Tag

Combination Therapy

All articles tagged with #combination therapy

health2 days ago•4 min saved

Wild tormentil uncovers plant compounds that fend off superbugs and boost antibiotics

A study screening bogland plants found tormentil (Potentilla erecta) extracts to be antimicrobial, to limit biofilm formation, and to enhance the effectiveness of the last-resort antibiotic colistin when used together, via compounds like ellagic acid and agrimoniin that appear to work by iron chelation; this highlights plant compounds as sources of new antimicrobials and antibiotic adjuvants amid rising antimicrobial resistance.

via The Conversation|

#antimicrobial-resistance #biofilms #combination-therapy

science28 days ago•8 min saved

Triple-Drug KRAS Attack Erases Pancreatic Tumors in Mice

CNIO researchers report a triple-drug regimen that blocks the KRAS signaling pathway at three points—using daraxonrasib, afatinib, and SD36—to induce durable tumor regression and prevent resistance in three mouse models of pancreatic ductal adenocarcinoma (PDAC) with minimal toxicity. While promising, they caution that the approach is not yet ready for clinical trials and would require further development to adapt for human use, per the PNAS study.

via SciTechDaily|

#cnio #combination-therapy #drug-resistance

science2 months ago•5 min saved

THC plus celecoxib boosts Alzheimer's therapy potential in mice

In mouse models of Alzheimer's, a low-dose THC combined with the anti-inflammatory drug celecoxib improved learning, reduced beta-amyloid and tau pathology, and lowered neuroinflammation, suggesting a feasible path to clinical testing since both drugs are already FDA-approved.

via SciTechDaily|

#alzheimers-disease #celecoxib #combination-therapy

business2 months ago•10 min saved

Obesity drug era expands with pills, combos and broader access

At the JPMorgan Healthcare Conference, executives from Lilly, Novo Nordisk, Pfizer and others said the obesity-drug market will broaden beyond injections to a menu of options—oral GLP-1 pills, combination regimens, and treatments aimed at preserving muscle—while prices fall, Medicare coverage rolls out, and direct-to-consumer channels grow, potentially pushing the market toward $100 billion annually by 2030 as new entrants and tailored therapies expand patient access and choices.

via CNBC|

#access #business #combination-therapy

health5 months ago•4 min saved

Combination Therapy Boosts Survival Rates in Aggressive Prostate Cancer by 40%

A landmark study published in NEJM shows that pairing Leuprolide and Enzalutamide significantly increases survival rates for men with high-risk, recurring prostate cancer, emphasizing early detection, proactive treatment, and lifestyle management to improve quality of life.

via Times of India|

#combination-therapy #health #landmark-study

health10 months ago•1 min saved

New Drug Combo Significantly Reduces Breast Cancer Progression Risk

A Phase 3 study shows that combining Gilead's Trodelvy with Merck's Keytruda significantly reduces tumor progression risk in women with aggressive triple-negative breast cancer, potentially leading to new treatment options.

via statnews.com|

#breast-cancer #clinical-trial #combination-therapy

health10 months ago•3 min saved

Pfizer's Braftovi Significantly Extends Survival in Advanced Colorectal Cancer

A late-stage trial found that a Pfizer combination therapy, including chemotherapy, cetuximab, and Braftovi, doubled survival time for patients with aggressive colorectal cancer with BRAF V600E mutation, setting a new standard of care for this subset of patients.

via NBC News|

#braf-mutation #colon-cancer #combination-therapy

health1 year ago•2 min saved

Effective Hypertension Treatments for Underserved Populations

A global study conducted in India, known as the TOPSPIN trial, found that three different combination therapies for hypertension are equally effective in reducing blood pressure among South Asian populations. The study, which involved nearly 2000 participants, showed significant blood pressure reductions with all combinations, suggesting that physicians can choose treatments based on availability and cost. This research is particularly relevant for the large South Asian population in the US and highlights the potential for improved hypertension management in underserved groups.

via Medscape|

#blood-pressure-control #combination-therapy #global-health-study

health2 years ago•4 min saved

Risks of Unregulated Prescription Drug Combinations on the Rise

A study by the Center for Drug Safety and Effectiveness at Johns Hopkins University found that doctors are prescribing untested drug combinations with high addiction potential. The study examined patterns of medical amphetamine and methylphenidate stimulant drug use and found that many adults using Schedule II stimulants simultaneously use one or more additional CNS-active drugs, which can have tolerance and withdrawal effects or potential recreational abuse. The study reveals significant gaps in knowledge and oversight within the medical community, as the prescribing of multi-combination drug cocktails has yet to go through clinical trials.

via Medical Xpress|

#addiction #clinical-trials #cns-active-drugs

health3 years ago•12 min saved

Advancements in Alzheimer's Therapies: Current Trials and Future Prospects

Researchers are testing a range of potential new therapies for Alzheimer's disease, including combination therapies that target different stages of the disease, anti-tau and anti-amyloid vaccines, and gene therapy. Trials of combination therapies are complex and costly, but researchers hope that sensitive new biomarkers will help to uncover more about the mechanisms of Alzheimer's. Most researchers think that treatment will need to be personalized, and individuals at different disease stages will need different therapies.

via Nature.com|

#alzheimers #anti-amyloid-therapy #clinical-trials