Tag

Cancer Immunology

All articles tagged with #cancer immunology

health-and-medicine2 days ago•6 min saved

Dietary Yeast Trains Immune System to Fight Cancer in Mice

Researchers at Trinity College Dublin and University College Dublin found that a common dietary yeast beta-glucan supplement reprograms early bone marrow immune cells to create trained immunity that strengthens anti-tumor responses against colorectal, skin, and breast cancers in obese mice and can reverse obesity-related immune memory defects after weight loss; since Wellmune is already food-grade, this could accelerate human trials to test dietary supplementation alongside cancer therapies.

via Science Daily|

#bone-marrow #cancer-immunology #health-and-medicine

science2 months ago•13 min saved

When cancer hides MHC I, NK cells may strike back

For decades, MHC class I was seen as the marker used by T cells to detect cancer, but tumors that downregulate MHC I evade T cells while potentially exposing themselves to natural killer (NK) cells that detect 'missing self.' NK cells are inhibited by MHC I through receptors like KIRs, so loss of MHC I can lift that brake, creating a vulnerability. In practice, tumors face barriers to NK cell infiltration and can become exhausted, making responses inconsistent. Researchers are pursuing NK cell–based therapies and cytokine strategies to exploit MHC I loss, particularly in cancers resistant to checkpoint inhibitors, with the goal of turning this paradox into a new therapeutic avenue while continuing to tackle delivery and safety challenges.

via Space Daily|

#cancer-immunology #immunotherapy #mhc-i