Tag

Metastasis

All articles tagged with #metastasis

science9 days ago•6 min saved

KRAS-targeting PCAIs halt pancreatic cancer cell migration in lab study

Researchers at Florida A&M University tested polyisoprenylated cysteinyl amide inhibitors (PCAIs) against pancreatic cancer cells to disrupt mutant KRAS signaling. The leading compound NSL-YHJ-2-27 blocked more than 90% of cell migration at low concentrations, altered gene and protein markers related to movement, disrupted actin filaments, and dismantled 3D mini-tumor models; however, these findings are limited to lab studies and require animal testing and safety assessment before any human trials.

via ScienceAlert|

#in-vitro #kras #metastasis

health10 days ago•9 min saved

GLP-1 Drugs May Slow Metastasis in Obesity-Related Cancers, Early ASCO Data

Real-world TriNetX data presented at ASCO 2026 show GLP-1 receptor agonists used after cancer diagnosis linked to reduced metastatic progression across several obesity-related cancers, notably NSCLC, breast, colorectal, and hepatocellular carcinoma; in NSCLC, progression to stage IV was 10.0% with GLP-1 RAs vs 22.3% with DPP-4 inhibitors (HR 0.50). GLP-1 receptor expression also correlated with better overall survival, suggesting a potential class effect and the need for further study.

via The ASCO Post|

#breast-cancer #glp-1-receptor-agonists #health

health-and-medicine11 days ago•6 min saved

PCAIs push pancreatic cancer cells to self-destruct by overactivating key signaling pathways

Researchers found experimental PCAIs kill pancreatic cancer cells and block their spread by hyperactivating MAPK and PI3K/AKT pathways, triggering ROS buildup and apoptosis; the leading compound NSL-YHJ-2-27 cut migration by over 90% at 1 µM and disrupted tumor spheroids, suggesting potential against several KRAS mutations, though further research is needed.

via ScienceDaily|

#apoptosis #health-and-medicine #kras-mutations

health15 days ago•5 min saved

Tapeworms Masquerade as Brain Cancer in Spain

A 60-year-old man in Spain with persistent headaches and multiple brain lesions was initially suspected to have metastatic cancer, but MRI revealed encapsulated tapeworm larvae (neurocysticercosis) caused by Taenia solium; no cancer was found after extensive testing, and he recovered after antiparasitic treatment, underscoring that NCC can mimic metastatic disease even without travel history.

via Ars Technica|

#health #metastasis #misdiagnosis

science1 month ago•39 min saved

GLP-1 drugs show potential to slow cancer spread, study suggests

A new study suggests GLP-1 receptor agonists, drugs commonly used to treat diabetes and obesity, may reduce the risk of cancer spread in certain cancers, a finding that could point to drug repurposing but requires further research to confirm which cancers might benefit and to establish clinical relevance.

via Yahoo|

#cancer #diabetes-treatment #drug-repurposing

health1 month ago•10 min saved

GLP-1 Diabetes Drugs Hint at Slowing Cancer Spread, Early Observational Findings

New findings from the Cleveland Clinic, presented at the ASCO meeting, suggest GLP-1 medications may be linked to reduced metastatic progression in several obesity-related cancers (notably non-small cell lung, breast, colorectal, and liver cancers) when compared with DPP-4 inhibitors. The study is observational and not peer‑reviewed, and it does not prove GLP-1s kill cancer cells or should be used for cancer prevention. Researchers caution that more rigorous, randomized trials are needed before changing cancer treatment guidelines.

via HuffPost|

#asco #cancer-progression #glp-1

science4 months ago•6 min saved

Cherry compounds slow aggressive breast cancer in mice, study finds

Texas A&M researchers report that anthocyanins in dark sweet cherries slowed tumor growth and reduced metastasis in a mouse model of triple-negative breast cancer. In a four-group setup (cherry extract before tumors, chemotherapy after tumors, both, or neither), mice given cherry extract showed slower tumor growth and maintained weight, with the strongest effects when exposed before tumor implantation. The findings are preclinical and require human studies to determine relevance to people with this aggressive breast cancer subtype.

via Fox News|

#anthocyanins #dark-sweet-cherries #metastasis

science5 months ago•7 min saved

Engineered Liposomes Map Cancer Spread and Hint at Stopping It

Researchers are investigating how cancer uses extracellular vesicles to colonize new organs and are creating artificial liposomes that mimic these vesicles to observe uptake by cancer cells in real time, with the goal of delivering targeted therapies and ultimately blocking metastasis while improving drug delivery.

via ScienceAlert|

#drug-delivery #extracellular-vesicles #liposomes

science5 months ago•5 min saved

Cancer hijacks immune cell mitochondria to boost spread and dodge defenses

In mice, cancer cells acquire mitochondria from immune cells, weakening those cells and activating a type I interferon program in the cancer cells that promotes lymph‑node invasion. Blocking this pathway reduces spread, and the effect occurs even when the stolen mitochondria can’t produce ATP, indicating energy production isn’t required for this mechanism.

via Nature|

#cancer #immunology #lymph-nodes

health6 months ago•8 min saved

Understanding and Preventing Late Cancer Recurrence

Many cancers can recur years after initial treatment due to dormant tumour cells that evade therapy and immune detection, with ongoing research aiming to understand and target these cells to prevent relapse.

via Nature|

#cancer-recurrence #cancer-research #dormant-tumour-cells

health-and-medicine6 months ago•49 min saved

p53 Loss Promotes Breast Cancer Brain Metastasis via SCD1 and Fatty Acid Metabolism

The article discusses how inactivation of p53 promotes breast cancer metastasis to the brain by upregulating SCD1 and enhancing fatty acid metabolism, highlighting potential molecular targets for therapy.

via Nature|

#breast-cancer #fatty-acid-metabolism #health-and-medicine

health7 months ago•5 min saved

Scientists Near Breakthrough in Universal Cancer Vaccine

Scientists at UMass Amherst have developed a nanoparticle-based vaccine that successfully prevents multiple aggressive cancers in mice, including melanoma, pancreatic, and breast cancers, by activating strong immune memory and targeting cancer-specific antigens, with potential for broad application in cancer prevention and treatment.

via SciTechDaily|

#cancer-vaccine #health #immunotherapy

health8 months ago•3 min saved

Biden completes radiation therapy for prostate cancer

Joe Biden has completed a series of radiation treatments for an aggressive, metastatic prostate cancer, with ongoing assessments needed to determine if further treatment is necessary. The former president's health updates have raised public concern, but he appears to be making progress in his recovery.

via CBS News|

#cancer-treatment #health #joe-biden

health8 months ago•3 min saved

Experimental 'Super-Vaccine' Shows Promise in Preventing Multiple Cancers

Researchers at the University of Massachusetts Amherst have developed a nanoparticle-based 'super-vaccine' that has shown promising results in preventing and stopping the spread of breast, pancreatic, and melanoma cancers in mice, with potential for future human applications.

via IFLScience|

#cancer #health #immunotherapy

health9 months ago•4 min saved

Nanoparticle 'Super Vaccine' Prevents and Stops Cancer Spread in Mice

Researchers at UMass Amherst developed a nanoparticle-based 'super vaccine' that successfully prevents and fights aggressive cancers like melanoma, pancreatic, and breast cancer in mice, showing high efficacy in preventing tumor growth and metastasis, with potential for human application.

via ScienceDaily|

#cancer #health #immunotherapy