriguing, these effects have not been tested in patients, and researchers caution against changing medications yet. More studies are planned to see if this pathway affects other cancers and whether diet or statin use could influence outcomes.

via ScienceDaily|

#chemotherapy #cholesterol #fructose

health24 days ago•7 min saved

Fructose Could Help Cancer Cells Escape and Spread, Study Finds

A new study suggests fructose, a common sugar in fizzy drinks, can act as a signal for surviving cancer cells after chemotherapy, helping them spread by suppressing cholesterol in neighboring cells and reducing adhesion; higher fructose intake may promote cancer spread even without chemo.

via The Independent|

#cancer #chemotherapy #fructose

health1 month ago•9 min saved

Viagra Ingredient May Halt Cancer Spread by Trapping Cholesterol

A study led by the Weizmann Institute of Science suggests sildenafil (Viagra) may prevent cancer cells from spreading by causing cholesterol to accumulate in recycling compartments, depriving tumors of cholesterol needed for invasion; while promising, clinical trials are needed to confirm it can reduce metastasis in patients.

via ZME Science|

#cancer #cholesterol #health

health-and-medicine1 month ago•5 min saved

Novel human antibody stalls spread of aggressive prostate cancer in preclinical study

Researchers at Umeå University and collaborators developed a fully human antibody that stopped growth and metastatic spread of an aggressive prostate cancer in preclinical tests, via a newly identified mechanism that may carry a lower risk of side effects. While promising, the therapy requires further safety studies and regulatory approval before clinical use, and researchers plan to explore its potential against other solid tumors.

via ScienceDaily|

#cancer-therapy #health-and-medicine #metastasis

science1 month ago•6 min saved

KRAS-targeting PCAIs halt pancreatic cancer cell migration in lab study

Researchers at Florida A&M University tested polyisoprenylated cysteinyl amide inhibitors (PCAIs) against pancreatic cancer cells to disrupt mutant KRAS signaling. The leading compound NSL-YHJ-2-27 blocked more than 90% of cell migration at low concentrations, altered gene and protein markers related to movement, disrupted actin filaments, and dismantled 3D mini-tumor models; however, these findings are limited to lab studies and require animal testing and safety assessment before any human trials.

via ScienceAlert|

#in-vitro #kras #metastasis

health1 month ago•9 min saved

GLP-1 Drugs May Slow Metastasis in Obesity-Related Cancers, Early ASCO Data

Real-world TriNetX data presented at ASCO 2026 show GLP-1 receptor agonists used after cancer diagnosis linked to reduced metastatic progression across several obesity-related cancers, notably NSCLC, breast, colorectal, and hepatocellular carcinoma; in NSCLC, progression to stage IV was 10.0% with GLP-1 RAs vs 22.3% with DPP-4 inhibitors (HR 0.50). GLP-1 receptor expression also correlated with better overall survival, suggesting a potential class effect and the need for further study.

via The ASCO Post|

#breast-cancer #glp-1-receptor-agonists #health

health-and-medicine1 month ago•6 min saved

PCAIs push pancreatic cancer cells to self-destruct by overactivating key signaling pathways

Researchers found experimental PCAIs kill pancreatic cancer cells and block their spread by hyperactivating MAPK and PI3K/AKT pathways, triggering ROS buildup and apoptosis; the leading compound NSL-YHJ-2-27 cut migration by over 90% at 1 µM and disrupted tumor spheroids, suggesting potential against several KRAS mutations, though further research is needed.

via ScienceDaily|

#apoptosis #health-and-medicine #kras-mutations

health2 months ago•5 min saved

Tapeworms Masquerade as Brain Cancer in Spain

A 60-year-old man in Spain with persistent headaches and multiple brain lesions was initially suspected to have metastatic cancer, but MRI revealed encapsulated tapeworm larvae (neurocysticercosis) caused by Taenia solium; no cancer was found after extensive testing, and he recovered after antiparasitic treatment, underscoring that NCC can mimic metastatic disease even without travel history.

via Ars Technica|

#health #metastasis #misdiagnosis