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Antimicrobial Resistance

All articles tagged with #antimicrobial resistance

Lilly bets on prevention with three biotech acquisitions
business11 hours ago

Lilly bets on prevention with three biotech acquisitions

Lilly announced agreements to acquire Curevo, LimmaTech Biologics and Vaccine Company to broaden its infectious-disease portfolio with vaccine-based prevention for shingles, bacterial pathogens and EBV-related disease, respectively. The deals could total up to $3.83 billion in potential cash payments, contingent on milestones and regulatory clearances, and closing is subject to customary conditions, reflecting Lilly's strategy to prevent disease at the source and address antimicrobial resistance.

via PR Newswire|
#antimicrobial-resistance#business#infectious-disease
New Treponema A bacterium linked to noma could enable early tests and targeted treatment
health-global-health29 days ago

New Treponema A bacterium linked to noma could enable early tests and targeted treatment

Researchers studying noma patients in Nigeria identified a previously undescribed Treponema bacterium (Treponema A) in most samples, suggesting a possible causal or contributory role and raising the possibility of diagnostic tests at the gingivitis stage and targeted antibiotics to prevent progression. If confirmed, this could reduce mortality and lifelong disfigurement and lessen reliance on broad-spectrum antibiotics; a larger, multi-country study is planned to clarify Treponema A’s role.

via The Guardian|
#antimicrobial-resistance#early-detection#health-global-health
Global AMR wave: common infections resisting antibiotics worldwide
science1 month ago

Global AMR wave: common infections resisting antibiotics worldwide

A global review led by Jilin University and Peking Union Medical College Hospital finds antimicrobial resistance (AMR) is not a distant threat but a present crisis: common infections are increasingly no longer treatable with standard antibiotics, with regional patterns influenced by policy, practice, and environmental use; bacteria such as E. coli and Klebsiella show β-lactamase activity in parts of Asia while carbapenem resistance climbs in Europe and the Americas, and fungi like Candida auris also resist multiple drugs. Reversing the trend requires rapid diagnostics, precision dosing, smarter drug combinations, and robust national surveillance and stewardship, plus cutting agricultural antibiotic use and pursuing new antibiotics and antifungals within a One Health framework. The study appears in the Medical Journal of Peking Union Medical College Hospital.

via Earth.com|
#antibiotics#antimicrobial-resistance#one-health
Tiny Bog Wildflower Offers Hope Against Drug-Resistant Bacteria
science1 month ago

Tiny Bog Wildflower Offers Hope Against Drug-Resistant Bacteria

New research on bogland plants from Ireland finds tormentil extracts inhibit bacteria and biofilm formation, and can enhance the effectiveness of the last-resort antibiotic colistin; compounds like ellagic acid and agrimoniin may work by iron chelation, pointing to plant-derived antimicrobials as a potential aid against drug-resistant infections, with further formulation work underway.

via ScienceAlert|
#antibiotic-synergy#antimicrobial-resistance#biofilms
Wild tormentil uncovers plant compounds that fend off superbugs and boost antibiotics
health1 month ago

Wild tormentil uncovers plant compounds that fend off superbugs and boost antibiotics

A study screening bogland plants found tormentil (Potentilla erecta) extracts to be antimicrobial, to limit biofilm formation, and to enhance the effectiveness of the last-resort antibiotic colistin when used together, via compounds like ellagic acid and agrimoniin that appear to work by iron chelation; this highlights plant compounds as sources of new antimicrobials and antibiotic adjuvants amid rising antimicrobial resistance.

via The Conversation|
#antimicrobial-resistance#biofilms#combination-therapy
Microplastics fuel global spread of antibiotic‑resistant bacteria via biofilms
environment2 months ago

Microplastics fuel global spread of antibiotic‑resistant bacteria via biofilms

A Plymouth Marine Laboratory–Exeter study shows microplastics act as mobile surfaces for microbial communities, forming dense biofilms (the Plastisphere) that carry antibiotic‑resistance genes and potentially resistant pathogens. These plastics can transport microbes from hospital wastewater to rivers and oceans, with downstream and marine environments showing higher resistance gene levels, especially on polystyrene and nurdles. The findings highlight the need for closer monitoring of microplastics, reducing plastic pollution, and careful handling during beach cleanups to protect ecosystems and human health.

via Earth.com|
#antimicrobial-resistance#biofilms#environment
Dentists still prescribe millions of clindamycin despite life-threatening C. difficile risk
health3 months ago

Dentists still prescribe millions of clindamycin despite life-threatening C. difficile risk

Dentists prescribed over 2.3 million clindamycin prescriptions last year despite a decades‑old black‑box warning for serious C. difficile infections, even as overall dental antibiotic use rose about 6% from 2020 to 2025. The investigation ties unnecessary dental antibiotic prescribing to higher C. difficile risk and antimicrobial resistance, highlighting how private dental practice has lagged in antibiotic stewardship and guideline updates, with the story of Dolores Owens illustrating the potential harms of such prescribing.

via CIDRAP|
#antibiotic-stewardship#antimicrobial-resistance#c-difficile
Space Mutations Boost Phages in the Battle Against Superbugs
science3 months ago

Space Mutations Boost Phages in the Battle Against Superbugs

A UW–Madison-led study compared a E. coli–T7 phage clash on Earth and in microgravity aboard the ISS. In space, phages infect more slowly but still acquire mutations that improve their ability to bind bacterial receptors, while the bacteria develop space-specific defenses—demonstrating space-driven evolutionary paths that could inform phage-based strategies against drug‑resistant pathogens on Earth.

via Yahoo|
#antimicrobial-resistance#bacteriophage#evolution
health-and-science7 months ago

AI-Driven Discoveries in the Fight Against Superbugs

Dr. Fred Mutisya, a Kenyan medical doctor and AI innovator, developed antimicro.ai, an open-source AI tool to analyze data on antimicrobial resistance (AMR). His work aims to improve antibiotic use and combat AMR, which poses a significant global health threat. While successful in Europe, the tool has yet to be adopted widely in Kenya, highlighting challenges in local healthcare innovation adoption.

via Daily Nation|
#ai-innovation#antimicrobial-resistance#health-and-science