Tag

Transcriptomics

All articles tagged with #transcriptomics

science1 month ago•4 min saved

Postmenopausal Ovaries Shift to Immune-Driven Role, Study Finds

New research shows that ovaries don’t simply stop after menopause; in mice, aging ovaries transition from reproductive function to an immune-dominant profile with increased immune cell activity, suggesting post-reproductive ovaries may influence aging and health. Human tissue data align with this immune shift, challenging the idea of inert postmenopausal ovaries and implying potential implications for healthcare and people who have had ovaries removed.

via ScienceAlert|

#aging #immune-system #menopause

technology2 months ago•11 min saved

AI-powered virtual cells set to forecast how biology reacts to perturbations

Researchers are building ‘virtual cells’—AI- and mechanistic-models trained on large transcriptomic and other omics datasets—to simulate cellular states and predict how cells respond to different perturbations, with the goal of speeding hypothesis generation and identifying therapeutic avenues. While foundations models and data platforms (like scBaseCount, Pisces, X-Atlas, and State) show promise for predicting perturbation effects and immune-cell behavior, experts caution that current models mainly capture static states, struggle with dynamic evolution and tissue-scale mapping, and remain limited by noisy data and a need for causal, diverse training data to achieve robust, translatable predictions.

via Nature|

#foundation-models #perturbation-data #systems-biology

science3 months ago•12 min saved

RNA clocks forecast aging and mortality across mammals

Nature News & Views describes Tyshkovskiy et al.’s cross-tissue, cross-species transcriptomic model that estimates chronological age and predicts mortality from RNA data across four mammalian species, revealing universal ageing hallmarks and potentially accelerating anti-ageing interventions.

via Nature|

#aging #biomarkers #cross-species

science1 year ago•3 min saved

Scientists Reveal Immunoglobulins' Dual Role in Aging

Scientists from the Chinese Academy of Sciences and BGI Research have discovered that immunoglobulins play a dual role in the aging process, potentially reshaping our understanding of aging. By creating high-precision spatial transcriptomic maps of nine organs in mice, the study identified immunoglobulin G (IgG) as a key driver of aging, which accumulates in tissues and induces aging effects. The research suggests IgG levels could serve as biomarkers for aging and introduces an intervention using antisense oligonucleotides to reduce IgG and delay aging.

via Phys.org|

#aging #biomarkers #gerontology

science-and-technology2 years ago•147 min saved

Mapping the Mouse Brain: Unveiling the Secrets of Human DNA and Cell Types

Scientists have created a comprehensive and high-resolution transcriptomic and spatial atlas of cell types in the entire adult mouse brain. Using single-cell RNA sequencing and spatial transcriptomics analysis, they identified 34 classes, 338 subclasses, 1,201 supertypes, and 5,322 clusters or types of cells in the mouse brain. The atlas provides detailed information about the molecular and anatomical properties of different cell types, allowing researchers to study the relationships between cell types and their spatial distribution in the brain. The data is available through the Allen Brain Cell Atlas, an online platform that enables researchers to explore and analyze the cell types in the mouse brain.

via Nature.com|

#atlas #brain #cell-types

science-and-technology2 years ago•69 min saved

"Unveiling the Immune Response: Single-Cell Resolution Cytokine Dictionary"

Researchers have created a comprehensive dictionary of immune responses to cytokines at single-cell resolution. Using single-cell transcriptomic analysis, they profiled the responses of more than 17 immune cell types to 86 different cytokines in mouse lymph nodes. The study revealed cell-type-specific gene expression changes and identified distinct polarization states induced by cytokines in each cell type. The findings provide a molecular map of immune responses to cytokines and shed light on the complex interactions between cytokines and immune cells.

via Nature.com|

#cellular-polarization #cytokines #immune-responses

science2 years ago•3 min saved

Unraveling the Secrets of Limb Regrowth: The Axolotl's Groundbreaking Discovery

Researchers at EPFL and TU Dresden have discovered new insights into the limb regeneration abilities of axolotls, challenging previous assumptions. By creating an atlas of single-cell transcriptomes from multiple species, including humans and axolotls, the study revealed that axolotls have cells with characteristics similar to those essential for limb development in other species. However, the study also found that axolotls do not fully reform apical-ectodermal-ridge (AER) cells during limb regeneration, suggesting a unique approach to limb regrowth. These findings open up new possibilities for exploring limb regeneration strategies in mammals, including humans.

via Phys.org|

#axolotl #developmental-biology #limb-regeneration