All articles tagged with #ms
A preclinical study identifies CN045 as a lead small molecule that promotes maturation of oligodendrocyte progenitor cells (OPCs) into myelin-producing cells and modestly increases remyelination in a mouse model of MS, suggesting potential for a remyelination therapy but requiring optimization and later testing in people.
England’s NHS is rolling out fampridine, a twice-daily drug designed to improve walking in people with multiple sclerosis. It is the first MS treatment aimed at walking difficulties, with about 5,000 people expected to be eligible in the first year. Patients will try the drug for 2–4 weeks; those who show improvement can continue long-term. Trials show walking speed improves in around 43% of patients, helping mobility for those with EDSS scores from 4 to 7 and potentially enabling more independence. The MS Society welcomed the move and urged strong MS services to ensure broad access.
Christina Applegate’s friends fear the worst after her hospitalization amid long-running battles with multiple sclerosis, with insiders saying her days are often treacherous and she’s faced with both better and very bad spells; a representative offered no comment, and Applegate has publicly discussed her MS and recent health setbacks, including past kidney infection issues.
New research links exposure to 'forever chemicals' like PFOS and PCBs to an increased risk of developing multiple sclerosis, highlighting the long-term health risks of these persistent environmental toxins and the importance of reducing exposure.
Scientists discovered that losing a small, critical segment of myelin disrupts brain communication by impairing the transmission of signals between the cortex and thalamus, which can lead to cognitive issues similar to those seen in Multiple Sclerosis. The study highlights the importance of myelin in maintaining the structure of neural information transfer and suggests potential avenues for future recovery strategies.
A recent study reveals a strong geographic link between amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), suggesting shared environmental or social factors influence their distribution, challenging previous genetic-focused theories and opening new avenues for research and prevention.
A person with multiple sclerosis (MS) discusses the importance of getting vaccinated against flu, pneumococcal disease, and COVID-19 to protect themselves and others, highlighting their personal experience and the broader benefits of vaccination for vulnerable populations.
A study shows that Ocrevus rapidly depletes B-cells in MS patients and causes gradual changes in T-cells, including increased regulatory T-cells after six months, which may contribute to its long-term effectiveness.
Christina Applegate discusses how her MS diagnosis has deeply affected her 14-year-old daughter Sadie, describing it as a loss of the mother she once knew and highlighting the emotional toll on her family, while also sharing her recent hospitalization for a kidney infection.
A study from UBC suggests that early signs of multiple sclerosis (MS), such as mental health issues and general symptoms, may appear up to 15 years before diagnosis, indicating a longer prodromal phase and potential for earlier detection and intervention.
A study suggests that early signs of multiple sclerosis (MS), such as fatigue, headaches, dizziness, anxiety, and depression, can appear more than a decade before diagnosis, indicating a long prodromal phase and potential for earlier detection and intervention.
A mouse study suggests that herpes simplex virus type 1 (HSV-1) may contribute to multiple sclerosis (MS) by damaging myelin, with findings indicating that blocking the MLKL protein can prevent myelin loss and neurological damage, highlighting potential new treatment avenues.
Research suggests that UV light therapy may help treat autoimmune diseases like MS, Crohn's, and rheumatoid arthritis by reducing immune overreactions, with some patients experiencing significant symptom improvement after short daily sessions. While promising, larger studies are needed to confirm its effectiveness.
Ancient DNA analysis reveals that genetic variations associated with an increased risk of multiple sclerosis (MS) first emerged among herding populations in Eastern Europe thousands of years ago and spread across the continent. These genetic variants may have initially provided an advantage by turbocharging the immune system to fight off infections, but in modern times, they may lead to autoimmune diseases like MS. The findings shed light on the evolution of MS and other autoimmune diseases and have implications for understanding the causes and treatment of MS.
A study found that people with multiple sclerosis (MS) have high levels of T-cells in their spinal fluid that specifically target cells infected with the Epstein-Barr virus (EBV), suggesting a potential link between EBV and MS. The findings may help shed light on the processes that drive MS, as infection with EBV has been identified as one of the strongest risk factors for developing MS. The study's data suggest that these T-cells may be either causing the disease or contributing to it, and further research is ongoing to better understand the biological activity of these EBV-specific T-cells.