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Dam

All articles tagged with #dam

Aged white matter harbors a reversible senescent DAM microglia state linked to GAL3 signaling
science1 month ago

Aged white matter harbors a reversible senescent DAM microglia state linked to GAL3 signaling

In naturally aged mice, hippocampal-adjacent white matter accumulates a microglial population that co-expresses senescence and disease-associated microglia (DAM) markers, notably GAL3/Lgals3, defining a white matter–exclusive SenBrain-DAM state enriched in fimbria. Spatial profiling across IMC, GeoMx DSP and CosMx SMI reveals multiple age-related trajectories from homeostatic microglia to DAM and senescent states, with GAL3+ cells marking a prominent age-excluded subset. Systemic senotherapeutics targeting p16 (AP20187) or BCL2 (venetoclax) reduce GAL3+ DAM markers, lower p16, and restore microglial organization and morphology toward a youthful pattern in aged fimbria, including reduced APOE+ GAL3+ cell density and altered microglia–fiber tract alignment. These findings suggest a partially reversible senescence–DAM microglial phenotype in aging white matter and highlight GAL3/Lgals3 as a potential biomarker and target to mitigate white matter–related cognitive decline.

 unconventional geoengineering idea: could a Bering Strait dam avert AMOC collapse?
rivers-and-oceans4 months ago

unconventional geoengineering idea: could a Bering Strait dam avert AMOC collapse?

A new Science Advances study models building three dams across the 51-mile Bering Strait to see if closing the passage could strengthen the Atlantic Meridional Overturning Circulation (AMOC) and delay its collapse under warming. Results suggest that under lower CO2 and a mildly weakened AMOC, closure could help maintain AMOC, but with a much weaker AMOC it could accelerate decline; the plan would disrupt wildlife, Indigenous communities, fisheries, and shipping, and outcomes are highly uncertain, necessitating more modeling. Regardless, experts say reducing greenhouse gas emissions remains the most reliable way to protect AMOC.

Hawaii on high alert as worst flooding in two decades prompts mass evacuations
us5 months ago

Hawaii on high alert as worst flooding in two decades prompts mass evacuations

A Kona Low storm dumped extreme rainfall across Oahu and Maui, triggering a statewide flood watch and mass evacuations—more than 230 people rescued and thousands displaced—as authorities warn that saturated ground means even less rain could trigger dangerous floods; a dam near Honolulu is at risk of collapse, and damages could exceed $1 billion, marking Hawaii’s worst flood in 20 years.

Oahu Flood Crisis Triggers 5,500+ Evacuations as Dam Risks Elevate Hazard
weather5 months ago

Oahu Flood Crisis Triggers 5,500+ Evacuations as Dam Risks Elevate Hazard

Heavy rains on Oahu’s north shore have forced evacuations for about 5,500 residents, with Waialua residents urged to leave due to the risk of road failure. No deaths have been reported yet, but around 200 people have been rescued and 10 hospitalized for hypothermia. A 120-year-old Wahiawa dam is considered at imminent risk of failure, prompting further evacuations and a major mobilization of the Hawaii National Guard and other responders. Gov. Josh Green says damage could exceed $1 billion, and more rain is expected in coming days.

Kona-low floods Oahu as Wahiawa Dam danger triggers North Shore evacuations
weather5 months ago

Kona-low floods Oahu as Wahiawa Dam danger triggers North Shore evacuations

Oahu remains under a flash flood warning with a flash flood emergency on the North Shore as a Kona-low storm system dumps heavy rain statewide. Authorities say Wahiawa Dam is at imminent risk of failure, prompting evacuations downstream in Waialua and Haleiwa and the opening of multiple shelters. The Hawaii National Guard, Coast Guard, and Army personnel are assisting with rescues and evacuations, and power outages have affected thousands in evacuation zones. Forecasters warn more heavy rain is possible, and a statewide flood watch and additional advisories extend through the weekend, with Maui also under flood advisories and Hawaii Island facing a winter-storm watch for the peaks.

Oahu Evacuations Triggered as Wahiawa Dam Faces Potential Failure
us-news5 months ago

Oahu Evacuations Triggered as Wahiawa Dam Faces Potential Failure

Two powerful storms drenched Hawaii, pushing Wahiawa Dam on Oahu toward potential failure from overtopping and prompting evacuation orders for Waialua and Haleiwa, affecting about 4,000 residents. The 1906, 9,200-acre-foot earthen dam, owned by Dole and forming Lake Wilson, has a spillway that could be overwhelmed in a major flood. Officials say the risk is evolving, with flood watches in effect and more rain expected; Governor Josh Green urged residents to evacuate as state offices closed except emergency management.