All articles tagged with #metastasis
A new study suggests GLP-1 receptor agonists, drugs commonly used to treat diabetes and obesity, may reduce the risk of cancer spread in certain cancers, a finding that could point to drug repurposing but requires further research to confirm which cancers might benefit and to establish clinical relevance.
New findings from the Cleveland Clinic, presented at the ASCO meeting, suggest GLP-1 medications may be linked to reduced metastatic progression in several obesity-related cancers (notably non-small cell lung, breast, colorectal, and liver cancers) when compared with DPP-4 inhibitors. The study is observational and not peer‑reviewed, and it does not prove GLP-1s kill cancer cells or should be used for cancer prevention. Researchers caution that more rigorous, randomized trials are needed before changing cancer treatment guidelines.
Texas A&M researchers report that anthocyanins in dark sweet cherries slowed tumor growth and reduced metastasis in a mouse model of triple-negative breast cancer. In a four-group setup (cherry extract before tumors, chemotherapy after tumors, both, or neither), mice given cherry extract showed slower tumor growth and maintained weight, with the strongest effects when exposed before tumor implantation. The findings are preclinical and require human studies to determine relevance to people with this aggressive breast cancer subtype.
Researchers are investigating how cancer uses extracellular vesicles to colonize new organs and are creating artificial liposomes that mimic these vesicles to observe uptake by cancer cells in real time, with the goal of delivering targeted therapies and ultimately blocking metastasis while improving drug delivery.
In mice, cancer cells acquire mitochondria from immune cells, weakening those cells and activating a type I interferon program in the cancer cells that promotes lymph‑node invasion. Blocking this pathway reduces spread, and the effect occurs even when the stolen mitochondria can’t produce ATP, indicating energy production isn’t required for this mechanism.
Many cancers can recur years after initial treatment due to dormant tumour cells that evade therapy and immune detection, with ongoing research aiming to understand and target these cells to prevent relapse.
The article discusses how inactivation of p53 promotes breast cancer metastasis to the brain by upregulating SCD1 and enhancing fatty acid metabolism, highlighting potential molecular targets for therapy.
Scientists at UMass Amherst have developed a nanoparticle-based vaccine that successfully prevents multiple aggressive cancers in mice, including melanoma, pancreatic, and breast cancers, by activating strong immune memory and targeting cancer-specific antigens, with potential for broad application in cancer prevention and treatment.
Joe Biden has completed a series of radiation treatments for an aggressive, metastatic prostate cancer, with ongoing assessments needed to determine if further treatment is necessary. The former president's health updates have raised public concern, but he appears to be making progress in his recovery.
Researchers at the University of Massachusetts Amherst have developed a nanoparticle-based 'super-vaccine' that has shown promising results in preventing and stopping the spread of breast, pancreatic, and melanoma cancers in mice, with potential for future human applications.
Researchers at UMass Amherst developed a nanoparticle-based 'super vaccine' that successfully prevents and fights aggressive cancers like melanoma, pancreatic, and breast cancer in mice, showing high efficacy in preventing tumor growth and metastasis, with potential for human application.
A study from MD Anderson Cancer Center found that the glucose-fructose mix in sugary drinks promotes metastasis in advanced colorectal cancer by activating the SORD enzyme, suggesting that reducing sugary drink intake and targeting SORD could help slow disease progression.
Consumption of sugary drinks containing glucose and fructose promotes colorectal cancer metastasis via activation of the enzyme SORD, which increases the NAD+/NADH ratio and activates the mevalonate pathway, thereby enhancing cancer cell motility and spread.
Scientists at Rockefeller University discovered that mitochondrial glutathione, transported by SLC25A39, plays a crucial role in enabling breast cancer cells to metastasize, not by acting as an antioxidant but by activating stress response pathways, with potential implications for future cancer therapies.
Research reveals that mitochondrial glutathione and its transporter SLC25A39 play a crucial role in breast cancer metastasis by activating stress response pathways, with potential implications for targeted therapies to prevent cancer spread.