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Tofa

All articles tagged with #tofa

health1 month ago•4 min saved

TOFA boosts fat burning without appetite loss, preserves muscle in obese mice

UC Berkeley researchers identify oral TOFA as a weight-loss candidate that increases energy expenditure in obese mice (≈18% weight loss) without reducing appetite or lean mass, by blocking lipid production and activating fat-burning genes. It also reduced liver fat/inflammation in mouse models and showed enhanced effects when combined with drugs like semaglutide or tirzepatide, but human safety, dosing, and long-term effects remain unknown; results are limited to mice to date.

via AOL.com|

#energy-expenditure #health #muscle-preservation

health1 month ago•7 min saved

Oral TOFA boosts fat burning and may preserve muscle in weight loss

Researchers at UC Berkeley identified TOFA, an oral compound that reduced body weight in obese mice by about 18% by increasing energy expenditure rather than suppressing appetite, and it preserved lean mass; when paired with GLP-1 drugs such as semaglutide or tirzepatide, it produced greater weight loss and improved metabolic markers; TOFA also showed liver benefits in mouse models of fatty liver disease, without raising triglycerides. The effects in humans are unknown, the study involved only male mice, and questions remain about dosing, safety, and long-term risks before any human use.

via foxnews.com|

#energy-expenditure #health #mice-study

health1 month ago•4 min saved

Metabolism-boosting compound may spark fat burn without dulling appetite

In a mouse study, TOFA increased energy expenditure by about 18% and promoted weight loss by boosting metabolism without reducing lean muscle or appetite; it blocks liver fat production, lowers triglycerides, and improves insulin sensitivity and fatty liver markers. When used with GLP-1 drugs, TOFA showed greater improvements across weight, glucose control, and lipids, though human safety and efficacy remain untested.

via New York Post|

#glp-1 #health #metabolism

health1 month ago•48 min saved

New obesity drug TOFA may burn fat without muscle loss in mice

Researchers at UC Berkeley identified TOFA, an experimental compound that appears to boost metabolism and increase fat burning in mice without reducing food intake, potentially avoiding lean-muscle loss seen with GLP-1 drugs. In animal studies, TOFA-treated mice burned more energy, and when combined with GLP-1 medications like semaglutide or tirzepatide, the weight-loss effect was greater than with either treatment alone. Human trials have not yet begun.

via Yahoo|

#glp-1 #health #metabolism

health1 month ago•9 min saved

Oral TOFA Triggers Fat Burn, Preserves Muscle, and Boosts Obesity Drugs in Mice

A preclinical study in obese mice shows the oral compound TOFA reduces body weight by about 18% without changing food intake or causing muscle loss, by both limiting fat production and increasing cellular energy expenditure (about 18%). TOFA also improves fatty liver disease and blood lipid markers. When combined with obesity drugs like semaglutide (Ozempic/Wegovy) or tirzepatide (Mounjaro/Zepbound), the cotreatments outperform single drugs and maintain weight loss longer after treatment ends, suggesting a complementary mechanism that could enhance current therapies. Human safety and dosing remain unknown, and the work is limited to animal models.

via StudyFinds|

#fatty-liver-disease #health #metabolism

science1 month ago•6 min saved

Experimental fat-burner TOFA triggers fat loss by boosting energy use in obese mice

UC Berkeley researchers report that the experimental compound TOFA (5-tetradecyloxy-2-furoic acid) increased whole-body energy expenditure by up to 18% and produced about 18% weight loss in obese male mice on a high-fat diet over four weeks, mainly from fat while preserving lean mass; food intake and activity were unchanged. TOFA appears to slow fat creation and boost fat burning, though exact cellular mechanisms are unclear. Lower-dose TOFA combined with GLP-1 drugs semaglutide or tirzepatide yielded greater weight loss than either alone, suggesting potential synergy. The work is in mice, TOFA has not been tested in humans, and safety/dosing are unknown; further toxicology and animal studies precede any human trials. Authors are co-founders of ReRx Therapeutics.

via ScienceAlert|

#energy-expenditure #fat-metabolism #mice

health1 month ago•36 min saved

TOFA signals fat-burning in mice without muscle loss, hinting at a GLP-1 combo therapy

A new experimental compound called TOFA increased energy expenditure by up to 18% in mice without reducing appetite or increasing activity, and it also blocks two enzymes involved in fat and cholesterol production. Unlike GLP-1 drugs (Ozempic/Wegovy/Zepbound), which can cause lean muscle loss during rapid weight loss, TOFA could enable fat loss while preserving muscle and might be used alongside GLP-1 therapies. The findings are early and limited to animals, with human trials not yet underway.

via Currently.com|

#glp-1 #health #muscle-mass

health-and-medicine1 month ago•7 min saved

Old ACC inhibitor TOFA drives fat burning while preserving muscle in mice

UC Berkeley researchers report that TOFA, an old ACC inhibitor, lowers lipid production and activates fat-burning energy pathways in obese mice, increasing energy use by up to 18% and reducing fat while preserving lean mass; it also improves insulin sensitivity and triglycerides and works additively with GLP-1 obesity drugs, though safety in humans remains untested and researchers are pursuing clinical development.

via Science Daily|

#energy-expenditure #glp-1 #health-and-medicine