Tag

Adverse Events

All articles tagged with #adverse events

healthcare1 month ago•3 min saved

Lilly’s triple-hormone obesity drug achieves major weight-loss results but unclear on heart risk

Eli Lilly’s retatrutide (GIP/GLP-1/glucagon triple agonist) met primary endpoints in two Phase 3 TRIUMPH trials, delivering about 21–23% weight loss at 80 weeks with the 12 mg dose vs ~3.2% for placebo (TRIUMPH-2: 20.8%; TRIUMPH-3: 22.6%). However, cardiovascular risk reduction was not clearly demonstrated, and GI side effects were common (diarrhea, nausea) with higher discontinuation rates. Lilly plans FDA submission in Q1 2027 and frames retatrutide as potentially applicable to obesity, knee osteoarthritis pain, and sleep apnea, though analysts warn the market could be niche and tolerability may limit use.

via Fierce Biotech|

#adverse-events #cardiovascular-risk #healthcare

healthcare2 months ago•2 min saved

Zynlonta safety concerns rise as LOTIS-5 shows higher deaths

ADC Therapeutics’ LOTIS-5 phase 3 trial in relapsed/refractory DLBCL shows Zynlonta plus Rituxan improving progression-free survival (6.1 vs 4.7 months) and complete response rate (39.5% vs 26.7%), but with more deaths (27/440, 13.2% vs 9/440, 4.6%) and higher serious adverse events, driven largely by older patients and potentially influenced by longer monitoring in the treatment arm. There was no detrimental effect on overall survival. The safety signal spurred a roughly 52% drop in the company’s stock; ADC says it will meet with the FDA in August and plans to submit for full approval in Q4, with Zynlonta remaining the company’s sole marketed product.

via Fierce Pharma|

#adverse-events #diffuse-large-b-cell-lymphoma #healthcare

health5 months ago•4 min saved

Study links Wegovy to higher risk of sudden vision loss vs Ozempic in GLP-1 drugs

A FDA adverse-event database analysis (2017–2024) suggests Wegovy users have about 4.7 times higher odds of ischemic optic neuropathy than Ozempic users, with no clear link for Rybelsus; findings are associations, not definitive risk estimates for all patients, and researchers call for prospective studies to guide prescribing and policy.

via ScienceAlert|

#adverse-events #glp-1 #health

health6 months ago•5 min saved

Paralysis Allegations Shake Nura Pain Clinic Over Spinal Stimulators

Three patients allege that spinal cord stimulator implants at Nura Pain Clinic caused paralysis or serious injuries, leading to lawsuits accusing doctors of risky placement and inadequate warnings; a third patient has joined the suits as the clinic says it emphasizes informed consent while litigation unfolds, and FDA data show thousands of adverse events linked to these devices, including cases of paralysis.

via kare11.com|

#adverse-events #health #lawsuit

diabetes8 months ago•2 min saved

FDA links multiple deaths and injuries to faulty Abbott glucose monitors

The FDA warns that some Abbott FreeStyle Libre 3 and 3 Plus glucose sensors may provide incorrect low readings due to a manufacturing issue, linked to hundreds of adverse events and seven deaths outside the U.S. Patients are advised to stop using affected devices and seek replacements, as the issue has been identified and resolved.

via CBS News|

#abbott #adverse-events #diabetes

health1 year ago•7 min saved

Second Death in Duchenne Gene Therapy Sparks Safety Concerns and Trial Halt

Following the death of a second patient treated with Elevidys for Duchenne muscular dystrophy, families and advocates are calling for greater transparency, improved safety data collection, and stronger regulatory oversight to ensure patient safety and informed decision-making in the use of this high-cost gene therapy.

via STAT|

#adverse-events #duchenne-muscular-dystrophy #elevidys

stock-market-news2 years ago•2 min saved

Verastem Stock Surges Over 50% on Positive Pancreatic Cancer Drug Data

Verastem (VSTM) stock plummeted by 62% following the release of clinical trial data for its metastatic pancreatic cancer treatment, which revealed serious adverse events in 12 patients, including 11 with grade ≥3 events. Despite initial positive results, the safety concerns led to heavy trading and a significant drop in stock value.

via InvestorPlace|

#adverse-events #clinical-trial #stock-drop

health2 years ago•5 min saved

The Lifelong Impact of Childhood Trauma on Health and Cognitive Function

A University of Michigan study has found that adverse childhood experiences can impact muscle function in older adults by impairing mitochondrial activity, leading to reduced ATP production. The research, which analyzed muscle biopsies from over 870 participants aged 70 and older, highlights the long-term health consequences of childhood trauma on physical health and emphasizes the importance of addressing childhood traumas to mitigate their lasting effects on aging outcomes.

via Neuroscience News|

#adverse-events #aging #childhood-trauma

health-medicine2 years ago•3 min saved

"New Study Reveals Covid-19 Vaccine Links to Health Conditions"

The largest global vaccine safety study to date found small increases in neurological, blood, and heart-related conditions linked to Covid-19 vaccines, including heart-related inflammation from mRNA shots and an increased risk of blood clots and neurological disorders from viral-vector vaccines. While over 13.5 billion doses of Covid vaccines have been administered globally, saving over 1 million lives in Europe alone, a small proportion of people immunized were injured by the shots, sparking debate about their benefits versus harms. Additionally, a separate study conducted by the Yale School of Medicine identified common symptoms in adults experiencing chronic post-vaccination syndrome, which aims to understand the condition and improve vaccine safety.

via South China Morning Post|

#adverse-events #covid-19 #global-vaccine-data-network

health2 years ago•4 min saved

"FDA Urges Immediate Action Against Dangerous Tianeptine Products"

The FDA is warning consumers against purchasing or using tianeptine products due to severe risks, including death, and lawmakers are calling for immediate action. Tianeptine, an antidepressant prescribed in other countries, is not approved for use in the US and is often sold illegally as a dietary supplement, posing serious health risks such as agitation, drowsiness, and even death. Lawmakers have urged the FDA to take action, and a company has voluntarily recalled its tianeptine products. The substance has been linked to numerous adverse events and deaths, and its availability in gas stations and convenience stores poses a significant risk, especially amid the ongoing opioid epidemic.

via CNN|

#adverse-events #antidepressant #fda

health2 years ago•6 min saved

The Growing Concerns of Ozempic's Mental Health Side Effects and Dangerous Alternatives

Reports of possible mental health side effects, including anxiety, depression, and suicidal thoughts, have been increasing among individuals taking Ozempic, an injectable drug approved for Type 2 diabetes. While the drug has gained popularity for its potential weight loss benefits, these mental health concerns are not mentioned in its instructions for use. European regulators are investigating the risk of self-harm and suicidal thoughts associated with Ozempic and similar drugs, while the FDA is monitoring the situation. The FDA's adverse event reporting system has received 489 reports of patients experiencing mental health issues while taking semaglutide drugs, including Ozempic. However, the database cannot determine whether these events are directly caused by the drug or other factors. Patients are advised to consult with their doctors if they experience any unusual symptoms.

via MPR News|

#adverse-events #fda #health

health3 years ago•4 min saved

COVID-19 Vaccine Showdown: Moderna Outperforms Pfizer-BioNTech for Seniors

A study conducted by researchers at Brown University compared the Moderna and Pfizer-BioNTech COVID-19 vaccines in over six million older adults and found that the Moderna vaccine was associated with slightly lower risks of certain adverse events, such as pulmonary embolism and thromboembolic events. The study highlights the importance of understanding real-world vaccine performance and recommends further research, including the evaluation of subsequent vaccinations and newly developed vaccines. While both vaccines were found to have low risks of adverse events, the findings suggest that the Moderna vaccine may have a slight edge over Pfizer-BioNTech for older adults.

via SciTechDaily|

#adverse-events #covid-19-vaccine #health

health3 years ago•4 min saved

Investigating Uncommon Connections: COVID Vaccines and Adverse Events

Researchers at Yale University are expanding their ongoing LISTEN study to include individuals experiencing adverse events after COVID-19 vaccination, in an effort to understand the rare symptoms that can occur post-vaccination. These symptoms, sometimes referred to as "long vax," resemble those seen in long COVID, including small-fiber neuropathy and postural orthostatic tachycardia syndrome (POTS). The study aims to match abnormal post-vaccine symptoms with corresponding immune responses and develop a better understanding of the mechanisms and potential therapeutic strategies for these conditions. The researchers also hope to provide support and validation to those experiencing post-vaccination symptoms and move the discussion away from politics and into science.

via Medpage Today|

#adverse-events #covid-19-vaccines #health

health3 years ago•4 min saved

Association Found Between Modest Decline in Kidney Function and Adverse Events

Modest reductions in kidney function, even within the normal range, are associated with a higher risk of adverse events, particularly among younger adults. A large cohort study found that slight decreases in estimated glomerular filtration rate (eGFR) were linked to a 42% increased risk of all-cause mortality, cardiovascular events, and kidney failure in adults under 40 years old. The findings highlight the importance of monitoring kidney function and adopting a healthy lifestyle to prevent future kidney and heart diseases. Once chronic kidney disease develops, it is rarely reversible, making early detection and prevention crucial.

via Medscape|

#adverse-events #cardiovascular-disease #chronic-kidney-disease

health3 years ago•0 min saved

"Understanding the Rotavirus: Symptoms, Treatment, and Prevention"

The article discusses the prevalence of the rotavirus vaccine despite its adverse events, including death. It explores why infants need to get vaccinated against rotavirus, which can cause severe diarrhea and dehydration. Parents are advised to consider the risks and benefits of the vaccine when deciding whether to give it to their child.

via The Daily Wire|

#adverse-events #childhood-diarrhea #health